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Search Results for " dgk "

18

抑制剂 & 化合物

1

天然产物

3

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T39982	DGK-IN-1
	DGK-IN-1, an extracted T cell activator, holds potential in leveraging tumor immunity.
T22726	Dioctanoylglycol 2-octanoyloxyethyl octanoate,Dioctanoyl ethylene glycol,Ethylene glycol dioctanoate,ethane-1,2-diyl dioctanoate	Others	Others
	Dioctanoylglycol (ethane-1,2-diyl dioctanoate) 是二酰基甘油类似物，也是二酰基甘油激酶 (DGK) 抑制剂，其Ki=为58 μM。
T79825	DGKζ-IN-4
	DGKζ-IN-4是一种inhibitor，可作为药物配方中的active ingredient。该化合物适用于治疗与immune cell activation相关联的cancer types或对抗PD-1 antibody/PD-L1 antibody治疗产生resistance的cancer。
T79822	DGKα-IN-3
	DGKα-IN-3 作为DGKα抑制剂，具有283 nM的IC50。该化合物能够通过提升T细胞的增殖及功能，显著增强抗PD-1治疗的抗肿瘤效果。因此，DGKα-IN-2在肿瘤和免疫学领域研究中显示出了潜在的应用价值。
T82573	DGKζ-IN-3
	DGKζ-IN-3为一种针对DGKζ (二酰基甘油激酶 zeta)的抑制剂，适用于治疗由DGKζ调节异常引起的液体和固体癌症。
T79824	DGKα&ζ-IN-1
	DGKα&ζ-IN-1 (Compound II) 为DGK抑制剂，具有增强T细胞功能并与PD-1联用时显示协同效果，用于免疫及肿瘤治疗。
T79828	DGKα-IN-8
	DGKα-IN-8（Example 51）是DGKα的高效抑制剂，其IC50值为22.491 nM，EC50值为0.256 nM。该化合物主要用于癌症（含实体瘤）及HIV和乙型肝炎病毒感染的研究领域。
T79136	DGKζ-IN-1
	DGKζ-IN-1（化合物9）是一种DGKζ的抑制剂，用于研究与免疫细胞激活相关的癌症或对抗PD-1抗体/抗PD-L1抗体耐药的癌症。
T79821	DGKα-IN-2
	DGKα-IN-2（例48）是一种具有IC50为0.9 nM的DGKα抑制剂。该化合物能显著增强T细胞增殖与功能，从而提升抗PD-1治疗的抗肿瘤效果，对肿瘤与免疫学领域的研究具有潜在价值。
T79823	DGKα-IN-4
	DGKα-IN-4 (example 432) 为一种DGKα抑制剂，IC50值达0.1 nM。该抑制剂能够提升T细胞的增殖与功能，从而显著增强抗PD-1治疗的抗肿瘤效果。DGKα-IN-2在肿瘤与免疫学领域研究中显示出其潜在应用价值。
T79826	DGKα-IN-6
	DGKα-IN-6，一种DGKα抑制剂，其IC50值为1.377 nM，显示出可能用于癌症研究。
T79827	DGKα-IN-7
	DGKα-IN-7, 一种IC50为6.225 nM的DGKα抑制剂，该化合物具有潜在的癌症研究应用。
T38209	Hodgkinsine
	Hodgkinsine is a pyrrolidinoindoline alkaloid that has been found inP. colorataand has analgesic activity.1It increases latency to paw licking in the hot plate test and latency to tail withdrawal in the tail-flick test in mice when administered at a dose of 5 mg/kg. 1.Amador, T.A., Verotta, L., Nunes, D.S., et al.Antinociceptive profile of hodgkinsinePlanta Med.66(8)770-772(2000)
T38210	Hodgkinsine B
	Hodgkinsine B is an alkaloid and isomer of hodgkinsine that has analgesic activity.1It increases the latency to tail withdrawal in the tail-flick test in mice when administered at a dose of 10 mg/kg. 1.Kodanko, J.J., Hiebert, S., Peterson, E.A., et al.Synthesis of all low-energy stereoisomers of the tris(pyrrolidinoindoline) alkaloid hodgkinsine and preliminary assessment of their antinociceptive activityJ. Org. Chem.72(21)7909-7914(2007)
T77761	BMS-502	Others	Others
	BMS-502 是一种二酰基甘油激酶 (DGK) α 和 ζ 的强效双重抑制剂，诱导人和小鼠T细胞的免疫反应，阻断 T 细胞中细胞内检查点信号传导。BMS-502 以剂量依赖的方式刺激免疫反应，可用于研究与免疫相关的疾病。
T72322	R 59-022 hydrochloride DKGI-I hydrochloride,Diacylglycerol kinase inhibitor I hydrochloride,DKGI-I hydrochloride ; Diacylglycerol kinase inhibitor I hydrochloride	5-HT Receptor; PKC	Chromatin/Epigenetic; Cytoskeletal Signaling; GPCR/G Protein; Neuroscience
	R 59-022 hydrochloride (DKGI-I hydrochloride) 是一种 5-HT Receptor 拮抗剂，可激活蛋白激酶 C (PKC)。R 59-022 hydrochloride 是一种 DGK 抑制剂 (IC50:2.8 µM),可抑制 OAG 磷酸化为 OAPA。R 59-022 增强血小板中凝血酶诱导的甘油二酯的产生，并抑制嗜中性粒细胞中磷脂酸的产生。
T26019	R59949 R-59949,R 59949	Others; PKC	Chromatin/Epigenetic; Cytoskeletal Signaling; Others
	R59949 是一种泛二酰甘油激酶(DGK)抑制剂，IC50为 300 nM。它通过提高内源性配体二酰甘油水平来激活蛋白激酶 C(PKC)。它强烈抑制 Ⅰ 型 DGKα 和 γ 的活性，中度减弱 Ⅱ 型 DGKθ 和 κ 的活性。
T16709	R 59-022 Diacylglycerol kinase inhibitor I,DKGI-I	Others	Others
	R 59-022 is a 5-HTR antagonist and activates protein kinase C (PKC). R 59-022 is a diacylglycerol kinase inhibitor (IC50=2.8 μM). R 59-022 potentiates thrombin-induced diacylglycerol production in platelets and inhibits phosphatidic acid production in neu

