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Cat. No.	Product Name	Target	Signaling Pathways
T8722	iKIX1	Antifungal	Microbiology/Virology
	iKIX1 是一种 Pdr1 依赖性基因激活。它在体外和在播散性和泌尿道光滑念珠菌感染的动物模型中使耐药的光滑念珠菌对唑类抗真菌剂重新敏感。它可研究多药耐药性和光滑念珠菌感染。
T2305	Isavuconazole 艾沙康唑,BAL-4815,RO-0094815	P450; Antibiotic; Antifungal	Metabolism; Microbiology/Virology
	Isavuconazole (RO-0094815) 是一种三唑类前药，对酵母、霉菌和二型真菌具有抗真菌活性。它抑制麦角固醇生物合成，导致真菌膜结构和功能的破坏。它是 CYP3A4抑制剂。
T36434	Sordarin sodium
	Sordarin is an inhibitor of fungal protein synthesis originally isolated from S. araneosa.[1] It binds to elongation factor 2 (EF-2) in the presence of ribosomes and inhibits the uncoupled GTPase activity of equimolar mixtures of EF-2 and ribosomes from C. albicans (IC50 = 0.1 μM). Sordarin inhibits protein synthesis in cell-free lysates of C. albicans, C. glabrata, and C. neoformans (IC50s = 0.01, 0.2, and 0.06 μg/ml, respectively) but not in rabbit reticulocytes (IC50 = >100 μg/ml).[1] [2] It...
T36437	Sphinganine (d17:0) Sphinganine (d17:0)
	Sphinganine is a synthetic bioactive sphingolipid that inhibits the growth of C. glabrata and C. albicans with a minimum fungicidal concentration (MFC) value of 0.5 μg/ml for both. More commonly, sphinganine is used as an internal standard in the analysis of sphingoid compounds by chromatographic or spectrometric methods.
T35902	Milbemycin A4 oxime
	Milbemycin A4 oxime is a derivative of milbemycin A4 and a component of milbemycin oxime , compounds that both have insecticidal and nematocidal activity. Milbemycin A4 oxime (0.05 mg/kg) reduces the number of microfilariae of the heartworm D. immitis in naturally infested dogs. It inhibits the growth of clinical isolates of C. glabrata with MIC80 values ranging from 16 to greater than 32 μg/ml. Milbemycin A4 oxime (2.5 μg/ml) blocks efflux of fluconazole from a clinical isolate of C. glabrata, ...
T79384	Antifungal agent 72
	Antifungalagent 72（Compound B8）是一款高效抗真菌药物。该化合物通过抑制Pdr1-KIX相互作用（Ki：11.7μM）来干扰外排泵功能，并降低与耐药性相关的基因表达。Antifungalagent 72对抗氟康唑（Fluconazole）耐药的C. glabrata 0161菌株显示出显著的抗菌活性，其MIC值为63 ng/mL，并与氟康唑合用时表现出协同效果。此化合物可应用于C. glabrata感染的相关研究。
T60965	Anticandidal agent-1
	Anticandidal agent-1 (化合物 c2) 是有效的广谱抗念珠菌剂，可通过阻断菌丝伸长和丝化来抑制生物膜。Anticandidal agent-1 对光滑念珠菌和白念珠菌具有抗念珠菌活性，MIC50值分别为 13.51 和 8.65 μg/mL。
T36057	Diallyl Tetrasulfide ICD-1585
	Diallyl tetrasulfide is an organosulfur compound that has been found in A. sativum and has diverse biological activities, including antimicrobial, antioxidant, and anticancer properties.[1],[2],[3],[4] It is active against the bacteria S. aureus and methicillin-resistant S. aureus (MRSA; MICs = 0.5 and 2 mg/L, respectively), as well as the fungi C. albicans, C. krusei, C. glabrata, A. niger, A. flavus, and A. fumigatus (MICs = 0.5, 4, 2, 1, 2, and 4 mg/L, respectively).[1] It reduces cadmium-ind...