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Search Results for " arg1 "

Targets Recommended: Bradykinin Receptor

14

抑制剂 & 化合物

4

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
TP1181	Bradykinin (2-9) Des-Arg1-bradykinin	Bradykinin Receptor	GPCR/G Protein
	Bradykinin (2-9) (Des-Arg1-bradykinin)，是Bradykinin的一种氨基端截短肽类代谢物，通过Aminopeptidase P的切割作用形成。
TP1931L1	[D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P acetate [D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P acetate(96736-12-8 free base)	cholecystokinin	GPCR/G Protein
	[D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P acetate ([D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P acetate (96736-12-8 free base)) 是广谱神经肽反向激动剂和拮抗剂。 ghrelin 受体的强效完全反向激动剂(EC50 = 5.2 nM)；减少组成型生长素释放肽受体信号传导。它也是速激肽、缓激肽、CCK 和铃蟾肽受体的拮抗剂。在体外诱导细胞凋亡并抑制癌细胞生长。
T39932	ARG1-IN-1 ARG1-IN-1
	ARG1-IN-1 is a human arginase 1 inhibitor with an IC 50 of 29 nM.
TP1931	[D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P
	Broad spectrum neuropeptide inverse agonist and antagonist. Potent full inverse agonist for the ghrelin receptor (EC50 = 5.2 nM); diminishes constitutive ghrelin receptor signaling. Also antagonist at tachykinin, bradykinin, CCK and bombesin receptors. In
T78656	ARG1-IN-1 hydrochloride	Arginase	Immunology/Inflammation
	ARG1-IN-1 (example 1) hydrochloride为一种针对人类精氨酸酶1的抑制剂，具有29 nM的IC50值。
T76446	(D-Arg1,D-Pro2,D-Phe7,D-His9)-Substance P
	(D-Arg1,D-Pro2,D-Phe7,D-His9)-Substance P 是一种选择性的 NK1receptor 拮抗剂。
T76445	(D-Arg1,D-Pro2,D-Trp7,9,L-Leu11)-Substance P
	(D-Arg1,D-Pro2,D-Trp7,9,L-Leu11)-Substance P 是神经肽 Substance P 的拮抗剂。
T83548	(D-Arg1,D-Pro2,D-Trp7,9,L-Leu11)-Substance P acetate
	'(D-Arg1,D-Pro2,D-Trp7,9,L-Leu11)-Substance P (acetate)' 是一种对 Substance P 及 Bombesin 担任拮抗作用的化合物，能针对眼部三叉神经反向刺激引起的炎症反应产生效果。
T83195	Acetyl-(D-Phe2,Lys15,Arg16,Leu27)-VIP (1-7)-GRF (8-27)
	Acetyl-(D-Phe2,Lys15,Arg16,Leu27)-VIP (1-7)-GRF (8-27)，是一种血管活性肠肽，起到VIP1受体拮抗剂的作用。
T75896	[Arg14,Lys15]Nociceptin TFA
	[Arg14,Lys15]Nociceptin TFA 是一种高效、选择性的 NOP (ORL1; OP4)受体激动剂，EC50为 1 nM。[Arg14,Lys15]Nociceptin TFA 对阿片受体具有较高的选择性，对 NOP、μ、δ 和 κ 受体的 IC50值分别为 0.32、280、>10000 和 1500 nM。
TP1986	[Arg14,Lys15]Nociceptin
	Highly potent and selective NOP receptor agonist (EC50 = 1 nM). Displays > 875-fold selectivity over opioid receptors (IC50 values are 0.32, 280, > 10000 and 1500 for NOP, μ, δ and κ receptors respectively). Longer lasting and 30-fold more potent than noc
T83690	[Leu144, Arg147]-PLP (139-151) TFA [Leu144, Arg147] Proteolipid Peptide (139-151),H-His-Ser-Leu-Gly-Lys-Leu-Leu-Gly-Arg-Pro-Asp-Lys-Phe-OH
	[Leu144,Arg147]-PLP (139-151)是髓鞘脂蛋白(PLP)的一种突变肽段，包含位于144和147位置的色氨酸到亮氨酸以及组氨酸到精氨酸的替换。使用[Leu144, Arg147]-PLP (139-151)（50 µg）乳化于完全弗氏佐剂(CFA)免疫后，能增加小鼠脾脏中的IL-4水平。它在体外抑制Th1细胞激活，但在体内不抑制，其中它诱导调节性T细胞的产生。用[Leu144, Arg147]-PLP (139-151)预免疫可以延迟由脑炎肽PLP (178-191)、髓磷脂少突细胞蛋白(MOG) (92-106)或髓鞘基础蛋白(MBP)在小鼠中诱导的实验性自身免疫性脑炎(EAE)的发病。
T83500	[Des-Arg10]-HOE I40
	[Des-Arg10]-HOE 140 是一种有效的 B1 缓激肽受体拮抗剂，具备生物活性。
T83779	EP4 Antagonist 14 Prostaglandin E2 Receptor 4 Antagonist 14,PGE2 Receptor 4 Antagonist 14
	EP4 antagonist 14是一种前列腺素E2（PGE2）受体亚型EP4的拮抗剂，其在使用表达人源受体的HEK293细胞的报告基因测定中的IC50值为1.1 nM。它还能抑制PGE2诱导的同种细胞中的β-阿雷斯汀招募（IC50 = 0.9 nM）。EP4 antagonist 14（10 µM）能减少RAW 264.7巨噬细胞中PGE2诱导的mRNA表达，这些mRNA编码Il-4、巨噬细胞甘露糖受体1（Mrc1）、几丁质酶样蛋白3（Chil3）、趋化因子（C-X-C）基序配体1（Cxcl1）、表达在髓样细胞上的触发受体2（Trem2）和精氨酸酶-1（Arg1）。在体内，EP4 antagonist 14（每天30 mg/kg），结合抗PD-1抗体，能够在CT26小鼠结肠癌模型中抑制肿瘤生长并增加CD8+ T细胞对肿瘤的浸润。

