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Search Results for " cytochalasin a "

4

抑制剂 & 化合物

12

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T36005	1-Oleoyl-2-Palmitoyl-rac-glycerol
	1-Oleoyl-2-palmitoyl-rac-glycerol (1,2-OP) is a diacylglycerol containing oleic acid at the sn-1 position and palmitic acid at the sn-2 position. It enhances the inhibition of superoxide anion production by cytochalasin B when used at a concentration of 10 μM. The concentration of 1,2-OP decreases from 25.7 to 11.15% during the dry-curing process of Iberian ham.
T37477	L-858,051 (hydrochloride)
	L-858,051 is a water-soluble analog of forskolin , a cell-permeant activator of adenylate cyclase. L-858,051 activates adenylate cyclase (EC50 = 3 μM), inhibits glucose transport, and blocks cytochalasin B binding in rat adipocyte membranes. L-858,051 is used to activate adenylate cyclase and initiate signaling through elevated cAMP synthesis in a variety of cell types in culture.
T11042	Dihydrocytochalasin B	Others	Others
	Dihydrocytochalasin B (H2CB) is a cell division inhibitor that changes the morphology of cells, similar to cytochalasin B. Does not inhibit glucose transport. Dihydrocytochalasin B (H2CB) disrupts the structure of actin and inhibits the ability of growth
T36355	Sydowinin B
	Sydowinin B is a xanthone polyketide that has been found inA. sydowiiand has immunosuppressant activity.1It inhibits LPS- or concanavalin A-induced proliferation of isolated mouse splenic lymphocytes (IC50s = 19.2 and 20.8 μg/ml, respectively).2Sydowinin B inhibits superoxide generation in, and elastase release from, isolated human neutrophils induced by cytochalasin B and N-Formyl-Met-Leu-Phe with IC50values of 21.2 and 12.62 μM, respectively.3

化合物

1-Oleoyl-2-Palmitoyl-rac-glycerol

Cat.No: T36005

L-858,051 (hydrochloride)

Cat.No: T37477

Dihydrocytochalasin B

Cat.No: T11042

Target: Others

Cat.No: T36355

Cat. No.	Product Name	Target	Signaling Pathways
T10928	Cytochalasin A	HIV Protease	Microbiology/Virology; Proteases/Proteasome
	Cytochalasin A is a cell-permeable fungal toxin and is an oxidized derivative of cytochalasin B. Cytochalasin A is an inhibitor of HIV-1 protease (IC50 = 3 μM), inhibits actin polymerization and interferes with microtubule assembly by reacting with sulfhy
T82628	Cytochalasin N
	Cytochalasin N，一种细胞松弛素，源自内生真菌Phomopsis sp. CIB-109。
T79988	Cytochalasin R
	Cytochalasin R (compound 17)是从内生真菌拟茎点霉菌sp. xz-18中提取的一种Cytochalasin类似物，表现出潜在的抗真菌活性。
T82629	Cytochalasin K
	Cytochalasin K (化合物7) 是一种IC50为22.58 μM的细胞松弛素，能抑制小麦根系伸长。
T82627	Cytochalasin O
	Cytochalasin O (compound 13)，为P. sp. CIB-109植物病原真菌的次级代谢产物。
T7097	Cytochalasin B Phomin,细胞松弛素 B,细胞松弛素B	Arp2/3 Complex	Cytoskeletal Signaling
	Cytochalasin B is a mycotoxin binding to the barbed end of actin filaments. It can disrupt the formation of actin polymers (Kd: 1.4-2.2 nM for F-actin).
T21513	Cytochalasin H (16-Benzyl-5,12-dihydroxy-5,7,14-trimethyl-13-methylidene-18-oxo-17-azatricyclo[9.7.0.01,15]octadeca-3,9-dien-2-yl) acetate,细胞松驰素 H	MMP	Proteases/Proteasome
	Cytochalasin H ((16-Benzyl-5,12-dihydroxy-5,7,14-trimethyl-13-methylidene-18-oxo-17-azatricyclo[9.7.0.01,15]octadeca-3,9-dien-2-yl) acetate) 是肌动蛋白掺入细丝的有效抑制剂。
T13630	Cytochalasin C	Others	Others
	Cytochalasin C is a cell-permeable fungal toxin that can induce the formation of nuclear sticks. Cytochalasin C is 10 times less toxic than cytochalasin D in mice.
T15039	Cytochalasin E	Others	Others
	Cytochalasin E is a potent actin depolymerization agent and an epoxide containing Aspergillus-derived fungal metabolite. Cytochalasin E also inhibits angiogenesis and tumor growth. It binds and caps the barbed end of actin filaments to prevent actin elong
TN2408	Evofolin B	Cannabinoid Receptor	GPCR/G Protein
	Evofolin B 是从Zanthoxylum ailanthoides 的茎皮中分离出来的天然化合物。Evofolin B 对人类中性粒细胞对甲酰-L-蛋氨酸-L-亮氨酸-L-苯丙氨酸/cytochalasin B（fMLP/CB）产生的超氧阴离子有抑制作用。
TN2767	2'-Hydroxygenistein 鲁冰花	Antifection	Microbiology/Virology
	2'-Hydroxygenistein has antifungal activity, dimerization of it causes a remarkable increase of antifungal activity. It shows significant concentration-dependent inhibitory effects on the release of beta-glucuronidase and lysozyme from rat neutrophils in response to formyl-Met-Leu-Phe/cytochalasin B. 2'-Hydroxygenistein of genistein can enhance its antioxidant activity and cell cytotoxicity in MCF-7 human breast cancer cells.
TN2766	2'-Hydroxydaidzein	Cannabinoid Receptor; Antioxidant	GPCR/G Protein; oxidation-reduction
	2'-Hydroxydaidzein 是一种在植物中发现的异黄酮类植物素，是一种天然化合物。2'-Hydroxydaidzein 具有抗氧化活性，主要由o -氢键解离焓(BDE)和氢原子转移(HAT)机制驱动。2'-Hydroxydaidzein 抑制炎症细胞中的化学介质，可能对治疗和预防与化学介质产生过多有关的中枢和外周炎症性疾病有作用。2'-Hydroxydaidzein 对大鼠中性粒细胞和formyl-Met-Leu-Phe/cytochalasin B（fMLP/CB）的释放具有抑制作用，IC（50）值分别为2.8+/-0.1和5.9+/-1.4 microM。

天然产物

Cytochalasin A

Cat.No: T10928

Target: HIV Protease

Cytochalasin N

Cat.No: T82628

Cytochalasin R

Cat.No: T79988

Cytochalasin K

Cat.No: T82629

Cytochalasin O

Cat.No: T82627

Cytochalasin B

Cat.No: T7097

Synonym: Phomin,细胞松弛素 B,细胞松弛素B

Target: Arp2/3 Complex

Cytochalasin H

Cat.No: T21513

Synonym: (16-Benzyl-5,12-dihydroxy-5,7,14-trimethyl-13-methylidene-18-oxo-17-azatricyclo[9.7.0.01,15]octadeca-3,9-dien-2-yl) acetate,细胞松驰素 H

Target: MMP

Cytochalasin C

Cat.No: T13630

Target: Others

Cytochalasin E

Cat.No: T15039

Target: Others

Cat.No: TN2408

Target: Cannabinoid Receptor

2'-Hydroxygenistein

Cat.No: TN2767

Synonym: 鲁冰花

Target: Antifection

2'-Hydroxydaidzein

Cat.No: TN2766

Target: Cannabinoid Receptor, Antioxidant

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