Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T15441 |
GSK8573
|
Epigenetic Reader Domain | Chromatin/Epigenetic |
GSK8573 是 GSK2801 的非活性对照化合物。它与BRD9具有结合活性,Kd 值为 1.04 μM。 | |||
T2436 |
GSK2801
|
Apoptosis; Epigenetic Reader Domain | Apoptosis; Chromatin/Epigenetic |
GSK2801 是一种有口服活性的和细胞活性的乙酰赖氨酸竞争性BAZ2A 和BAZ2B 溴结构域选择性抑制剂,Kd 值分别为 136 nM 和 257 nM。 | |||
T14512 |
BAZ2-ICR
|
Epigenetic Reader Domain | Chromatin/Epigenetic |
BAZ2-ICR is an epigenetic chemical probe and it also is a potent, selective, cell active and orally active BAZ2A/B bromodomains inhibitor with IC50s of 130 nM and 180 nM, and Kds of 109 nM and 170 nM, respectively. BAZ2-ICR shows 10-15-fold selectivity for binding BAZ2A/B over CECR2 and >100-fold selectivity over all other bromodomains. |