搜索结果

Search Results for " cdc25c "

抑制剂 & 化合物

天然产物

如果没找到您满意的产品或者您对产品有其他要求，可以联系我们专业顾问为您提供针对性的合理建议。 QQ咨询网站留言咨询

Cat. No.	Product Name	Target	Signaling Pathways
T4671	BN82002 CDC25 Phosphatase Inhibitor I	Phosphatase	Metabolism
	BN82002 (CDC25 Phosphatase Inhibitor I) 是一种CDC25 phosphatase 家族的有效的、不可逆的、选择性的泛抑制剂。它显示出比 CD45 酪氨酸磷酸酶高约 20 倍的选择性。
T16357	DA-3003-1 NSC 663284	Phosphatase	Metabolism
	DA-3003-1 (DA-3003-1) 是一种可渗透进细胞膜且具有有效性和选择性的 Cdc25 dual specificity phosphatase 抑制剂，具有抗肿瘤活性，对 Cdc25B2、Cdc25A、Cdc25B2 和 Cdc25C具有抑制作用。
T7078	NSC 95397	Apoptosis; Phosphatase	Apoptosis; Metabolism
	NSC 95397 是一种选择性的Cdc25双特异性磷酸酶抑制剂。它抑制丝裂原活化蛋白激酶磷酸酶-1(MKP-1)，通过 MKP-1 和 ERK1/2 途径抑制结肠癌细胞的增殖并诱导细胞凋亡。
T11929	M2N12	Phosphatase	Metabolism
	M2N12 是一种高度选择性的细胞分裂周期蛋白磷酸酶 25C 抑制剂，IC50值为 0.09 μM。它还抑制 Cdc25A 和 Cdc25B 的活性，IC50值分别为 0.53 μM 和 1.39 μM。它具有抗肿瘤活性，可研究癌症。
T12263L	NSC305787 hydrochloride (Rac)-NSC305787 hydrochloride	Others	Others
	NSC305787 hydrochloride ((Rac)-NSC305787 hydrochloride) 是一种可透过细胞膜且具有选择性和有效性的小分子 Cdc25 dual specificity phosphatase 和 EZR 双重抑制剂，在胰腺癌细胞中显示出抗肿瘤活性，对Cdc25B2， Cdc25A，Cdc25B2 和 Cdc25C 具有抑制作用。NSC 663284 抑制 NSD2 (IC50 of 170 nM) 酶的活性。
T69091	CBP501
	CBP501 is a peptide with G2 checkpoint-abrogating activity. G2 checkpoint inhibitor CBP501 inhibits multiple serine/threonine kinases, including MAPKAP-K2, C-Tak1, and CHK1, that phosphorylate serine 216 of the dual-specific phosphatase Cdc25C (cell division checkpoint 25 C); disruption of Cdc25C activity results in the inhibition of Cdc25C dephosphorylation of the mitotic cyclin-dependent kinase complex Cdc2/cyclin B, preventing entry into the mitotic phase of the cell cycle.
T38447	BN82002 hydrochloride
	BN82002 hydrochloride is a potent, selective, and irreversible inhibitor of the CDC25 phosphatase family. It inhibits CDC25A, CDC25B2, CDC25B3, CDC25C, and 25C-cat with IC50 values of 2.4, 3.9, 6.3, 5.4, and 4.6 μM, respectively. Additionally, BN82002 hydrochloride exhibits approximately 20-fold greater selectivity over CD45 tyrosine phosphatase.
T73526	M5N36
	M5N36 是一种有效的选择性Cdc25C 抑制剂，对 Cdc25A、Cdc25B、Cdc25C 的IC50值分别为 0.15、0.19、0.06 µM。M5N36 显示出抗增殖活性并增加 p-CDK1 和 p-CDK2 的表达。
T16848	SB-218078	Chk; PKC	Cell Cycle/Checkpoint; Chromatin/Epigenetic; Cytoskeletal Signaling
	SB-218078 is less potently inhibits Cdc2 (IC50: 250 nM) and PKC (IC50: 1000 nM). SB-218078 is a potent, ATP-competitive, and cell-permeable checkpoint kinase 1 inhibitor that inhibits Chk1 phosphorylation of cdc25C (IC50: 15 nM).
T71217	MPT0B214
	MPT0B214 is a novel and potent microtubule inhibitor with potential anticancer activity. MPT0B214 inhibited tubulin polymerization through strongly binding to the tubulin's colchicine-binding site and had cytotoxic activity in a variety of human tumor cell lines. After treatment with MPT0B214, KB cells were arrested in the G2-M phase before cell death occurred, which were associated with upregulation of cyclin B1, dephosphorylation of Cdc2, phosphorylation of Cdc25C and elevated expression of th...

化合物

BN82002

Cat.No: T4671

Synonym: CDC25 Phosphatase Inhibitor I

Target: Phosphatase

DA-3003-1

Cat.No: T16357

Synonym: NSC 663284

Target: Phosphatase

NSC 95397

Cat.No: T7078

Synonym:

Target: Apoptosis, Phosphatase

M2N12

Cat.No: T11929

Synonym:

Target: Phosphatase

NSC305787 hydrochloride

Cat.No: T12263L

Synonym: (Rac)-NSC305787 hydrochloride

BN82002 hydrochloride

Cat. No.	Product Name	Target	Signaling Pathways
TN5639	Rocaglaol Ferrugin,Aglaiastatin A
	Rocaglaol is a potent anticancer drug that induces apoptosis of LNCaP cells through the mitochondrial pathway and its G2/M-phase cell cycle arrest is associated with the down-regulation of Cdc25C and the dephosphorylation of Cdc2. Rocaglaol can reduce tis

天然产物

Rocaglaol

Cat.No: TN5639

Synonym: Ferrugin,Aglaiastatin A

Target:

* 搜索：		* 机关/企业：
* 邮箱：		* 电话：
备注：
验证码：

搜索结果

抑制剂 & 化合物

天然产物

提交您的定制咨询

化合物

天然产物