Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T9029 |
STING-IN-3
C-171 |
STING | Immunology/Inflammation |
STING-IN-3 (C-171) 是干扰素基因刺激物 (STING) 的抑制剂。 它与 STING 结合,抑制其棕榈酰化,并阻止 TBK1 的募集和磷酸化。 | |||
T9061 |
EN4
EN4 MYC inhibitor |
c-Myc | Cell Cycle/Checkpoint |
EN4 (EN4 MYC inhibitor) 是一种靶向 MYC 的半胱氨酸 171 (C171) 的共价配体。它抑制 MYC 转录活性,下调 MYC 靶标,并具有抗肿瘤作用。它对 c-MYC 的选择性高于 N-MYC 和 L-MYC。 | |||
T38269 | Purfalcamine | ||
Purfalcamine is an orally active, selective Plasmodium falciparum calcium-dependent protein kinase 1 (PfCDPK1) inhibitor with an IC50 of 17 nM and an EC50 of 230 nM. Purfalcamine has antimalarial activity and causes malaria parasites developmental arrest at the schizont stage[1][2]. Purfalcamine has low activity against Toxoplasma gondii calcium-dependent protein kinase 3 (TgCDPK3)[1]. Purfalcamine (225, 450 nM) has no effect on the parasitemia in the first 32 hours. After about 40 hours, paras... |