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Search Results for " bestatin "

21

抑制剂 & 化合物

3

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T18612	Bestatin-amido-Me PROTAC IAP binding moiety 1	Others	Others
	Bestatin-amido-Me, a derivative of Bestatin, acts as an IAP ligand and interacts with ABL inhibitor through a linker to produce SNIPER[1].
T38470	Obestatin (human)
	Obestatin (human) 是一种由 preproghrelin 经过剪切形成的G蛋白欧联实体39的内源性配体，可以剂量依赖的方式抑制进食，可用于研究肥胖。
TP2279L	Obestatin (rat) acetate	GHSR	GPCR/G Protein
	Obestatin (rat) acetate 是 G 蛋白偶联受体 39 (GPR39) 的内源性配体。它具有抗炎、抗心肌梗塞和抗氧化特性。它抑制食物摄入，抑制空肠收缩，并减少体重增加。
T25573	Ketomethylenebestatin
	Ketomethylenebestatin is a carba-analog of bestatin，the aminopeptidase (AP) inhibitor. Ketomethylenebestatin is 10 fold less effective as an inhibitor of aminopeptidases than bestatin.
T29436	4-Hydroxybestatin
	4-Hydroxybestatin is a major active metabolite of bestatin.
T71626	Epibestatin Hydrochloride
	Epibestatin Hydrochloride is a stabilizer of 14-3-3 PPIs, as well as a diastereoepimer of aminopeptidase inhibitor bestatin.
T81626	Obestatin(11-23)mouse, rat
	Obestatin(11-23)mouse, rat 是多肽，涉及能量平衡调节，抑制摄食。该化合物能使啮齿类动物食量减少、体重降低、及空肠收缩。
T35787	Obestatin (human) (trifluoroacetate salt)
	Obestatin is a 23 amino acid peptide hormone with a conserved C-terminal glycine residue and amidation site that is formed by cleavage of the ghrelin and obestatin prepropeptide.1It binds to the orphan receptor GPR39 (Kd= 1 nM) and stimulates cAMP production in CHO and HEK293 cells overexpressing human GPR39. Obestatin inhibits contraction of isolated mouse jejunum muscle strips induced by ghrelin .In vivo, obestatin (12.5-1,000 nmol/kg) suppresses food intake in a time- and dose-dependent manne...
T75901	Obestatin(rat) TFA
	Obestatin(rat) TFA 是一个包含23个氨基酸的肽，由Ghrelin基因编码。该化合物能够抑制食欲和空肠收缩，并能减缓体重增加。同时，Obestatin(rat) TFA 作为G 蛋白偶联受体 39 (GPR39) 的内源性配体，发挥抗炎、抗心肌梗塞和抗氧化功能。
TP2279	Obestatin(rat) Obestatin (rat)	Others	Others
	Endogenous peptide that suppresses food intake and body weight-gain
T81625	Obestatin(human) TFA
	Obestatin(human) TFA, 同源于与ghrelin相同的前体多肽，是一种内源性肽。该化合物抑制大鼠食欲并降低体重增加。
T18684	SNIPER(ABL)-013	Others	Others
	SNIPER(ABL)-013, conjugating GNF5 (ABL inhibitor) to Bestatin (IAP ligand) with a linker, induces the reduction of BCR-ABL protein with a DC50 of 20 μM[1].
T18650	Ch55-O-C3-NH2 RAR ligand 1	Others	Others
	Ch55-O-C3-NH2, also known as RAR ligand 1, is a ligand derived from the Ch55 compound that specifically targets RAR. Through a linker, Ch55-O-C3-NH2 interacts with cIAP1 ligand Bestatin to form SNIPER[1].
T17940	Estrone-N-O-C1-amido ERα ligand 1	Others	Others
	Estrone-N-O-C1-amido (ERα ligand 1) is an estrogen ligand derived from Estrone that specifically binds to estrogen receptor α (ERα). Through a linker, Estrone-N-O-C1-amido (ERα ligand 1) forms a complex with the cIAP1 ligand Bestatin, leading to the creation of SNIPER[1].
T18687	SNIPER(ABL)-020	Others	Others
	SNIPER(ABL)-020 is a chemical compound consisting of Dasatinib, an ABL inhibitor, and Bestatin, an IAP ligand, conjugated with a linker. This compound effectively reduces the BCR-ABL protein[1].
T17545	Biotin-BS	Others	Others
	Biotin-BS is a chemical compound composed of two distinct ligands: methyl-bestatin (MeBS) for cIAP1 and biotin. These ligands are interconnected through linkers. MeBS serves as a ligand specifically for the cellular inhibitor of apoptosis protein 1 (cIAP1) ubiquitin ligase[1].
T18693	SNIPER(ABL)-049	Others	Others
	SNIPER(ABL)-049, conjugating Imatinib (ABL inhibitor) to Bestatin (IAP ligand) with a linker, induces the reduction of BCR-ABL protein with a DC50 of 100 μM[1].
T18691	SNIPER(ABL)-044	Others	Others
	SNIPER(ABL)-044, conjugating HG-7-85-01 (ABL inhibitor) to Bestatin (IAP ligand) with a linker, induces the reduction of BCR-ABL protein with a DC50 of 10 μM[1].
T14288	Androstanolone acetate	Others	Others
	Androstanolone acetate is a compound that functions as an androgen ligand, specifically targeting the androgen receptor (AR). It binds to the cIAP1 ligand Bestatin through a linker, resulting in the formation of PROTACs[1].
T17706	BzNH-BS	Others	Others
	BzNH-BS is a chemical compound comprising two distinct ligands: methyl-bestatin (MeBS) for cIAP1 and benzoyl-amide. The ligands are interconnected through linkers. MeBS functions as a ligand for cIAP1, a ubiquitin ligase involved in cellular inhibition of apoptosis processes [1].
T17733	ATRA-hydroxyimino CRABP-II ligand 1	Others	Others
	ATRA-hydroxyimino, also known as CRABP-II ligand 1, is a chemical compound derived from Retinoic acid (ATRA). This compound binds to the cIAP1 ligand, specifically Bestatin, through a linker, resulting in the formation of a complex called SNIPER. The purpose of this complex is to degrade CRABP-II within IMR-32 cells[1].

