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Cat. No. Product Name Target Signaling Pathways
T0718 Brivudine

Bromovinyldeoxyuridine,BVDU,溴夫定

Others; HSV Microbiology/Virology; Others
Brivudine (BVDU) 是胸苷类似物,有抗病毒活性,用于早期急性带状疱疹的研究。
T67796 C-BVDU

C-BVDU 是一种非常有效的选择性抗疱疹病毒化合物。
T80655 BVDU 5′-Triphosphate

BVdUTP,(E)-5-(2-Bromovinyl)-dUTP

DNA/RNA Synthesis Cell Cycle/Checkpoint; DNA Damage/DNA Repair
BVDU 5′-Triphosphate 是带有 5′-Triphosphate 标记、针对 DNA 聚合酶的抗病毒药物。它对水痘-带状疱疹病毒(VZV)和单纯疱疹病毒 1 型(HSV-1)具有高度选择性,这种选择性归因于病毒编码的胸苷激酶对其进行特异性磷酸化的能力。
T68656 Brivudine monophosphate

Brivudine monophosphate is a phosphate ester of Brivudine. Brivudine, also known as bromovinyl-deoxyuridine, is a uridine derivative and nucleoside analog with pro-apoptotic and chemosensitizing properties. In vitro, bromovinyl-deoxyuridine (BVDU) has been shown to downregulate the multifunctional DNA repair enzyme APEX nuclease 1, resulting in the inhibition of DNA repair and the induction of apoptosis. In addition, this agent may inhibit the expression of STAT3 (signal transducer and activator...
T35439 (E)-5-(2-Bromovinyl)uracil

(E)-5-(2-Bromovinyl)uracil (BVU) is a pyrimidine base and an inactive metabolite of the antiviral agents sorivudine and (E)-5-(2-bromovinyl)-2'-deoxyuridine (BVDU) that may be regenerated to BVDU in vivo. BVU irreversibly inactivates dihydropyrimidine dehydrogenase (DPD) in an NADPH-dependent manner. It enhances the efficacy of the chemotherapeutic agent and DPD substrate 5-fluorouracil in a P388 murine leukemia model when administered at a dose of 200 μmol/kg, increasing survival time.

化合物

Brivudine
Cat.No: T0718
Synonym: Bromovinyldeoxyuridine,BVDU,溴夫定
Target: Others, HSV
C-BVDU
Cat.No: T67796
Synonym:
Target:
BVDU 5′-Triphosphate
Cat.No: T80655
Synonym: BVdUTP,(E)-5-(2-Bromovinyl)-dUTP
Target: DNA/RNA Synthesis
Brivudine monophosphate
Cat.No: T68656
Synonym:
Target:
(E)-5-(2-Bromovinyl)uracil
Cat.No: T35439
Synonym:
Target:
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