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抑制剂 & 化合物

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T64779	Cypate
	3-(2-(7-(3-(2-Carboxyethyl)-1,1-dimethyl-1H-benzo[e]indol-3-ium-2-yl)hepta-2,4,6-trien-1-ylidene)-1,1-dimethyl-1,2-dihydro-3H-benzo[e]indol-3-yl)propanoate 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T64779。
T64220	Cyclophilin inhibitor 3
	Cyclophilin inhibitor 3 (compound 7c) 是一种 cyclophilin A (CypA) 的有效抑制剂，表现出有效的抗 HCV 作用，其 EC50 值为 4.2 μM。
T79870	RMC-4998	Ras	GPCR/G Protein; MAPK
	RMC-4998是一种分子胶化合物，显示出显著的抗肿瘤活性。该化合物能够与CYPA形成三元复合体，进而与KRAS G12C的激活状态突变体相结合。RMC-4998与CYPA结合后，可阻碍激活的KRAS G12C突变体与其下游效应蛋白的交互作用，有效抑制了促细胞增殖的信号传导。
T36642	RAS/RAS-RAF-IN-1
	RAS/RAS-RAF-IN-1 is a potent RAS and RAS-RAF inhibitor. RAS/RAS-RAF-IN-1 has a KD of 5.0 μμ-15 μμ for cyclophilin A (CYPA) binding affinity. RAS/RAS-RAF-IN-1 has antitumor activity[1]. RAS/RAS-RAF-IN-1 (compound 89; for 4 hours) has an EC50 of 0.5 μμ-5.0 μμ for BRAF-GTP-KRAS-G12C disruption and has an IC50 of 1.0 μμ-10 μμ for pERK inhibition in H358 cells[1]. [1]. Meizhong Jin, et al. Compounds that participate in cooperative binding and uses thereof. WO2020132597A1.
T75131	RMC-6291
	RMC-6291 是一种口服有效的KRASG12C(ON)共价抑制剂。RMC-6291 在 KRASG12C(ON) 和亲环蛋白 A (CypA) 之间的肿瘤细胞内形成三复合物。因此，RMC-6291 通过空间阻断RAS 效应子结合来阻止 KRASG12C(ON) 发出信号。RMC-6291 在 KRASG12C 肿瘤模型中对RAS 通路活性产生了深度和持久抑制。
T10919	Cyclophilin inhibitor 1	Others	Others
	Cyclophilin inhibitor 1 is an effective and orally bioavailable cyclophilin A inhibitor with a Kd of 5 nM, showing potent anti-HCV activity, and an EC50 for HCV 2a of 98 nM.

化合物

Cyclophilin inhibitor 3

Cyclophilin inhibitor 1

Cat.No: T10919

Synonym:

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPJ-00048	CYPA Protein, Mouse, Recombinant SP18,PPIA,PPIase A,Peptidyl-prolyl cis-trans isomerase A,	Mouse	E. coli
	Peptidyl-prolyl cis-trans isomerase A is a cytoplasm protein which belongs to the cyclophilin-type PPIase family and PPIase A subfamily. Cyclophilins(CyPs) are a family of proteins found in organisms ranging from prokaryotes to humans. These molecules exhibit peptidyl-prolyl isomerase activity, suggesting that they influence the conformation of proteins in cells. Cyclophilin A accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopep...
TMPJ-01049	CYPA Protein, Human, Recombinant Rotamase A,Peptidyl-prolyl cis-trans isomerase A,PPIase A,PP...	Human	E. coli
	Peptidyl-prolyl cis-trans isomerase A is a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family, which catalyzes the cis-trans isomerization of proline imidic peptide bonds. Cyclophilin A regulate many biological processes, including intracellular signaling, transcription, inflammation, and apoptosis. Cyclophilin is also incorporated into many viruses, including HIV1, where it has been speculated to be involved in functions such as viral assembly and infectivity. The immunosuppressi...
TMPY-01593	Cyclophilin A Protein, Mouse, Recombinant (His) peptidylprolyl isomerase A (cyclophilin A),Cphn,CyP-18,27000...	Mouse	E. coli
	Cyclophilin A Protein, Mouse, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 18.8 kDa and the accession number is P17742.
TMPY-02177	Cyclophilin A Protein, Human, Recombinant (His) CYPA,peptidylprolyl isomerase A (cyclophilin A),HEL...	Human	E. coli
	Cyclophilin A Protein, Human, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 19.4 kDa and the accession number is P62937.
TMPH-00364	Pectate lyase 1 Protein, Chamaecyparis obtusa, Recombinant (His & SUMO)	Chamaecyparis obtusa	E. coli
	Has pectate lyase activity. Pectate lyase 1 Protein, Chamaecyparis obtusa, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 54.1 kDa and the accession number is Q96385.
TMPH-00817	Pectate lyase 1 Protein, Hesperocyparis arizonica, Recombinant (His & Myc)	Hesperocyparis arizonica	E. coli
	Has pectate lyase activity. Pectate lyase 1 Protein, Hesperocyparis arizonica, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 42.6 kDa and the accession number is Q9SCG9.