化合物

Bestatin-amido-Me

Cat.No: T18612

Synonym: PROTAC IAP binding moiety 1

Target: Others

Obestatin (human)

Cat.No: T38470

Obestatin (rat) acetate

Cat.No: TP2279L

Target: GHSR

Ketomethylenebestatin

Cat.No: T25573

4-Hydroxybestatin

Cat.No: T29436

Epibestatin Hydrochloride

Cat.No: T71626

Obestatin(11-23)mouse, rat

Cat.No: T81626

Obestatin (human) (trifluoroacetate salt)

Cat.No: T35787

Obestatin(rat) TFA

Cat.No: T75901

Cat.No: TP2279

Synonym: Obestatin (rat)

Target: Others

Obestatin(human) TFA

Cat.No: T81625

SNIPER(ABL)-013

Cat.No: T18684

Target: Others

Cat.No: T18650

Synonym: RAR ligand 1

Target: Others

Estrone-N-O-C1-amido

Cat.No: T17940

Synonym: ERα ligand 1

Target: Others

SNIPER(ABL)-020

Cat.No: T18687

Target: Others

Cat.No: T17545

Target: Others

SNIPER(ABL)-049

Cat.No: T18693

Target: Others

SNIPER(ABL)-044

Cat.No: T18691

Target: Others

Androstanolone acetate

Cat.No: T14288

Target: Others

Cat.No: T17706

Target: Others

ATRA-hydroxyimino

Cat.No: T17733

Synonym: CRABP-II ligand 1

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T1257	Bestatin Ubenimex,乌苯美司	Others; Aminopeptidase; Antibacterial; Antibiotic; LTR	Immunology/Inflammation; Metabolism; Microbiology/Virology; Others
	Bestatin (Ubenimex) 是 CD13 (Aminopeptidase N)/APN 和 leukotriene A4 hydrolase 抑制剂，可用于癌症研究。
T3529	Bestatin hydrochloride 盐酸乌苯美司,Ubenimex hydrochloride,苯丁抑制素	Integrin; Aminopeptidase; Antibacterial; Antibiotic	Cytoskeletal Signaling; Metabolism; Microbiology/Virology
	Bestatin hydrochloride (Ubenimex hydrochloride) 是CD13(Aminopeptidase N)/APN 和leukotriene A4 hydrolase 抑制剂，可研究癌症。
T62258	Bestatin trifluoroacetate
	Bestatin trifluoroacetate (Ubenimex trifluoroacetate) 是一种 CD13 (Aminopeptidase N)/APN 和 leukotriene A4 hydrolase 抑制剂，经常用于研究癌症。

天然产物

Cat.No: T1257

Synonym: Ubenimex,乌苯美司

Target: Others, Aminopeptidase, Antibacterial, Antibiotic, LTR

Bestatin hydrochloride

Cat.No: T3529

Synonym: 盐酸乌苯美司,Ubenimex hydrochloride,苯丁抑制素

Target: Integrin, Aminopeptidase, Antibacterial, Antibiotic

Bestatin trifluoroacetate

Cat.No: T62258

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