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20

抑制剂 & 化合物

8

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
TP2372	Beefy meaty peptide
	Beefy meaty peptide is a bioactive chemical.
T131610	Bebeerine
	Bebeerine 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T131610。
TP1497L	Mast Cell Degranulating Peptide HR-2 acetate Mast Cell Degranulating Peptide HR-2 acetate(80388-04-1 free base)	Others	Others
	Mast Cell Degranulating Peptide HR-2 acetate(80388-04-1 free base) 来自大黄蜂 Vespa orientalis 的肥大细胞脱粒肽，其生物学效应类似于来自蜂毒的肥大细胞脱粒肽。
TP1299	Melittin 蜂毒素,蜂毒肽	Phospholipase	Metabolism
	Melittin 是 PLA2激活剂，能够刺激低分子量 PLA2的活性，而不刺激高分子量 PLA2的活性。
TP1299L	Melittin TFA(20449-79-0(free base))	Phospholipase	Metabolism
	Melittin TFA(20449-79-0(free base)) 是一种含有 26 个氨基酸残基的小蛋白质，是蜂毒的主要毒性成分。它是一种 PLA2 活化剂，可刺激低分子量 PLA2 的活性，而不会增加高分子量 PLA2 的活性。
TP1223L	Apamin acetate Apamine acetate,Apamin acetate(24345-16-2 Free base)	Potassium Channel	Membrane transporter/Ion channel
	Apamin acetate (Apamine acetate) 是一种具有选择性的 Ca2+ 激活的 K+ (SK) 通道的阻断剂，是在蜂毒素中发现的一种 18 个氨基酸的肽类神经毒素。Apamin acetate 可增强皮质神经元撕裂损伤后的神经突生长和再生。Apamin acetate 具有抗炎和抗纤维化的作用。
TP1568	Mast cell degranulating peptide (28-49)
	Mast cell degranulating peptide (28-49) is a bee venom depolarizer that can improve the cGMP content of cerebellum tablets in mice.
TP1222	Apamin TFA (24345-16-2 free base) Apamin TFA,Apamine TFA
	Apamin TFA (Apamine TFA) is a toxin found in bee venom. It is a potent blocker of small conductance Ca2+-activated K+ (SK, KCa2) channels that is more effective at SK2 than SK1 and SK3.
T32072	Hexyl decanoate Decanoic acid hexyl ester
	Hexyl decanoate, the first trail pheromone compound identified in a stingless bee, Trigona recursa. Hexyl decanoate is dominant component of gland secretions.
T31831	Fluvalinate Kartan,Fluvalinate II,Fluvalinate I,Mavrik,Klartan,Apistan
	Fluvalinate is a synthetic chemical compound and can be commonly used to control varroa mites in honey bee colonies.
T23847	Cajucarinolide
	Cajucarinolide is a clerodane diterpene. It inhibits bee venom phospholipase A2 in vitro. Cajucarinolide possesses anti-inflammatory activity.
TP1497	Mast Cell Degranulating Peptide HR-2
	Peptide from giant hornet Vespa orientalis that has biological effects similar to mast cell degranulating peptide from bee venom.
TP1223	Apamin Apamine
	Apamin (Apamine) is an 18 amino acid peptide neurotoxin found in apitoxin (bee venom), is known as a specifically selective blocker of Ca2+-activated K+ (SK) channels and exhibits anti-inflammatory and anti-fibrotic activity. Apamin is a bee venom compone
TP2114	Tertiapin-Q
	A high affinity blocker for inward-rectifier K+ channels, this compound is a stable derivative of the bee venom toxin tertiapin. Binds to ROMK1 (Kir1.1) and GIRK1/4 (Kir3.1/3.4) channels with high affinity (Ki values are 1.3 and 13.3 nM respectively) and
T75746	Apamin TFA
	Apamin TFA (Apamine TFA) 是在蜂毒素中发现的一种 18 个氨基酸的肽类神经毒素，是一种 Ca2+激活的 K+(SK) 通道的特异性和选择性的阻断剂，具有抗炎和抗纤维化的作用。
T37123	1,2-Dioctanoyl PC
	Phosphatidylcholine (PC) species are a common class of phospholipids that comprise the mammalian cell membrane. 1,2-Dioctanoyl PC is a synthetic analog of natural phosphatidylcholine species containing saturated C8:O fatty acids in the sn-1 and sn-2 positions of the glycerol backbone. It exhibits a critical micelle concentration (CMC) value of 0.25 mM at 27°C. 1,2-Dioctanoyl PC serves as an efficient substrate for phospholipase D (PLD) as well as sPLA2 isozymes from bovine pancreas and bee venom...
T37244	Palmitoyl thio-PC
	Thioester analogs of glycerophospholipids, in combination with Ellman's reagent, are convenient colorimetric substrates for the measurement of phospholipase (PL) activity. Palmitoyl thio-PC is a chromogenic PLA2 substrate that contains a palmitoyl thioester at the sn-2 position of the glycerol backbone. Hydrolysis of the thioester by PLA2 yields a free thiol that reacts readily with DTNB (Ellman's reagent) giving a bright yellow product with an absorbance maximum at 412 nm. Palmitoyl thio-PC has...
T76468	Cecropin A (1-7)-Melittin A (2-9)
	Cecropin A (1-7)-Melittin A (2-9) 为一种具抗菌效能的肽，对广谱革兰氏阳性及革兰氏阴性需氧菌显示出显著的抗菌活性，同时展现出抗疟能力，而无蜂毒肽所致的不良溶血现象。
T83750	Melittin (C-Term Cysteine labeled) TFA Mel-Cys
	Melittin (C-term cysteine labeled)是一种衍生自具有细胞毒性的蜂毒肽melittin的衍生物，其在C-末端具有一个半胱氨酸残基。它能够在内体和细胞外pH条件下引发人类红细胞的溶血作用（分别在pH 5.5和7.4时的EC50s为5和6 µM）。Melittin (C-term cysteine labeled)已被用于合成膜溶解性聚合物，这些聚合物已用于体外和体内质粒递送的polyplexes的生成。
T35419	τ-Fluvalinate
	τ-Fluvalinate is a pyrethroid acaricide.1It induces tail currents in Western honeybee (A. mellifera) voltage-gated sodium channels (AmNav1) expressed inXenopusoocytes (EC50= 60 nM). It also induces tail currents in honeybee parasitic Varroa mite (V. destructor) Nav1 channels (VdNav1) expressed inXenopusoocytes (EC50= 160 nM) with a faster tail current decay than that of AmNav1 channels. Topical application of τ-fluvalinate (2 μl) in combination with coumaphos , atrazine , 2,4-DMPF, chlorpyrifos ...