化合物

Cat.No: T39982

Dioctanoylglycol

Cat.No: T22726

Synonym: 2-octanoyloxyethyl octanoate,Dioctanoyl ethylene glycol,Ethylene glycol dioctanoate,ethane-1,2-diyl dioctanoate

Target: Others

Cat.No: T79825

Cat.No: T79822

Cat.No: T82573

DGKα&ζ-IN-1

Cat.No: T79824

Cat.No: T79828

Cat.No: T79136

Cat.No: T79821

Cat.No: T79823

Cat.No: T79826

Cat.No: T79827

Cat.No: T38209

Cat.No: T38210

Cat.No: T77761

Target: Others

R 59-022 hydrochloride

Cat.No: T72322

Synonym: DKGI-I hydrochloride,Diacylglycerol kinase inhibitor I hydrochloride,DKGI-I hydrochloride ; Diacylglycerol kinase inhibitor I hydrochloride

Target: 5-HT Receptor, PKC

Cat.No: T26019

Synonym: R-59949,R 59949

Target: Others, PKC

Cat.No: T16709

Synonym: Diacylglycerol kinase inhibitor I,DKGI-I

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T69446	Cochlioquinone A
	Cochlioquinone A is an inhibitor of diacylglycerol kinase (DGK) and diacylglycerol acyltransferase (DGAT). It has been shown to reduce the concentration of phosphatidic acid in T cell lymphoma and has also been shown to compete with macrophage inflammatory protein-1α for binding to human CCR5 chemokine receptors.

天然产物

Cochlioquinone A

Cat.No: T69446

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPH-01211	DGUOK Protein, Human, Recombinant (His & SUMO) Deoxyguanosine kinase, mitochondrial,Deoxyadenosine kinase, ...	Human	E. coli
	Phosphorylates deoxyguanosine and deoxyadenosine in the mitochondrial matrix, with the highest efficiency for deoxyguanosine. In non-replicating cells, where cytosolic dNTP synthesis is down-regulated, mtDNA synthesis depends solely on DGUOK and TK2. Phosphorylates certain nucleoside analogs. Widely used as target of antiviral and chemotherapeutic agents.
TMPH-01222	DGKA Protein, Human, Recombinant (His) Diacylglycerol kinase alpha,80 kDa diacylglycerol kinase,DAG...	Human	E. coli
	Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids. Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes. Also plays an important role in the biosynthesis of complex lipids (Probable). Can also phosphorylate 1-alkyl-2-acylglycerol in vitro as efficiently ...
TMPJ-00922	DCK Protein, Human, Recombinant (His & T7) DCK,Deoxycytidine Kinase	Human	E. coli
	Deoxycytidine Kinase (DCK) is a member of the DCK/DGK family. DCK exists as a homodimer and is localized to the nucleus. DCK is required for the phosphorylation of the deoxyribonucleosides deoxycytidine (dC), deoxyguanosine (dG), and deoxyadenosine (dA). DCK has broad substrate specificity, and does not display selectivity based on the chirality of the substrate. In addition, DCK is also an essential enzyme for the phosphorylation of numerous nucleoside analogs widely employed as antiviral and c...

重组蛋白

DGUOK Protein, Human, Recombinant (His & SUMO)

Cat.No: TMPH-01211

Species: Human

Expression System: E. coli

DGKA Protein, Human, Recombinant (His)

Cat.No: TMPH-01222

Species: Human

Expression System: E. coli

DCK Protein, Human, Recombinant (His & T7)

Cat.No: TMPJ-00922

Species: Human

Expression System: E. coli

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