Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T18485 |
NH2-C4-NH-Boc
N-叔丁氧羰基-1,4-丁二胺 |
Others; PROTAC Linker | Others; PROTAC |
NH2-C4-NH-Boc 是一种属于 Alkyl/ether 类的 PROTAC linker,可用于一系列 PROTAC 分子的合成。 | |||
T36841 |
IPI-9119
|
Fatty Acid Synthase | Metabolism |
IPI-9119 是一种具有口服活性、选择性和不可逆的 FASN 抑制剂 (IC50 = 0.3 nM)。 | |||
T14584 |
Biotin-PEG2-C4-alkyne
|
Others | Others |
Biotin-PEG2-C4-alkyne is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells. | |||
T18624 |
NH2-Ph-C4-acid-NH2-Me
PROTAC Linker 31 |
Others | Others |
NH2-Ph-C4-acid-NH2-Me (PROTAC Linker 31) is an alkyl chain-based compound utilized for the synthesis of PROTACs. [1] | |||
T18623 |
Boc-NH-PEG2-C2-amido-C4-acid
PROTAC Linker 30 |
Others | Others |
Boc-NH-PEG2-C2-amido-C4-acid (PROTAC Linker 30) is a polyethylene glycol (PEG)-based linker utilized for the synthesis of Proteolysis Targeting Chimeras (PROTACs)[1]. | |||
T17910 |
(S,R,S)-AHPC-PEG2-C4-Cl
E3 ligase Ligand-Linker Conjugates 10,VHL Ligand-Linker Conjugates 7,VH032-PEG2-C4-Cl |
Others | Others |
(S,R,S)-AHPC-PEG2-C4-Cl is a small molecule HaloPROTAC that incorporates the (S,R,S)-AHPC based VHL ligand and 2-unit PEG linker. (S,R,S)-AHPC-PEG2-C4-Cl is capable of inducing the degradation of GFP-HaloTag7 in cell-based assays[1]. | |||
T27601 |
IMTPPE
SID-3712502,SID 3712502,SID3712502 |
||
IMTPPE inhibits transcriptional activity and protein level of AR in C4-2 prostate cancer cells. It also inhibits AR-target gene expression. | |||
T18533 |
PEG3-C4-OBn
|
Others | Others |
PEG3-C4-OBn, a polyethylene glycol (PEG)-based PROTAC linker, is utilized in crafting the PROTAC SGK3 degrader-1, a potent SKG3 degrader leveraging PROTAC technology [1][2]. | |||
T37564 |
C4 Ceramide (d18:1/4:0)
C4 Ceramide (d18:1/4:0),Cer(d18:1/4:0) |
||
C4 Ceramide is a bioactive sphingolipid and cell-permeable analog of naturally occurring ceramides. [1] [2] [3] It inhibits IL-4 production by 16% in EL4 T cells stimulated with phorbol 12-myristate 13-acetate when used at a concentration of 10 μM. [1] C4 Ceramide is cytotoxic to SK-BR-3 and MCF-7/Adr breast cancer cells (IC50s = 15.9 and 19.9 μM, respectively). [2] C4 Ceramide also increases maturation and stability of cystic fibrosis transmembrane conductance regulator (CFTR) proteins bearing... | |||
T62031 | SARS-CoV-2 nsp13-IN-4 | ||
SARS-CoV-2 nsp13-IN -4 (C4 (d)) 是强效的、选择性的 nsp13 helicase 小分子抑制剂。SARS-CoV-2 nsp13-IN -4 抑制 nsp13 的 ssDNA+ ATPase 活性,IC50值为57 μM。SARS-CoV-2 nsp13-IN-4 显示广谱抗病毒作用。 | |||
T17906 |
Pomalidomide-amido-C4-amido-PEG2-C2-NH-Boc
E3 Ligase Ligand-Linker Conjugates 53,Cereblon Ligand-Linker Conjugates 20 |
Others | Others |
Pomalidomide-amido-C4-amido-PEG2-C2-NH-Boc is a novel synthesized conjugate compound functioning as an E3 ligase ligand-linker in PROTAC technology. This compound incorporates a Pomalidomide-derived cereblon ligand, which binds selectively to the E3 ligase cereblon, and a 2-unit PEG linker, which provides stability and flexibility to the conjugate. | |||
T37506 |
MCTR2
MCTR2 |
||
Maresin conjugates in tissue regeneration 2 (MCTR2) is a specialized pro-resolving mediator (SPM) synthesized from docosahexaenoic acid in macrophages at the site of inflammation. DHA is oxidized to maresin 1 , which is converted to MCTR1 by glutathione S-transferase Mu 4 or leukotriene C4 synthase then to MCTR2 by γ-glutamyl transferase. MCTR2 accelerates tissue regeneration in planaria (1 and 100 nM). Pretreatment with MCTR2 prior to E. coli administration reduces neutrophil infiltration, shor... | |||
T35790 |
Palmitic acid-1,2,3,4-13C4
Palmitic Acid-13C (C1, C2, C3, and C4 labeled) |
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Palmitic acid-13C (C1, C2, C3, and C4 labeled) is intended for use as an internal standard for the quantification of palmitic acid by GC- or LC-MS. Palmitic acid is a common 16-carbon saturated fat that represents 10-20% of human dietary fat intake and comprises approximately 25 and 65% of human total plasma lipids and saturated fatty acids, respectively.1,2Acylation of palmitic acid to proteins facilitates anchoring of membrane-bound proteins to the lipid bilayer and trafficking of intracellula... | |||
T37736 |
N-cis-hexadec-9Z-enoyl-L-Homoserine lactone
N-(2-oxotetrahydrofuran-3S-yl) Palmitoleyl Amide,N-cis-hexadec-9Z-enoyl-L-Homoserine lactone |
||
Quorum sensing is a regulatory process used by bacteria for controlling gene expression in response to increasing cell density.[1] This regulatory process manifests itself with a variety of phenotypes including biofilm formation and virulence factor production.[2] Coordinated gene expression is achieved by the production, release, and detection of small diffusible signal molecules called autoinducers. The N-acylated homoserine lactones (AHLs) comprise one such class of autoinducers, each of whic... | |||
T37741 |
N-hexadecanoyl-L-Homoserine lactone
C16-HSL,N-palmitoyl-L-Homoserine,N-hexadecanoyl-L-Homoserine lactone |
||
Quorum sensing is a regulatory system used by bacteria for controlling gene expression in response to increasing cell density.[1] This regulatory process manifests itself with a variety of phenotypes including biofilm formation and virulence factor production.[2] Coordinated gene expression is achieved by the production, release, and detection of small diffusible signal molecules called autoinducers. The N-acylated homoserine lactones (AHLs) comprise one such class of autoinducers, each of which... |