化合物

Beefy meaty peptide

Cat.No: TP2372

Cat.No: T131610

Mast Cell Degranulating Peptide HR-2 acetate

Cat.No: TP1497L

Synonym: Mast Cell Degranulating Peptide HR-2 acetate(80388-04-1 free base)

Target: Others

Cat.No: TP1299

Synonym: 蜂毒素,蜂毒肽

Target: Phospholipase

Melittin TFA(20449-79-0(free base))

Cat.No: TP1299L

Target: Phospholipase

Cat.No: TP1223L

Synonym: Apamine acetate,Apamin acetate(24345-16-2 Free base)

Target: Potassium Channel

Mast cell degranulating peptide (28-49)

Cat.No: TP1568

Apamin TFA (24345-16-2 free base)

Cat.No: TP1222

Synonym: Apamin TFA,Apamine TFA

Hexyl decanoate

Cat.No: T32072

Synonym: Decanoic acid hexyl ester

Cat.No: T31831

Synonym: Kartan,Fluvalinate II,Fluvalinate I,Mavrik,Klartan,Apistan

Cat.No: T23847

Mast Cell Degranulating Peptide HR-2

Cat.No: TP1497

Cat.No: TP1223

Synonym: Apamine

Cat.No: TP2114

Cat.No: T75746

1,2-Dioctanoyl PC

Cat.No: T37123

Palmitoyl thio-PC

Cat.No: T37244

Cecropin A (1-7)-Melittin A (2-9)

