Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T13349 |
WS-383
|
E1/E2/E3 Enzyme | Ubiquitination |
WS-383 是高效、选择性、可逆的DCN1-UBC12相互作用抑制剂,IC50为11 nM。它抑制 Cul3/1 的类泛素化修饰,引起 NRF2,p21和p27 的积累。 | |||
T63647 |
DCN1-UBC12-IN-1
|
||
DCN1-UBC12-IN-1 是有效的、特异性的 DCN1-UBC12 抑制剂,其 IC50 值为 2.86 nM,具有抗心脏成纤维化活性。 | |||
T63820 |
DCN1-UBC12-IN-2
|
||
DCN1-UBC12-IN-2 是有效的、特异性的 DCN1-UBC12 抑制剂,其 IC50 值为 9.55 nM。DCN1-UBC12-IN-2 能够特异性靶向 DCN1-UBC12 相互作用,减缓 Ang II 诱导的心脏成纤维细胞活化。 | |||
T9140 |
NAcM-OPT HCl(2089293-61-6 free base)
|
NEDD8 | Metabolism |
NAcM-OPT HCl(2089293-61-6 free base) 是一种可口服的 cullin neddylation 1 (DCN1) 抑制剂,靶向 N-Acetyl-UBE2M(E2 结合酶,UBC12)与 DCN1 的相互作用,IC50 为 79 nM。 | |||
T13348 |
WS-383 free base
|
Others | Others |
WS-383 free base is a selective and reversible DCN1-UBC12 interaction inhibitor(IC50 of 11 nM). | |||
T11033 |
DI-591
|
Others | Others |
DI-591 is an effective, high-affinity and cell-permeability inhibitor for DCN1-UBC12 interaction. DI-591 binds to DCN1 and DCN2 with Ki values of 12 and nM and 10.4 nM, respectively, and has no obvious binding to DCN3, DCN4 and DCN5 proteins. | |||
T23989 |
DI-404
|
||
DI-404 is a high-Affinity Peptidomimetic the DCN1-UBC12 Protein-Protein Interaction inhibitor (Kd= 6.9 nM). DI-404 effectively and selectively inhibits the neddylation of cullin 3 over other cullin members. |