Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T10870L |
CP-547632
|
VEGFR; FGFR; PDGFR; BTK | Angiogenesis; Tyrosine Kinase/Adaptors |
CP-547632是一种可口服且具有有效性、ATP 竞争性的 血管内皮生长因子受体2(VEGFR-2 )和 碱性成纤维细胞生长因子(FGF)激酶F 双重抑制剂,IC50 分别为 11 nM 和 9 nM。CP-547632具有选择性,对 VEGFR2 和 bFGF 的选择性高于 EGFR,PDGFRβ 和相关的酪氨酸激酶 (TKs) 。 CP-547632具有抗肿瘤活性。 | |||
T10870 |
CP-547632 hydrochloride
|
FGFR | Angiogenesis; Tyrosine Kinase/Adaptors |
CP-547632 hydrochloride is a well-tolerated and orally-bioavailable inhibitor of the VEGFR-2 and basic FGF kinases (IC50s: 11 nM and 9 nM) with antitumor efficacy. |