Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T40264 |
CDK7-IN-7
CDK7-IN-7 |
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CDK7-IN-7, a highly potent and selective inhibitor of CDK7 kinase, exhibits remarkable activity with an IC50 of less than 50 nM. | |||
T40353 |
CDK7/9-IN-1
CDK7/9-IN-1 |
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CDK7/9-IN-1 is a specific inhibitor of cyclin-dependent kinases 7/9 (CDK7/9). It specifically targets CDK7, while also displaying inhibitory activity against CDK9. CDK7/9-IN-1 demonstrates excellent inhibitory potency against CDK7, with IC50 values of 0.0656 μM and 0.00574 μM without pre-incubation and after 3 hours pre-incubation, respectively. Furthermore, CDK7/9-IN-1 inhibits CDK9 with an IC50 of 2.14 μM after 3 hours pre-incubation. Its application in cancer research makes it valuable for su... | |||
T39247 |
CDK7-IN-5
CDK7-IN-5 |
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CDK7-IN-5, a CDK7 inhibitor with an IC 50 value of less than 100 nM, exhibits potent anticancer properties (WO2015154022A1, Compound 104). | |||
T39943 |
CDK7-IN-6
CDK7-IN-6 |
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CDK7-IN-6 is a highly effective and specific inhibitor (IC50 ≤100 nM) of cyclin-dependent kinase 7 (CDK7). It showcases remarkable selectivity, with more than a 200-fold preference for CDK7 over CDK1, CDK2, and CDK5. This compound holds significant potential for cancer research purposes. | |||
T39372 |
CDK7-IN-1
CDK7-IN-1 |
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CDK7-IN-1 is an analog derived from YKL-5-124 and functions as an inhibitor of cyclin-dependent kinase 7 (cdk7). It exhibits strong inhibitory activity, with an IC50 value of less than 100 nM (WO 2016105528 A2, Compound 215). | |||
T39864 |
CDK7-IN-2 hydrochloride hydrate
CDK7-IN-2 hydrochloride hydrate |
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CDK7-IN-2 hydrochloride hydrate (Example 6) is a highly effective and specific inhibitor of the CDK7 enzyme. This compound exhibits significant anti-cancer properties. | |||
T62791 | CDK7-IN-16 | ||
CDK7-IN-16 (compound 9) 是一种 CDK 7 的有效抑制剂 (IC50: 1-10 nM)。CDK7-IN-16 能够用于研究抗癌,特别是转录异常的癌症。 | |||
T82227 |
HDAC1/CDK7-IN-1
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HDAC | Chromatin/Epigenetic; DNA Damage/DNA Repair |
HDAC1/CDK7-IN-1(compound 8e)是一款针对CDK7和HDAC1的双重抑制剂,其IC50值分别为893 nM 和248 nM 。该化合物能有效抑制MDA-MB-231、MCF-7、A549及HCT-116等多种癌细胞系的生长。此外,HDAC1/CDK7-IN-1在HCT-116细胞中诱发了细胞周期阻滞与凋亡(apoptosis)现象,并能够抑制其细胞迁移能力。 | |||
T79881 |
CDK7-IN-25
|
CDK | Cell Cycle/Checkpoint |
CDK7-IN-25 (CY-16-1)为一CDK-7抑制剂,具有极低的半抑制浓度(IC50<1nM),主要用于癌症研究领域。 | |||
T73163 | CDK7-IN-20 | ||
CDK7-IN-20 是一种有效的、选择性的、不可逆的 CDK7(CDK) 抑制剂,IC50值为 4 nM。CDK7-IN-20 对 CDK7的选择性超过 CDK1、CDK2、CDK3、CDK5、CDK6、CDK9 和 CDK12的 206 倍以上。CDK7-IN-20 具有用于常染色体显性多囊肾病 (ADPKD) 研究的潜力。 |