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Cat. No.	Product Name	Target	Signaling Pathways
T10601	BRCA1-IN-2	Others	Others
	BRCA1-IN-2 是一种可穿过细胞膜的 BRCA1 蛋白-蛋白相互作用（PPI）抑制剂，具有抗肿瘤活性，通过破坏 BRCA1 (BRCT)2 与蛋白质的相互作用来发挥作用。
T10600	BRCA1-IN-1	Others	Others
	BRCA1-IN-1 is a novel small-molecule-like inhibitor of BRCA1 (IC50: 0.53 μM; Ki: 0.71 μM).
T8873	Bractoppin	Others; DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Others
	Bractoppin 是一种BRCA1 (t)BRCT domain 识别磷酸肽的选择性抑制剂，IC50为 74 nM。它优先抑制 BRCA1 -tBRCT 依赖的 DNA 损伤。它减少 BRCA1 对 DNA 断裂片段的招募，进而抑制损伤诱导的 G2 期阻滞和重组酶 RAD51 的组装。
T16807	Rucaparib monocamsylate 瑞卡帕布樟脑磺酸盐,Rucaparib Camsylate	PARP	Chromatin/Epigenetic; DNA Damage/DNA Repair
	Rucaparib monocamsylate (Rucaparib Camsylate) 是一种口服有效的 PARP 蛋白抑制剂，对 PARP-1 的Ki 为 1.4 nM。它是六磷酸己糖脱氢酶 (H6PD) 抑制剂，有用于去势抵抗性前列腺癌 (CRPC) 的研究潜力。
T6253	Talazoparib LT-673,BMN-673,他拉唑帕利	PARP	Chromatin/Epigenetic; DNA Damage/DNA Repair
	Talazoparib (LT-673) 是一种具有口服活性的 PARP 1/2抑制剂，IC50为0.58 nM，具有抗肿瘤活性。它抑制 PARP1 和 PARP2 酶活性的 Ki 值分别为 1.2 nM 和 0.87 nM。
T4463	Rucaparib AG-14447,PF-01367338,瑞卡帕布,AG014699	PARP	Chromatin/Epigenetic; DNA Damage/DNA Repair
	Rucaparib (PF-01367338) 是一种口服有效的 PARP 蛋白抑制剂，对 PARP-1 的 Ki 为 1.4 nM。它是六磷酸己糖脱氢酶 (H6PD) 抑制剂，有用于去势抵抗性前列腺癌 (CRPC) 的研究潜力。
T6127	Rucaparib Phosphate AG-014699 phosphate,PF-01367338,芦卡帕利,AG-014699,瑞卡帕布磷酸盐,PF-01367338 phosphate	PARP	Chromatin/Epigenetic; DNA Damage/DNA Repair
	Rucaparib Phosphate (PF-01367338 phosphate) 是一种口服有效的PARP 蛋白抑制剂，对 PARP-1 的Ki 为 1.4 nM。它是六磷酸己糖脱氢酶 (H6PD) 抑制剂，有用于去势抵抗性前列腺癌 (CRPC) 的研究潜力。
T10936	D-I03 DI03	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	D-I03 是一种选择性的RAD52 抑制剂，Kd 为 25.8 µM。D-I03 抑制 RAD52 依赖性单链退火 (SSA) 和 D 环形成，IC50 分别为 5 µM 和 8 µM。D-I03 抑制 BRCA1 和 BRCA2 缺陷细胞的生长，并抑制顺铂诱导的 RAD52 病灶形成，但对 RAD51 无影响。
T73343	BAP1-IN-1
	BAP1-IN-1 是一种 BRCA1 相关蛋白 1 (BAP1) 催化活性抑制剂，其IC50为 0.1-1 μM。
T71757	SC-10914
	SC10914 is a highly potent PARP inhibitor (PARP1 IC50 = 7.87 nM) with potent anti-proliferative activity against human BRCA deficient tumor cells (MDA-MB-436, BRCA1 deficient, IC50 = 4.03 nM, Capan-1 BRCA2 deficient, IC50 = 11.66 nM) and PTEN deficient tumor cells (HGC-27,PTEN deficient, IC50 = 0.35 μM). SC10914 showed potent anti-tumor activity in BRCA1/2 mutant tumor models and better pharmacokinetics profile has the potential to be selected as the clinical candidate for the treatment of treat...
TP2299	tumor protein p53 binding protein fragment [Homo sapiens]/[Mus musculus]	Others	Others
	Tumor protein p53 binding protein (53BP1) has been identified in a yeast two-hybrid screen as a protein that interacts with the central DNA–binding domain of p532. Similar to breast cancer susceptibility gene 13, 4 (BRCA1; 53BP1 enhances p53-dependent tra
