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Search Results for " c5b "

Targets Recommended: Complement System

6

抑制剂 & 化合物

9

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T9915	Eculizumab	Complement System	Immunology/Inflammation
	Eculizumab 是针对补体 C5 的长效人源化单克隆抗体。它对 C5 裂解为 C5a 和 C5b 具有抑制作用，并抑制了末端补体系统的部署，其中包括膜攻击复合物的形成。它可用于溶血的研究。
T64611	Acetyl-Histone H3 (Lys9) (C5B11) Rabbit mAb #9649R
	Acetyl-Histone H3 (Lys9) (C5B11) Rabbit mAb #9649R 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T64611。
T31877	Freselestat ONO-PO 736,ONO-6818,ONO 6818,ONO6818
	Freselestat (ONO-6818) is a potent neutrophil elastase inhibitor that significantly reduces the production of interleukin 8 and C5B-9. Freselestat reduces inflammatory mediators during simulated cardiopulmonary bypass.
T74551	Avacincaptad pegol sodium
	Avacincaptad pegol (ARC1905) 是一种靶向补体因子5 (C5)的核酸适配体，抑制C5剪切为C5a 和C5b。Avacincaptad pegol 被用于研究与年龄相关的黄斑变性(AMD)。
T74552	Non-PEGylated/naked ARC1905
	Non-PEGylated/naked ARC1905 是一种没有偶联PEG 的靶向补体因子5 (C5)的核酸适配体，抑制C5剪切为C5a 和C5b。Non-PEGylated/naked ARC1905 被用于研究与年龄相关的黄斑变性(AMD)。
T77190	Crovalimab
	Crovalimab (SKY59; RO7112689)是一种人源化抗C5抗体，其通过pH依赖性机制发挥作用，其KD值在pH 7.4时为15.2nM，在pH 5.8时为16.8μM。该化合物还以高亲和力结合于人FcRn(KD: 17μM; pH 6.0)。通过阻断C5转化酶对C5的切割及抑制C5变体(p.Arg885His)的活性，Crovalimab能够显著抑制补体系统中经典途径(CP)、凝集素途径(LP)以及旁路途径(AP)中C5b-9的形成。因此，Crovalimab展现出作为研究阵发性睡眠性血红蛋白尿(PNH)及其他补体介导疾病的潜力。

