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Cat. No.	Product Name	Target	Signaling Pathways
T10415	Autotaxin-IN-3	PDE	Metabolism
	Autotaxin-IN-3 是 Autotaxin 的抑制剂(IC50 = 2.4 nM)，Autotaxin 负责增加腹水和血浆中的溶血磷脂酸。
T22086	HA 155 Autotaxin Inhibitor IV	PDE	Metabolism
	HA 155 (Autotaxin Inhibitor IV) 是一种基于硼酸的化合物，通过选择性结合其催化苏氨酸来抑制 ATX，IC50 为 5.7 nM。
T10416	Autotaxin-IN-4	PDE	Metabolism
	Autotaxin-IN-4 is an Autotaxin inhibitor. It has the potential to treat idiopathic pulmonary fibrosis.
T10418	Autotaxin modulator 1	PDE	Metabolism
	Autotaxin modulator 1 is a new modulator of Autotaxin.
T10417	Autotaxin-IN-5	PDE	Metabolism
	Autotaxin-IN-5 is an Autotaxin inhibitor. It has the potential to treat idiopathic pulmonary fibrosis.
T14352	Autotaxin-IN-1	PDE	Metabolism
	Autotaxin-IN-1 is a potent autotaxin inhibitor, which has favorable potency (IC50=2.2 nM), PK properties, and a robust PK/PD relationship and it is used in treatment of osteoarthritis pain[1].
T72837	Autotaxin-IN-6
	Autotaxin-IN-6 (compound 23)，一种ATX (自分泌运动分子)抑制剂，具有30 nM的IC50值，能够减少细胞迁移，适用于抗癌研究。
T11533	Z-HA155 CS-963	PDE	Metabolism
	Z-HA155 (CS-963) 是一种高效的 ATX 选择性抑制剂，其 IC50=5.7 nM。
T63190	Cudetaxestat BLD-0409	PDE	Metabolism
	Cudetaxestat (BLD-0409) 是口服具有活力的autotaxin 的有效抑制剂。
T2646	HA130	PDE	Metabolism
	HA130 是选择性 autotaxin 抑制剂，IC50=28 nM。
T10545	BIO-32546	PDE	Metabolism
	BIO-32546 (S-isomer) 是一种高效的 autotaxin (ATX) 的调节剂，IC50 值为 1 nM。
T4041	Ziritaxestat GLPG1690	PDE	Metabolism
	Ziritaxestat (GLPG1690) 是一种创新的 autotaxin (ATX)抑制剂，其 IC50=131 nM，Ki=15 nM。
T38759	ONO-8430506	PDE	Metabolism
	ONO-8430506 是一种可口服的、具有有效性的 autotaxin (ATX)/ENPP2 抑制剂（ IC90 ：100 nM），能够抑制小鼠血浆中 ATX 活性。
T3631	PF-8380	PDE	Metabolism
	PF8380 是有效的autotaxin 抑制剂，在体外酶实验和人类全血细胞实验中的IC50分别为 2.8 nM 和 101 nM。
T31101	CRT0273750 CRT 0273750,CRT-0273750	PDE	Metabolism
	CRT0273750 是一种 ATX 抑制剂的先导化合物，可调节血浆中 LPA 水平，用于 ATX/LPA 依赖性癌症模型。
T10409	ATX inhibitor 5	PDE	Metabolism
	ATX inhibitor 5 是一种有效且具有口服活性的 autotaxin (ATX) 抑制剂（IC50 ： 15.3 nM），可降低 CCl4 诱导的肝纤维化水平，具有抗肝纤维化作用，。
T12372	PAT-505	EGFR	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	PAT-505 是一种可口服且具有选择性和高效性的自体表皮生长因子抑制剂（在 Hep3B 细胞中的 IC50 为 2 nM，在人体血液中的 IC50 为 9.7 nM，在小鼠血浆中的 IC50 为 62 nM）。
T16434	PAT-048	PDE	Metabolism
	PAT-048 is an effective and selective autotaxin inhibitor. PAT-048 reduces dermal fibrosis in vivo. PAT-048 also inhibits IL-6 mRNA expression but displays no effect on autotaxin protein and pulmonary lysophosphatidic acid (LPA) production in the lung fibrosis model. PAT-048 has an IC50 and IC90 of 20 nM and 200 nM for autotaxin in mouse plasma.
T23293	S32826 disodium S 32826	Others	Others
	autotaxin inhibitor
T38488	S32826
	S32826 is a highly potent inhibitor of autotaxin, exhibiting an IC50 value of 8.8 nM. It displays comparable inhibitory properties towards various autotaxin isoforms, including α, β, and γ. Furthermore, S32826 effectively inhibits the release of LPA from adipocytes.
T63564	ATX inhibitor 22
	ATX inhibitor 22 是 ATX (autotaxin) 的新型抑制剂 (IC50: 218.9 μM)，对 LPAR1 缺乏抑制活性。
T28301	PAT-494 PAT 494,PAT494
	PAT-494 is an inhibitor of type II Autotaxin.
T36138	BMP-22
