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抑制剂 & 化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T7373	CDN1163	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	CDN1163 是肌膜/内质网 Ca2+-ATPase (SERCA)的变构激活剂，可改善 Ca2+稳态，可减轻糖尿病和代谢紊乱。
T74693	CDN-A
	CDN-A为一种环二核苷酸，主要用于抗体-活性分子偶联物(ADC)的合成。作为先天免疫及适应性免疫反应的关键激活剂，环状二核苷酸能由内源性外来DNA或侵入性细菌病原体生成，在人体内通过促进干扰素基因表达激活先天免疫系统。
T81870	Mal-VC-PAB-PNP-CDN-A
	Mal-VC-PAB-PNP-CDN-A是一种ADC活性分子与linker偶联物，具有特定的生物化学功能。
T9137	SN-011 [1,1'-Biphenyl]-4-carboxamide, N-[3-[[(4-fluorophenyl)sulfonyl]amino]-4-hydroxyphenyl]-,GUN35901	STING	Immunology/Inflammation
	SN-011 (GUN35901) 是选择性 STING 抑制剂，可与环状二核苷酸 (CDN) 竞争 STING 二聚体的结合口袋，从而阻断 CDN 结合和 STING 激活。它用于 STING 驱动的自身免疫和炎症性疾病的研究，抑制 STING 信号传导的 IC50值为 76 nM。
T79313	BI 7446	STING	Immunology/Inflammation
	BI 7446 是一种基于环状二核苷酸 (CDN) 的高效、特异性STING (干扰素基因刺激蛋白) 激动剂。它能激活所有五种STING变体并在体外诱导肿瘤特异性的免疫介导反应，从而消除肿瘤。此化合物适用于免疫肿瘤学领域的研究。
T36985	Cyclic di-UMP (sodium salt)
	Cyclic di-UMP is a pyrimidine-containing cyclic dinucleotide (CDN).1It is produced by bacterial cGAS/DncV-like nucleotidyltransferases (CD-NTases), such as LpCdnE02 fromL. pneumophila, and binds to cGAS, in the apo or dsDNA-bound forms, with reduced affinity compared to 2'3'-cGAMP or 3'3'-cGAMP .1,2Cyclic di-UMP is intended for use as a negative control for cyclic di-GMP signaling. 1.Whiteley, A.T., Eaglesham, J.B., de Oliveira Mann, C.C., et al.Bacterial cGAS-like enzymes synthesize diverse nuc...
T35654	2'2'-cGAMP (sodium salt)
	2'2'-cGAMP is a synthetic dinucleotide (CDN) that contains non-canonical 2'5'-phosphodiester bonds. It binds to the adapter protein stimulator of interferon genes , which is a component of the innate immune response that activates the type I interferon pathway when bound to cyclic dinucleotides. 2'2-cGAMP shows weaker binding to STING than 2'3'-cGAMP but binds more strongly than 3'3'-cGAMP , cyclic di-GMP , or 3'2'-cGAMP, which bind in the micromolar range (Kds = 1.04, 1.21, or 1.61 μM, respecti...

化合物

CDN1163

Cat.No: T7373

Synonym:

Target: Calcium Channel

Mal-VC-PAB-PNP-CDN-A

Synonym: [1,1'-Biphenyl]-4-carboxamide, N-[3-[[(4-fluorophenyl)sulfonyl]amino]-4-hydroxyphenyl]-,GUN35901

Cyclic di-UMP (sodium salt)

Cat.No: T36985

Synonym:

Target:

2'2'-cGAMP (sodium salt)

Cat.No: T35654

Synonym:

Target:

Cat. No.	Product Name	Target	Signaling Pathways
T13606L	cGAMP disodium
	cGAMP disodium 是在细菌中发现的一种环二核苷酸 (CDN) ，可作为内源性第二信使，影响干扰素的产生以响应胞浆 DNA。cGAMP disodium 通过激活干扰素基因刺激因子 (STING)使 I 型干扰素和其他免疫介质的信号产生级联现象。cGAMP disodium 是一种有效的舌下免疫佐剂，能使免疫功能（血清抗 PA 中和和气道分泌物抗 PA SIgA 反应）更好的发挥作用。