Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T13114 |
CCR2 antagonist 4
Teijin compound 1 |
CCR | Immunology/Inflammation; Microbiology/Virology |
CCR2 antagonist 4 (Teijin compound 1) 是高效的、特异性的CCR2拮抗剂,对 CCR2b 的IC50为 180 nM,抑制 MCP-1 诱导的趋化作用的 IC50为 24 nM。 | |||
T10713 | CCR4 antagonist 2 | Calcium Channel | Membrane transporter/Ion channel; Metabolism |
CCR4 antagonist 2 (Compound 31) is a novel potent, orally bioavailable small molecule antagonists of CC chemokine receptor 4 (CCR4) that inhibits Treg trafficking into the Tumor Microenvironment without suppressing the number of Treg in healthy tissues. CCR4 antagonist 2 (Compound 31) exhibits IC50 values of Ca2+flux and (chemotaxis) CTX are 40 nM and 70 nM, respectively. | |||
T19230 |
CCR2 antagonist 4 hydrochloride
Teijin compound 1 hydrochloride |
Others | Others |
CCR2 antagonist 4 hydrochloride is a specific CCR2 antagonist (IC50s: 180 nM for CCR2b). It potently inhibits MCP-1-induced chemotaxis (IC50: 24 nM). |