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Cat. No. | Product Name | Target | Signaling Pathways |
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T10453 | BACE1-IN-5 | Beta Amyloid; BACE | Neuroscience |
BACE1-IN-5 (Compound 15) 是一种 BACE1抑制剂,IC50为 9.1 nM。BACE1-IN-5还可抑制细胞 Aβ,IC50为 0.82 nM。并且,BACE1-IN-5 具有改善 hERG 抑制和 P-gp 外排的药物化学作用。 | |||
T35975 |
6,9-Dichloro-1,2,3,4-tetrahydroacridine
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6,9-Dichloro-1,2,3,4-tetrahydroacridine is a synthetic intermediate in the synthesis of tacrine-based acetylcholinesterase (AChE) inhibitors.1It is also an intermediate in the synthesis of multifunctional tacrine hybrids that possess radical scavenging, amyloid-β aggregation inhibitory, and/or β-secretase 1 (BACE1) inhibitory activities in addition to their activity as AChE inhibitors.2,3 1.Recanatini, M., Cavalli, A., Belluti, F., et al.SAR of 9-amino-1,2,3,4-tetrahydroacridine-based acetylchol... |
Cat. No. | Product Name | Target | Signaling Pathways |
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T4115 |
Auraptene
橙皮油内酯,7-geranyloxycoumarin,橙皮油素 |
MMP; BACE | Neuroscience; Proteases/Proteasome |
Auraptene 是一种丰富的天然香叶氧基香豆素。它能够抑制基质金属蛋白酶 2 以及关键炎症因子,包括 IL-6,IL-8 和趋化因子 (C-C 基序) 配体-5 (CCL5)的分泌。 |