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Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T78569 |
CPT2
Carnitine palmitoyltransferase 2 |
Apoptosis | Apoptosis |
CPT2 (Carnitine palmitoyltransferase 2) 是一种脂肪酸氧化过程中的酶,它在结直肠癌 (CRC) 预后评估中作为生物标志物。CPT2 通过过表达激活p-p53并增加p53蛋白水平,这有助于抑制肿瘤生长和促进细胞的凋亡。CPT2 缺乏是长链脂肪酸氧化障碍相关的常见遗传性疾病,并且CPT2 的表达降低与多种癌症的发展密切相关,因此,在癌症研究领域具有研究价值。 | |||
T15020 |
CU-CPT22
|
TLR | Immunology/Inflammation |
CU-CPT22 是 toll 样受体 1 和 2 蛋白复合物抑制剂,可阻断 Pam3CSK4诱导的 TLR1/2 激活,IC50值为 0.58 µM。 它与 TLR1/2 结合的合成三酰脂蛋白竞争,Ki 值为 0.41 µM。 | |||
T12408 |
Perhexiline maleate
|
Others; Mitochondrial Metabolism | Metabolism; Others |
Perhexiline maleate 是一种口服活性的 CPT1和 CPT2抑制剂,可降低脂肪酸的代谢。Perhexiline maleate 对大鼠心脏和肝脏CPT 1的IC50值分别为77 和 148 μM。 | |||
T60510 |
Perhexiline
|
||
Perhexiline 是一种口服活性的 CPT1和 CPT2抑制剂,可降低脂肪酸的代谢。Perhexiline 可以穿过血脑屏障 (BBB)具有抗癌活性。Perhexiline 诱导肝细胞中的线粒体功能障碍和细胞凋亡。因此,Perhexiline 可用于研究癌症和心绞痛等心血管疾病。 |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPH-01050 |
CPT2 Protein, Human, Recombinant (His & Myc)
Carnitine O-palmitoyltransferase 2, mitochondrial,<... |
Human | E. coli |
Involved in the intramitochondrial synthesis of acylcarnitines from accumulated acyl-CoA metabolites. Reconverts acylcarnitines back into the respective acyl-CoA esters that can then undergo beta-oxidation, an essential step for the mitochondrial uptake of long-chain fatty acids and their subsequent beta-oxidation in the mitochondrion. Active with medium (C8-C12) and long-chain (C14-C18) acyl-CoA esters. CPT2 Protein, Human, Recombinant (His & Myc) is expressed in E. coli expression system with ... | |||
TMPH-03329 |
Mcpt2 Protein, Rat, Recombinant (His & Myc)
|
Rat | E. coli |
This enzyme, isolated from small intestine, specifically inactivates the apo forms of a certain group of intracellular pyridoxal phosphate-requiring enzymes. It has chymotrypsin-like specificity towards small substrates. Mcpt2 Protein, Rat, Recombinant (His & Myc) is expressed in E. coli expression system with N-6xHis and C-Myc tag. The predicted molecular weight is 30.5 kDa and the accession number is P00770. |