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Targets Recommended: Immunology/Inflammation related Interleukin

抑制剂 & 化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T76883	Talacotuzumab CSL 362,JNJ 56022473	Immunology/Inflammation related; Interleukin	Immunology/Inflammation
	Talacotuzumab (JNJ 56022473) 是一种含有修饰的 Fc 结构的IgG1 型完全人源化的 CD123 中和单克隆抗体。Talacotuzumab 对 CD123、CD32b/c、CD16-158F、CD16-158V 具有很高的亲和力， KD 分别为 0.43 nM、188 nM、46 nM、16.8 nM。Talacotuzumab 通过抑制 IL-3 与 CD123 结合进而抑制靶细胞中的 IL-3 信号传导。Talacotuzumab 诱导 Fc 区发生突变以增加对 CD16 (FcγRIIIa) 的亲和力，从而加强抗体依赖性细胞介导的细胞毒性 (ADCC)。Talacotuzumab 急性髓性白血病 (AML) 异种移植小鼠模型中抑制白血病细胞生长。

化合物

Talacotuzumab

Cat.No: T76883

Synonym: CSL 362,JNJ 56022473

Target: Immunology/Inflammation related, Interleukin

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-01985	CD32B/Fcgr2b Protein, Human, Recombinant (His & Avi), Biotinylated FCGR2,FCGR21,CD32A,FCG2,CDw32,CD<...	Human	HEK293 Cells
	CD32B/Fcgr2b Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 24 kDa and the accession number is P31994-2.
TMPY-00800	CD32B/Fcgr2b Protein, Mouse, Recombinant (His) Fc fragment of IgG, low affinity IIb, receptor (CD3...	Mouse	HEK293 Cells
	CD32B/Fcgr2b Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 21.7 kDa and the accession number is A0A0B4J1E6.
TMPK-00200	Fc gamma RIIB/CD32b Protein, Human, Recombinant (His & Avi), Biotinylated Fc γ RII,FCG2,FCGR2,Fc gamma RIIB,CD32,Fc gamma RII...	Human	HEK293 Cells
	Fc gamma RIIB/CD32b Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 22.5 kDa and the accession number is P31994-1.
TMPK-00199	Fc gamma RIIB/CD32b Protein, Human, Recombinant (His & Avi) CDw32,Fc γ RIIB,Fc gamma RIIB,Fc γ RII,FCG2,IGFR2,F...	Human	HEK293 Cells
	The Fc gamma Rs have been divided into three classes based on close relationships in their extracellular domains; these groups are designated Fc gamma RI (also known as CD64), Fc gamma RII (CD32), and Fc gamma RIII (CD16). Each group may be encoded by multiple genes and exist in different isoforms depending on species and cell type. Fc gamma RIIB/CD32b Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 22.5 kDa and...
TMPY-01990	CD32B/Fcgr2b Protein, Cynomolgus, Recombinant (His & Avi), Biotinylated Fc fragment of IgG, low affinity IIb, receptor (CD3...	Cynomolgus	HEK293 Cells
	CD32B/Fcgr2b Protein, Cynomolgus, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 23.5 kDa and the accession number is Q8SPW3.
TMPY-00765	CD32B/Fcgr2b Protein, Human, Recombinant (His) IGFR2,FCGR21,Fc γ RIIB,Fc gamma RIIB,FcGR,CD32A,	Human	HEK293 Cells
	CD32B/Fcgr2b Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 20.8 kDa and the accession number is P31994-2.
TMPJ-00192	CD32B Protein, Human, Recombinant (His) FCG2,IgG Fc Receptor II-b,CDw32,Low Affinity Immuno...	Human	HEK293 Cells
	FcγRIIB is a low affinity receptor that recognizes the Fc portion of IgG. The human CD32 group consists of FcγRIIA, FcγRIIB, and FcγRIIC proteins that share 94-99% sequence identity in their extracellular domains but differ substantially in their transmembrane and cytoplasmic domains. FcγRII protein is expressed on cells of both myeloid and lymphoid lineages as well as on cells of non-hematopoietic origin. FcγRIIB has an intrinsic cytoplasmic immunoreceptor tyrosine-based inhibitory motif (ITIM)...
TMPY-02052	CD32B/Fcgr2b Protein, Rat, Recombinant (His) Fc fragment of IgG, low affinity IIb, receptor (CD3...	Rat	HEK293 Cells
	CD32B/Fcgr2b Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 21.9 kDa and the accession number is Q63203-1.
TMPJ-00803	CD32B Protein, Mouse, Recombinant (His) Fcgr2,Fcgr2b,Fc-γ-RIIB,Fc-γ RII,Low affinity immunoglobulin ...	Mouse	HEK293 Cells
	Low affinity immunoglobulin gamma Fc region receptor II (CD32B) is a single-pass type I membrane protein and contains 2 Ig-like C2-type (immunoglobulin-like) domains. The inhibitory CD32B is expressed on B cells and myeloid dendritic cells. Ligation of CD32B on B cells downregulates antibody production and may, in some circumstances, promote apoptosis. Co-ligation of CD32B on dendritic cells inhibits maturation and blocks cell activation. CD32B may also be a target formonoclonal antibody therap...
TMPY-01971	CD32B/Fcgr2b Protein, Cynomolgus, Recombinant (His) Fc fragment of IgG, low affinity IIb, receptor (CD3...	Cynomolgus	HEK293 Cells
	CD32B/Fcgr2b Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 20.9 kDa and the accession number is Q8SPW3.
TMPY-01986	CD32B/Fcgr2b Protein, Mouse, Recombinant (His & Avi), Biotinylated Fcgr2a,Fc fragment of IgG, low affinity IIb, receptor (C...	Mouse	HEK293 Cells
	CD32B/Fcgr2b Protein, Mouse, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 23.9 kDa and the accession number is A0A0B4J1E6.