Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T39508 |
KY-02327
|
Others | Others |
KY-02327 是 KY-02061的一种类似物,具有代谢稳定性。KY-02327是Dishevelled (Dvl)-CXXC5相互作用抑制剂。KY-02327激活Wnt/β-catenin 途径,从而促进成骨细胞分化。 | |||
T9025 |
KY19382
2H-Indol-2-one, 5,6-dichloro-3-[1,3-dihydro-3-(methoxyimino)-2H-indol-2-ylidene]-1,3-dihydro-Ky19382,A3051 |
Others; GSK-3; Wnt/beta-catenin | Cytoskeletal Signaling; Others; PI3K/Akt/mTOR signaling; Stem Cells |
KY19382 (2H-Indol-2-one, 5,6-dichloro-3-[1,3-dihydro-3-(methoxyimino)-2H-indol-2-ylidene]-1,3-dihydro-Ky19382) 是一种具有口服活性的 CXXC5-DVL (IC50:19 nM) 和 GSK3β (IC50:10 nM) 的双重抑制剂。它通过对 CXXC5-DVL 相互作用和 GSK3β 活性的抑制作用激活 Wnt/β-catenin 信号传导。它可用于高脂饮食诱发的代谢性疾病的研究。 | |||
T62436 | KY-02327 acetate | ||
KY-02327 acetate 是一种有效的 Dishevelled (Dvl)-CXXC5相互作用抑制剂,是一种代谢稳定的 KY-02061 类似物。KY-02327 acetate 能够激活 Wnt/β-catenin 途径,进而促进成骨细胞分化。 | |||
T40950 |
A3334
|
||
A3051, is a robust and orally active inhibitor of CXXC5-DVL with an IC 50 of 63.06 nM. Its applications include research into phenotypes associated with obesity, diabetes, and NASH that are induced by high fat diet (HFD) and methionine-choline deficient diet (MCD). |