化合物

Cat.No: T9915

Target: Complement System

Acetyl-Histone H3 (Lys9) (C5B11) Rabbit mAb #9649R

Cat.No: T64611

Cat.No: T31877

Synonym: ONO-PO 736,ONO-6818,ONO 6818,ONO6818

Avacincaptad pegol sodium

Cat.No: T74551

Non-PEGylated/naked ARC1905

Cat.No: T74552

Cat.No: T77190

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-05057	Complement C5 Protein, Human, Recombinant (His & FLAG) C5b,ECLZB,C5a,CPAMD4,C5D,complement component 5,Com...	Human	HEK293 Cells
	Complement C5 Protein, Human, Recombinant (His & FLAG) is expressed in HEK293 mammalian cells with His and Flag tag. The predicted molecular weight is 188.8 kDa and the accession number is P01031.
TMPY-00653	Complement C5 Protein, Human, Recombinant (Complement C5a) C5D,C5b,CPAMD4,complement component 5,Complement C5...	Human	E. coli
	Complement C5 Protein, Human, Recombinant (Complement C5a) is expressed in E. coli expression system. The predicted molecular weight is 8.3 kDa and the accession number is P01031.
TMPY-06814	Complement C5 Protein, Human, Recombinant (Flag) C5a,CPAMD4,ECLZB,C5b,C5D,Complement C5,complement c...	Human	HEK293 Cells
	Complement C5 Protein, Human, Recombinant (Flag) is expressed in HEK293 mammalian cells with Flag tag. The predicted molecular weight is 187.36 kDa and the accession number is NP_001726.2.
TMPY-00507	UNC5B Protein, Human, Recombinant (hFc) unc-5 homolog B (C. elegans),UNC5H2,p53RDL1	Human	HEK293 Cells
	The netrin-1 receptor, UNC-5 Homology B, or UNC5B plays vital roles in angiogenesis, inflammation, embryonic development and carcinogenesis. Overexpression of UNC5B human colon epithelial cells suppressed dextran sodium sulfate, or DSS-induced apoptosis and caspase-3 activity. Besides, is a potential anti-neoplastic target in bladder cancer progression and inflammatory arthritis. UNC5B Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular ...
TMPY-04133	UNC5B Protein, Human, Recombinant (His) UNC5H2,p53RDL1,unc-5 homolog B (C. elegans)	Human	HEK293 Cells
	The netrin-1 receptor, UNC-5 Homology B, or UNC5B plays vital roles in angiogenesis, inflammation, embryonic development and carcinogenesis. Overexpression of UNC5B human colon epithelial cells suppressed dextran sodium sulfate, or DSS-induced apoptosis and caspase-3 activity. Besides, is a potential anti-neoplastic target in bladder cancer progression and inflammatory arthritis. UNC5B Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular ...
TMPH-01709	Mucin-5B/MUC5B Protein, Human, Recombinant (His & Myc)	Human	E. coli
	Gel-forming mucin that is thought to contribute to the lubricating and viscoelastic properties of whole saliva and cervical mucus. Mucin-5B/MUC5B Protein, Human, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 18.9 kDa and the accession number is Q9HC84.
TMPY-04003	UNC5B Protein, Rat, Recombinant (hFc) unc-5 homolog B (C. elegans)	Rat	HEK293 Cells
	The netrin-1 receptor, UNC-5 Homology B, or UNC5B plays vital roles in angiogenesis, inflammation, embryonic development and carcinogenesis. Overexpression of UNC5B human colon epithelial cells suppressed dextran sodium sulfate, or DSS-induced apoptosis and caspase-3 activity. Besides, is a potential anti-neoplastic target in bladder cancer progression and inflammatory arthritis. UNC5B Protein, Rat, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular we...
TMPH-01134	Complement C8g Protein, Human, Recombinant (His) C8G,Complement component C8 gamma chain	Human	E. coli
	C8 is a constituent of the membrane attack complex. C8 binds to the C5B-7 complex, forming the C5B-8 complex. C5-B8 binds C9 and acts as a catalyst in the polymerization of C9. The gamma subunit seems to be able to bind retinol. Complement C8g Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 26.4 kDa and the accession number is P07360.
TMPJ-00585	Complement C8 gamma Protein, Human, Recombinant (His) C8 γ,Complement component C8 gamma chain,C8G,Complement comp...	Human	E. coli
	Complement component C8 is a constituent of the membrane attack complex, C8 alpha, C8 beta and C8G. C8G is a secreted protein and comsists a disulfide-linked C8 alpha-gamma heterodimer and a non-covalently associated C8 beta chain. C8 alpha and C8 beta play an important role in complement-mediated bacterial killing together.C8 is involved in the formation of Membrane Attack Complex on bacterial cell membranes. C8 binds to the C5B-7 complex, forming the C5B-8 complex. C5-B8 binds C9 and acts as a...

重组蛋白

Complement C5 Protein, Human, Recombinant (His & FLAG)

Cat.No: TMPY-05057

Species: Human

Expression System: HEK293 Cells

Complement C5 Protein, Human, Recombinant (Complement C5a)

Cat.No: TMPY-00653

Species: Human

Expression System: E. coli

Complement C5 Protein, Human, Recombinant (Flag)

Cat.No: TMPY-06814

Species: Human

Expression System: HEK293 Cells

UNC5B Protein, Human, Recombinant (hFc)

Cat.No: TMPY-00507

Species: Human

Expression System: HEK293 Cells

UNC5B Protein, Human, Recombinant (His)

Cat.No: TMPY-04133

Species: Human

Expression System: HEK293 Cells

Mucin-5B/MUC5B Protein, Human, Recombinant (His & Myc)

Cat.No: TMPH-01709

Species: Human

Expression System: E. coli

UNC5B Protein, Rat, Recombinant (hFc)

Cat.No: TMPY-04003

Species: Rat

Expression System: HEK293 Cells

Complement C8g Protein, Human, Recombinant (His)

Cat.No: TMPH-01134

Species: Human

Expression System: E. coli

Complement C8 gamma Protein, Human, Recombinant (His)

Cat.No: TMPJ-00585

Species: Human

Expression System: E. coli

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