Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T8873 |
Bractoppin
|
Others; DNA/RNA Synthesis | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Others |
Bractoppin 是一种BRCA1 (t)BRCT domain 识别磷酸肽的选择性抑制剂,IC50为 74 nM。它优先抑制 BRCA1 -tBRCT 依赖的 DNA 损伤。它减少 BRCA1 对 DNA 断裂片段的招募,进而抑制损伤诱导的 G2 期阻滞和重组酶 RAD51 的组装。 | |||
T8637 |
DMNB
6-Nitroveratraldehyde,6-硝基藜芦醛 |
DNA-PK | DNA Damage/DNA Repair; PI3K/Akt/mTOR signaling |
DMNB (6-Nitroveratraldehyde) 可用于合成no-carrier-added 6-[18F]fluoro-L-DOPA (6-FDOPA)。它可用于研究多巴胺能系统的PET。 | |||
T9760 |
IC 86621
|
DNA-PK | DNA Damage/DNA Repair; PI3K/Akt/mTOR signaling |
IC 86621 是一种选择性和可逆的 ATP 竞争性 DNA-PK 抑制剂,IC50 为 120 nM。 IC 86621 增加 DNA 双链断裂 (DSB) 诱导的抗肿瘤活性,其 EC50 为 68 µM,用于 DNA-PK 介导的细胞 DSB 修复。 | |||
T11600 |
IBR2
Isoquinoline |
DNA/RNA Synthesis | Cell Cycle/Checkpoint; DNA Damage/DNA Repair |
IBR2(Isoquinoline)是一种针对RAD51的强效特异性抑制剂,通过干预RAD51多聚体形成,加速蛋白酶体介导的RAD51蛋白降解,抑制癌细胞生长并诱导凋亡。实验证明在抑制RAD51介导的DNA双链断裂修复方面有效。 | |||
T50098 |
TIQ-A
|
PARP | Chromatin/Epigenetic; DNA Damage/DNA Repair |
TIQ-A 是一种 PARP1 抑制剂,通过碱基切除修复途径参与 DNA 单链断裂修复。 PARP1 由 DNA 损伤触发,其过度激活已被认为是许多病理状况的致病因素,包括缺血和再灌注损伤、哮喘相关炎症和动脉粥样硬化形成。 | |||
T11067 |
VX-984
M9831 |
DNA-PK | DNA Damage/DNA Repair; PI3K/Akt/mTOR signaling |
VX-984 (M9831) 是一种可口服的、具有选择性的的、可透过血脑屏障的 DNA-PK 抑制剂。VX-984 对非同源性末端 NHEJ 的接合具有抑制作用,可作用于 DSBs 使 DNA 双链断裂。VX-984常见于对胶质母细胞瘤 (GBM) 和非小细胞肺癌 (NSC-LC) 的研究。 | |||
T20907 |
DBC
3,4,5,6-Dibenzocarbazole |
||
DBC, a ubiquitous environmental pollutant, induces significant DNA strand break levels and micronuclei in HepG2 cells. | |||
T68895 |
CBP-93872
|
||
CBP-93872 is a G2 checkpoint inhibitor. CBP-93872 specifically abrogates the DNA double-stranded break (DSB)-induced G2 checkpoint through inhibiting maintenance. CBP-93872 is an inhibitor of maintenance of the DSB-specific G2 checkpoint and thus might be a strong candidate as the basis for a drug that specifically sensitizes p53-mutated cancer cells to DSB-inducing DNA damage therapy. | |||
T60621 |
PFM03
|
||
PFM03 是MRE11 核酸内切酶抑制剂,可通过非同源末端连接 (NHEJ) 调节 DNA 双链断裂修复 (DSBR) [1]。 | |||
T68870 |
SU-11752
|
||
SU-11752 is a potent and selective DNA-PK inhibitor. Inhibition kinetics and a direct assay for ATP binding showed that SU11752 inhibited DNA-PK by competing with ATP. SU11752 inhibited DNA double-strand break repair in cells and gave rise to a five-fold sensitization to ionizing radiation. At concentrations of SU11752 that inhibited DNA repair, cell cycle progression was still normal and ATM kinase activity was not inhibited. | |||
T79330 |
PARP-1-IN-13
|
PARP | Chromatin/Epigenetic; DNA Damage/DNA Repair |
PARP-1-IN-13 (Compound 19c) 为一种高效PARP-1抑制剂,其IC50值为26 nM。该化合物能够抑制DNA单链断裂修复并增强DNA双链断裂效应。此外,PARP-1-IN-13通过激活线粒体凋亡(apoptosis)途径来促进癌细胞死亡。 | |||
T60649 | AV-153 free base | ||
AV-153 free base 是一种 1,4-二氢吡啶(1,4-DHP) 衍生物。AV-153 free base 是一种抗诱变剂,具有抗癌活性。AV-153 free base 可以与胞嘧啶和胸腺嘧啶相互作用,并影响聚 (ADP) 核糖基化。在体外实验中,AV-153 free base 在 DNA 的单链断裂处插入到 DNA 并减少 DNA 损伤,刺激 DNA 修复。 |