Cat.No: T76468

Melittin (C-Term Cysteine labeled) TFA

Cat.No: T83750

Synonym: Mel-Cys

Cat.No: T35419

Cat. No.	Product Name	Target	Signaling Pathways
T3250	Royal Jelly acid 10-羟基-2-癸烯酸(10-HAD),蜂王浆酸,王浆酸,10-Hydroxy-trans-2-decenoic acid,10-Hydroxy-2-decenoic acid,10H2DA,10-Hydroxy-2-decylenic acid,Queen Bee Acid,(E)-10-Hydroxy-2-decenoic acid	VEGFR; Endogenous Metabolite	Angiogenesis; Metabolism; Tyrosine Kinase/Adaptors
	Royal Jelly acid (Queen Bee Acid) 是一种蜂王浆中的主要脂肪酸，可促进神经元的生长和保护，减少焦虑。
T3S0895	Spirostan-3-ol 剑麻皂苷元,Sarsaponin	Others	Others
	Spirostan-3-ol (Sarsaponin) 是 Sarsasapogenin 的立体异构体，是从植物材料中分离出来的类固醇糖苷，具有潜在的通过细胞凋亡的抗肿瘤活性。它可驱赶蜜蜂。
TP2223	Beesioside Q	Others	Others
	Beesioside Q 是从铁破锣 Beesia calthaefolia (Maxim.) Ulbr 的根茎中提取出来的天然产物。
TN3501	beta-Costic acid	Others	Others
	The use of costic acid and other components from the plant Dittrichia viscosa (Greek: aconiza) and related species for the preparation of acaricidal products used against the acari Varroa destructor as parasite of the honey bee.
TN2682	2-2'-(Hydroxytetracosanoylamino)-octadecane-1,3,4-triol tetraacetate	Others	Others
	(2S,3S,4R,2'R )-2-(2'-Hydroxytetracosanoylamino) octadecane-1,3,4-triol at concentration of 100 ug/mL shows selectively inhibitory activity against phospholipase A 2 (PLA 2) secreted from Crotalus adamenteus venom, but inactive against PLA 2 of bee venom
TN4505	Masticadienolic acid	Others	Others
	Masticadienolic acid is a specific competitive inhibitor of secreted phospholipase A2, it not only protects the active site histidine from alkylation but also inhibits the action of secreted from pancreas, synovial fluid, and bee venom. Masticadienolic ac
T80343	MCF
	MCF为源自蜂毒的抗菌肽，对E.coli W 160-37、S.aureus 8530及B.subtilis展现出抗菌活性，其最小抑菌浓度(MIC)值分别为E.coli W 160-37为35-45 μg/ml，S.aureus 8530为25-35 μg/ml，及B.subtilis为15-25 μg/ml。
T36828	9(Z)-Tricosene
	(9Z)-Tricosene is a pheromone released by insects, including D. melanogaster, M. domestica (house fly), and A. mellifera L. (honey bee). In Drosophila, it induces aggregation behavior and is an oviposition guidance cue for females. Due to its aggregation-inducing activity, it is used as a bait pesticide to attract insects to traps. The mechanism of action in Drosophila is the activation of antennal basiconic Or7a receptors. It is also highly produced by honey bees during the waggle dance, which ...

天然产物

Royal Jelly acid

Cat.No: T3250

Synonym: 10-羟基-2-癸烯酸(10-HAD),蜂王浆酸,王浆酸,10-Hydroxy-trans-2-decenoic acid,10-Hydroxy-2-decenoic acid,10H2DA,10-Hydroxy-2-decylenic acid,Queen Bee Acid,(E)-10-Hydroxy-2-decenoic acid

Target: VEGFR, Endogenous Metabolite

Cat.No: T3S0895

Synonym: 剑麻皂苷元,Sarsaponin

Target: Others

Cat.No: TP2223

Target: Others

beta-Costic acid

Cat.No: TN3501

Target: Others

2-2'-(Hydroxytetracosanoylamino)-octadecane-1,3,4-triol tetraacetate

Cat.No: TN2682

Target: Others

Masticadienolic acid

Cat.No: TN4505

Target: Others

Cat.No: T80343

Cat.No: T36828

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