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抑制剂 & 化合物

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T70927	UCD74A HCl
	UCD74A HCl is a cell impermeant homolog of UCD38B, inhibitor of uPA (urokinase plasminogen activator).
T77478	Milatuzumab hLL1,MEDI-115	Others	Others
	Milatuzumab (MEDI-115) 是一种人源化抗 CD74 单克隆抗体。Milatuzumab 促使自由基氧的产生和线粒体膜电位的丧失，可降低 CD20/CD74 聚集体和细胞粘附，诱导细胞死亡。
T38293	4-CPPC	Others	Others
	4-CPPC 是一种巨噬细胞迁移抑制因子 2 (MIF-2; IC50= 27 μM) 的抑制剂。它对 MIF-2 的选择性高于 MIF-1 (IC50= 450 μM)。当以 10 μM 浓度使用时，它在体外抑制 MIF-2，但不抑制 MIF-1，与 CD74 结合。 4-CPPC（5、10 和 25 μM）抑制原代人皮肤成纤维细胞中 MIF-2 诱导的 ERK1/2 磷酸化。
T79706	TRK-IN-24	Trk receptor	Tyrosine Kinase/Adaptors
	TRK-IN-24（compound 10g）是一种针对Trk Receptor的抑制剂，它对TRKA、TRKC、TRKAG595R、TRKAG667C和TRKAF589L的抑制作用的IC50值分别达到5.21、4.51、6.77、1.42和6.13 nM。该化合物在BaF3-CD74-NTRK1G595R和BaF3-CD74-NTRK1G667C异种移植模型中显示出明显的抗肿瘤活性。此外，TRK-IN-24 能有效抑制携带SF、GK、xDFG等单点突变的Ba/F3细胞增殖，其IC50范围为1.43至47.56 nM。
T72289	Type II TRK inhibitor 1	Trk receptor	Tyrosine Kinase/Adaptors
	Type II TRK inhibitor 1 是有效抑制多种TRK融合蛋白及野生型的TRK抑制剂。对携有CD74-TRKAG667C及ETV6-TRKCG696C融合蛋白的Ba/F3细胞表现出抗增殖活性，其IC50值分别为6 nM与1.7 nM。

化合物

Synonym: hLL1,MEDI-115

Target: Trk receptor

Type II TRK inhibitor 1

Cat.No: T72289

Synonym:

Target: Trk receptor

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-01199	CD74 Protein, Human, Recombinant (His) II,DHLAG,Ia-GAMMA,CD74 molecule, major his...	Human	HEK293 Cells
	CD74 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 20.4 kDa and the accession number is P04233-2.
TMPY-06680	CD74 Protein, Mouse, Recombinant (His) HLADG,CLIP,Ii,CD74 molecule, major histoco...	Mouse	HEK293 Cells
	CD74 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 26.82 kDa and the accession number is P04441.
TMPJ-00775	CD74 Protein, Mouse, Recombinant (mFc & His) HLA class II histocompatibility antigen γ chain,HLA-DR antig...	Mouse	HEK293 Cells
	Mouse HLA class II histocompatibility antigen gamma chain (CD74), is a single-pass type II membrane protein that in humans is encoded by the CD74 gene. It contains 1 thyroglobulin type-1 domain. CD74 Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to compartments where peptide loading of class II takes place.
TMPK-00864	DDT Protein, Human, Recombinant (His) Phenylpyruvate tautomerase II,D-dopachrome tautomerase,D-DT,...	Human	E. coli
	D-dopachrome tautomerase (D-DT) is a newly described cytokine and a member of the macrophage migration inhibitory factor (MIF) protein superfamily.The D-DT protein also is present in most tissues and circulates in serum at similar concentrations as MIF. D-DT binds the MIF cell surface receptor complex, CD74/CD44, with high affinity and induces similar cell signaling and effector functions. DDT Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-His tag. The predict...
TMPK-00722	DDT Protein, Mouse, Recombinant (His) DDCT,D-dopachrome tautomerase,MIF2,Phenylpyruvate tautomeras...	Mouse	E. coli
	D-dopachrome tautomerase (D-DT) is a newly described cytokine and a member of the macrophage migration inhibitory factor (MIF) protein superfamily.The D-DT protein also is present in most tissues and circulates in serum at similar concentrations as MIF. D-DT binds the MIF cell surface receptor complex, CD74/CD44, with high affinity and induces similar cell signaling and effector functions. DDT Protein, Mouse, Recombinant (His) is expressed in E. coli expression system with N-His tag. The predict...
TMPK-01307	DDT Protein, Cynomolgus, Recombinant (His) MIF2,D-dopachrome decarboxylase,DDCT,D-DT,EC 4.1.1.84,D-dopa...	Cynomolgus	E. coli
	D-dopachrome tautomerase (D-DT) is a newly described cytokine and a member of the macrophage migration inhibitory factor (MIF) protein superfamily.The D-DT protein also is present in most tissues and circulates in serum at similar concentrations as MIF. D-DT binds the MIF cell surface receptor complex, CD74/CD44, with high affinity and induces similar cell signaling and effector functions. DDT Protein, Cynomolgus, Recombinant (His) is expressed in E. coli expression system with N-His tag. The pr...
TMPK-01257	DDT Proten, Canine, Recombinant (His) EC 4.1.1.84,DDCT,D-DT,MIF2	Canine	E. coli
	D-dopachrome tautomerase (D-DT) is a newly described cytokine and a member of the macrophage migration inhibitory factor (MIF) protein superfamily.The D-DT protein also is present in most tissues and circulates in serum at similar concentrations as MIF. D-DT binds the MIF cell surface receptor complex, CD74/CD44, with high affinity and induces similar cell signaling and effector functions. DDT Proten, Canine, Recombinant (His) is expressed in E. coli expression system with N-His tag. The predict...