	BMP-22 is an inhibitor of autotaxin (IC50 = 170 nM). It is selective for autotaxin over the phosphodiesterases NPP6 and NPP7 at 10 μM. BMP-22 (0.1-1,000 nM) inhibits autotaxin-mediated production of lysophosphatidic acid (LPA) from lysophosphatidylcholine in vitro in a concentration-dependent manner. It inhibits LPC-dependent MM1 cell invasion of a human umbilical vein endothelial cell (HUVEC) monolayer. BMP-22 (0.5 mg/kg per day) decreases the number of lung metastatic foci in a B16/F10 syngene...
T28299	PAT-078 PAT078,PAT 078
	PAT-078 is an inhibitor of type II autotaxin.
T39136	ATX inhibitor 7
	ATX inhibitor 7 is a autotaxin inhibitor and shows good oral exposure.
T63612	ATX inhibitor 8
	ATX inhibitor 8 是自分泌运动因子 Autotaxin (ATX) 抑制剂。
T63575	PF-8380 hydrochloride
	PF-8380 hydrochloride 是一种有效的autotaxin 抑制剂，体外酶实验和人类全血细胞实验中，IC50分别为 2.8 nM 和 101 nM。
T70275	PAT-347
	PAT-347 is a potent Autotaxin Inhibitor. Autotaxin (ATX) is a secreted enzyme responsible for the hydrolysis of lysophosphatidylcholine (LPC) to the bioactive lysophosphatidic acid (LPA) and choline. The ATX-LPA signaling pathway is implicated in cell survival, migration, and proliferation; thus, the inhibition of ATX is a recognized therapeutic target for a number of diseases including fibrotic diseases, cancer, and inflammation, among others.
T14560	BI-2545	Others	Others
	BI-2545 is an autotaxin (ATX) inhibitor that significantly reduces LPA. For human ATX and rat ATX, the IC50s values are 2.2 nM and 3.4 nM , respectively.
T28300	PAT-347 sodium PAT-347,PAT347,PAT 347
	PAT-347 is a potent inhibitor of Autotaxin (ATX), a secreted enzyme responsible for the hydrolysis of lysophosphatidylcholine (LPC) to the bioactive lysophosphatidic acid (LPA) and choline.
T81804	MEY-003
	MEY-003是针对Autotaxin(ATX)的抑制剂，具有对hATX-β和hATX-ɣ的EC50值分别为460 nM和1.09 μM（LPC18:1分析条件下）。作为一种非竞争性抑制剂，其Ki值为432 nM。该化合物主要应用于ATX相关疾病的研究领域。
T69647	UCM-05194
	UCM-05194 is a potent Agonist of the Type 1 Lysophosphatidic Acid Receptor (LPA1). UCM-05194 Shows Efficacy in Neuropathic Pain Amelioration. UCM-05194 stands out as the most potent and selective LPA1 receptor agonist described so far (Emax = 118%, EC50 = 0.24 μM, KD = 19.6 nM; inactive at autotaxin and LPA2-6 receptors).
T64141	ATX inhibitor 11
	ATX inhibitor 11 是 ATX (autotaxin) 的有效抑制剂 (IC50: 2.7 nM)。ATX inhibitor 11 能够缓解小鼠纤维化模型中纤维化组织的严重程度，有效减少纤维化生物标志物 α-SMA 的沉积。ATX inhibitor 11 能够用于研究肺纤维化。
T61612	ATX inhibitor 15
	ATX inhibitor 15 (compound 30) is an indole-based carbamate derivative with a strong inhibitory effect on autotaxin (ATX), demonstrated by an IC50 of 2.17 nM. Additionally, ATX inhibitor 15 effectively inhibits ATX activity in vivo and suppresses the expression of pro-fibrotic genes. Furthermore, ATX inhibitor 15 exhibits protective effects in lung fibrosis induced by Bleomycin in mice [1].
T38000	Lysosphingomyelin (d18:1)
	Sphingomyelins are complex membrane lipids composed of phosphorylcholine, sphingosine, and an acylated group, such as a fatty acid. Lysosphingomyelin is a naturally-occurring lipid which is produced by the removal of the acylated group of sphingomyelin by a deacylase. Lysosphingomyelin may, in turn, serve as a substrate for autotaxin, which removes choline to produce sphingosine-1-phosphate. The receptors and signaling pathways that are activated by lyso-sphingosine are diverse and vary between ...
T63325	ATX inhibitor 9
	ATX inhibitor 9 是增稠的杂芳基衍生物化合物，也是 ATX 的有效抑制剂。其中 Autotaxin (ATX)，也称为 ENPP2，是一种主要在肺癌细胞、支气管上皮细胞和肺泡巨噬细胞中高度表达的分泌酶。ATX inhibitor 9 对癌症或纤维退行性疾病具有研究潜力。