T79593	PARP1-IN-14	PARP	Chromatin/Epigenetic; DNA Damage/DNA Repair
	PARP1-IN-14 (compound 19k) 为高效PARP1抑制剂，IC50值为0.6 ± 0.1 nM。此化合物对MDA-MB-436 (BRCA1−/−) 及Capan-1 (BRCA2−/−) 细胞线展现出显著的抗增殖效应，IC50低至0.3 nM以下。
T79405	PARP1-IN-15	PARP	Chromatin/Epigenetic; DNA Damage/DNA Repair
	PARP1-IN-15（Compound 6）是一款针对PARP1的抑制剂，能够抑制坦聚合酶(TNKS)并促进DNA双链断裂损伤。该化合物在诱导肿瘤细胞凋亡(apoptosis)方面具有显著作用，且在三阴性乳腺癌(TNBC)细胞及来源于TNBC患者的类器官中显示出抗癌活性，适用于探究BRCA1突变状态下的TNBC研究。
T69596	SK-575
	SK-575 is a Highly Potent and Efficacious Proteolysis-Targeting Chimera Degrader of PARP1 for Treating Cancers. SK-575 potently inhibits the growth of cancer cells bearing BRCA1/2 mutations and induces potent and specific degradation of PARP1 in various human cancer cells even at low picomolar concentrations. SK-575 achieves durable tumor growth inhibition in mice when used as a single agent or in combination with cytotoxic agents, such as temozolomide and cisplatin.
T83855	TG2-179-1
	TG2-179-1是BRCA1相关蛋白1（BAP1）的抑制剂。它在25 µM至1.5 mM的浓度范围内，通过无细胞测定法抑制BAP1的去泛素化活性。TG2-179-1对八种结肠癌细胞系表现出细胞毒性（IC50s = 4.48-7.52 µM）。在体内，TG2-179-1（10和30 mg/kg）能够减少HCT116结肠癌小鼠异种移植模型中的肿瘤体积。
T36701	Phosphoramide mustard (cyclohexanamine)
	Phosphoramide mustard cyclohexanamine is the major metabolite for Cyclophosphamide , with anticancer activitiy. Phosphoramide mustard cyclohexanamine induces DNA adduct formation in ovarian granulosa cells, induces DNA damage and elicits the ovarian DNA repair response[1][2]. Phosphoramide mustard cyclohexanamine causes cytotoxicity through forming cross-linked DNA adducts which inhibit DNA strand separation during replication[1].Phosphoramide mustard cyclohexanamine destroys rapidly dividing ce...

化合物

Cat.No: T10601

Target: Others

Cat.No: T10600

Target: Others

Cat.No: T8873

Target: Others, DNA/RNA Synthesis

Rucaparib monocamsylate

Cat.No: T16807

Synonym: 瑞卡帕布樟脑磺酸盐,Rucaparib Camsylate

Target: PARP

Cat.No: T6253

Synonym: LT-673,BMN-673,他拉唑帕利

Target: PARP

Cat.No: T4463

Synonym: AG-14447,PF-01367338,瑞卡帕布,AG014699

Target: PARP

Rucaparib Phosphate

Cat.No: T6127

Synonym: AG-014699 phosphate,PF-01367338,芦卡帕利,AG-014699,瑞卡帕布磷酸盐,PF-01367338 phosphate

Target: PARP

Cat.No: T10936

Synonym: DI03

Target: DNA/RNA Synthesis

Cat.No: T73343

Cat.No: T71757

tumor protein p53 binding protein fragment [Homo sapiens]/[Mus musculus]

Cat.No: TP2299

Target: Others

Cat.No: T79593

Target: PARP

Cat.No: T79405

Target: PARP

Cat.No: T69596

Cat.No: T83855

Phosphoramide mustard (cyclohexanamine)

Cat.No: T36701

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