4
2
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T117521 |
7-BFC
7-Benzyloxy-4-(trifluoromethyl)coumarin,Y040-0031 |
P450 | Metabolism |
7-BFC (7-Benzyloxy-4-(trifluoromethyl)coumarin) 是一种香豆素类荧光底物,可作为细胞色素 P 450 的生物标记物,可用于研究 CYP 亚型和细胞色素 P 450 代谢。 | |||
T35716 |
N-desmethyl Olanzapine
4'-Desmethylolanzapine |
P450; Drug Metabolite | Metabolism |
N-desmethyl Olanzapine 是一种非典型抗精神病化合物Olanzapinec 的代谢产物,是通过细胞色素 450(CYP)同工酶 CYP1A2 对奥氮平进行氧化代谢而形成的。 | |||
T7696 |
3-Cyano-7-ethoxycoumarin
|
Others | Others |
3-Cyano-7-ethoxycoumarin 是荧光色素 P-450底物,在酶切时获得蓝色荧光产物。 | |||
T73898 |
Paritaprevir dihydrate
|
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Paritaprevir (ABT-450) dihydrate,一种口服非结构蛋白3/4A (NS3/4A) 蛋白酶抑制剂,对HCV1a 和 1b 具有高效抗病毒活性,EC50值分别为1 nM 和 0.21 nM。此外,其作为SARS-CoV3CLpro 抑制剂,IC50为1.31 μM。其主要通过细胞色素P450 (CYP) 3A代谢,且利托那韦 (Ritonavir,CYP450 抑制剂) 能增强其血浆浓度和延长半衰期。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T1011 |
Itraconazole
伊曲康唑,R51211 |
P450; Hedgehog/Smoothened; Antibiotic; Autophagy; Antifungal | Autophagy; GPCR/G Protein; Metabolism; Microbiology/Virology; Stem Cells |
Itraconazole (R51211) 是三唑类抗真菌药,也是口服活性的Hedgehog 信号通路拮抗剂,IC50约为 800 nM。它也是 oxysterol-binding protein 抑制剂。它抑制羊毛甾醇 14α-脱甲基酶,从而抑制羊毛甾醇向麦角固醇的氧化转化。它有抗癌和抗血管作用。 | |||
T40859 |
5-Hydroxy-8-methoxypsoralen
5-Hydroxyxanthotoxin,5-Hydroxy-8-methoxypsoralen |
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5-Hydroxy-8-methoxypsoralen (5-Hydroxyxanthotoxin) is a metabolite derived from Xanthotoxin, which acts as a potent tricyclic furocoumarin suicide inhibitor of CYP (cytochrome P-450). It is employed as an agent for the treatment of psoriasis, eczema, vitiligo, and certain cutaneous Lymphomas, in combination with phototherapy involving exposure to sunlight. |