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Cat. No.	Product Name	Target	Signaling Pathways
T39372	CDK7-IN-1 CDK7-IN-1
	CDK7-IN-1 is an analog derived from YKL-5-124 and functions as an inhibitor of cyclin-dependent kinase 7 (cdk7). It exhibits strong inhibitory activity, with an IC50 value of less than 100 nM (WO 2016105528 A2, Compound 215).
T7296	THZ2 CDK7-IN-1	CDK	Cell Cycle/Checkpoint
	THZ2 (CDK7-IN-1) 是 THZ1 的类似物，是一种有效的选择性 CDK7 抑制剂，IC50值为 13.9 nM。它有治疗三阴性乳腺癌的潜力。
T40353	CDK7/9-IN-1 CDK7/9-IN-1
	CDK7/9-IN-1 is a specific inhibitor of cyclin-dependent kinases 7/9 (CDK7/9). It specifically targets CDK7, while also displaying inhibitory activity against CDK9. CDK7/9-IN-1 demonstrates excellent inhibitory potency against CDK7, with IC50 values of 0.0656 μM and 0.00574 μM without pre-incubation and after 3 hours pre-incubation, respectively. Furthermore, CDK7/9-IN-1 inhibits CDK9 with an IC50 of 2.14 μM after 3 hours pre-incubation. Its application in cancer research makes it valuable for su...
T82227	HDAC1/CDK7-IN-1	HDAC	Chromatin/Epigenetic; DNA Damage/DNA Repair
	HDAC1/CDK7-IN-1（compound 8e）是一款针对CDK7和HDAC1的双重抑制剂，其IC50值分别为893 nM 和248 nM 。该化合物能有效抑制MDA-MB-231、MCF-7、A549及HCT-116等多种癌细胞系的生长。此外，HDAC1/CDK7-IN-1在HCT-116细胞中诱发了细胞周期阻滞与凋亡（apoptosis）现象，并能够抑制其细胞迁移能力。
T62926	CDK7/12-IN-1
	CDK7/12-IN-1 是一种 CDK7/12 的选择性抑制剂，作用于 CDK7 (IC50: 3 nM) 和 CDK 12 (IC50: 277 nM)。抑制 CDK7 和 CDK12 是一种有效抑制肿瘤生长的有效。
T79169	CDK7-IN-22	CDK	Cell Cycle/Checkpoint
	CDK7-IN-22 (compound 101)为CDK7选择性抑制剂，具备抗肿瘤活性。
T75121	CDK7-IN-21
	CDK7-IN-21 (compound A22) 是一种有效的 CDK7抑制剂。
T62791	CDK7-IN-16
	CDK7-IN-16 (compound 9) 是一种 CDK 7 的有效抑制剂 (IC50: 1-10 nM)。CDK7-IN-16 能够用于研究抗癌，特别是转录异常的癌症。
T79881	CDK7-IN-25	CDK	Cell Cycle/Checkpoint
	CDK7-IN-25 (CY-16-1)为一CDK-7抑制剂，具有极低的半抑制浓度(IC50<1nM)，主要用于癌症研究领域。
T36743	CDK7/9 tide
	CDK7/9 tide is peptide substrate for CDK7 or CDK9[1]. [1]. Robert T, et, al. Development of a CDK10/CycM in vitro Kinase Screening Assay and Identification of First Small-Molecule Inhibitors. Front Chem. 2020 Feb 27; 8:147.
T14915	CDK12-IN-E9	CDK	Cell Cycle/Checkpoint
	CDK12-IN-E9 is a potent and selective covalent CDK12 inhibitor and non-covalent CDK9 inhibitor while avoiding ABC transporter-mediated efflux. It has a weak binding ability to CDK7/CyclinH complex (IC50> 1 μM).
T79604	SHR5428	CDK	Cell Cycle/Checkpoint
	SHR5428为口服选择性非共价CDK7抑制剂，显示出高效CDK7酶活性抑制（IC50=2.3 nM）。它还有效抑制MDA-MB-468细胞系中的三阴性乳腺癌细胞活性（IC50=6.6 nM）。
T70988	Ibulocydine
	Ibulocydine is a potent CDK inhibitor. Ibulocydine has high activity against Cdk7/cyclin H/Mat1 and Cdk9/cyclin T. Ibulocydine inhibited the growth of HCC cells more effectively than other Cdk inhibitors, including olomoucine and roscovitine, whereas ibulocydine as well as the other Cdk inhibitors and BMK-Y101 minimally influenced the growth of normal hepatocyte cells. Ibulocydine induced apoptosis in HCC cells, most likely by inhibiting Cdk7 and Cdk9. In vitro treatment of HCC cells with ibuloc...

化合物

Cat.No: T39372

Synonym: CDK7-IN-1

Cat.No: T7296

Synonym: CDK7-IN-1

Target: CDK

Cat.No: T40353

Synonym: CDK7/9-IN-1

HDAC1/CDK7-IN-1

Cat.No: T82227

Target: HDAC

Cat.No: T62926

Cat.No: T79169

Target: CDK

Cat.No: T75121

Cat.No: T62791

Cat.No: T79881

Target: CDK

Cat.No: T36743

Cat.No: T14915

Target: CDK

Cat.No: T79604

Target: CDK

Cat.No: T70988

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