化合物

Autotaxin-IN-3

Cat.No: T10415

Target: PDE

Cat.No: T22086

Synonym: Autotaxin Inhibitor IV

Target: PDE

Autotaxin-IN-4

Cat.No: T10416

Target: PDE

Autotaxin modulator 1

Cat.No: T10418

Target: PDE

Autotaxin-IN-5

Cat.No: T10417

Target: PDE

Autotaxin-IN-1

Cat.No: T14352

Target: PDE

Autotaxin-IN-6

Cat.No: T72837

Cat.No: T11533

Synonym: CS-963

Target: PDE

Cat.No: T63190

Synonym: BLD-0409

Target: PDE

Cat.No: T2646

Target: PDE

Cat.No: T10545

Target: PDE

Cat.No: T4041

Synonym: GLPG1690

Target: PDE

Cat.No: T38759

Target: PDE

Cat.No: T3631

Target: PDE

Cat.No: T31101

Synonym: CRT 0273750,CRT-0273750

Target: PDE

ATX inhibitor 5

Cat.No: T10409

Target: PDE

Cat.No: T12372

Target: EGFR

Cat.No: T16434

Target: PDE

S32826 disodium

Cat.No: T23293

Synonym: S 32826

Target: Others

Cat.No: T38488

ATX inhibitor 22

Cat.No: T63564

Cat.No: T28301

Synonym: PAT 494,PAT494

Cat.No: T36138

Cat.No: T28299

Synonym: PAT078,PAT 078

ATX inhibitor 7

Cat.No: T39136

ATX inhibitor 8

Cat.No: T63612

PF-8380 hydrochloride

Cat.No: T63575

Cat.No: T70275

Cat.No: T14560

Target: Others

Cat.No: T28300

Synonym: PAT-347,PAT347,PAT 347

Cat.No: T81804

Cat.No: T69647

ATX inhibitor 11

Cat.No: T64141

ATX inhibitor 15

Cat.No: T61612

Lysosphingomyelin (d18:1)

Cat.No: T38000

ATX inhibitor 9

Cat.No: T63325

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