化合物

Bradykinin (2-9)

Cat.No: TP1181

Synonym: Des-Arg1-bradykinin

Target: Bradykinin Receptor

[D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P acetate

Cat.No: TP1931L1

Synonym: [D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P acetate(96736-12-8 free base)

Target: cholecystokinin

Cat.No: T39932

Synonym: ARG1-IN-1

[D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P

Cat.No: TP1931

ARG1-IN-1 hydrochloride

Cat.No: T78656

Target: Arginase

(D-Arg1,D-Pro2,D-Phe7,D-His9)-Substance P

Cat.No: T76446

(D-Arg1,D-Pro2,D-Trp7,9,L-Leu11)-Substance P

Cat.No: T76445

(D-Arg1,D-Pro2,D-Trp7,9,L-Leu11)-Substance P acetate

Cat.No: T83548

Acetyl-(D-Phe2,Lys15,Arg16,Leu27)-VIP (1-7)-GRF (8-27)

Cat.No: T83195

[Arg14,Lys15]Nociceptin TFA

Cat.No: T75896

[Arg14,Lys15]Nociceptin

Cat.No: TP1986

[Leu144, Arg147]-PLP (139-151) TFA

Cat.No: T83690

Synonym: [Leu144, Arg147] Proteolipid Peptide (139-151),H-His-Ser-Leu-Gly-Lys-Leu-Leu-Gly-Arg-Pro-Asp-Lys-Phe-OH

[Des-Arg10]-HOE I40

Cat.No: T83500

EP4 Antagonist 14

Cat.No: T83779

Synonym: Prostaglandin E2 Receptor 4 Antagonist 14,PGE2 Receptor 4 Antagonist 14

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-02168	Arginase 1/ARG1 Protein, Human, Recombinant (His) arginase 1,ARG1	Human	HEK293 Cells
	Arginase 1/ARG1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 36.2 kDa and the accession number is P05089-1.
TMPY-04685	Arginase 1/ARG1 Protein, Human, Recombinant (His & MYC) arginase 1,ARG1	Human	HEK293 Cells
	Arginase 1/ARG1 Protein, Human, Recombinant (His & MYC) is expressed in HEK293 mammalian cells with His and MYC tag. The predicted molecular weight is 36.7 kDa and the accession number is P05089-1.
TMPH-02524	Arginase-1/ARG1 Protein, Mouse, Recombinant (His) Arginase-1,Type I arginase,Liver-...	Mouse	P. pastoris (Yeast)
	Key element of the urea cycle converting L-arginine to urea and L-ornithine, which is further metabolized into metabolites proline and polyamides that drive collagen synthesis and bioenergetic pathways critical for cell proliferation, respectively; the urea cycle takes place primarily in the liver and, to a lesser extent, in the kidneys.; Functions in L-arginine homeostasis in nonhepatic tissues characterized by the competition between nitric oxide synthase (NOS) and arginase for the available i...
TMPH-02525	Arginase-1/ARG1 Protein, Mouse, Recombinant (His & SUMO) Liver-type arginase,Type I arginase,Ar...	Mouse	E. coli
	Arginase-1/ARG1 Protein, Mouse, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 50.8 kDa and the accession number is Q61176.

重组蛋白

Arginase 1/ARG1 Protein, Human, Recombinant (His)

Cat.No: TMPY-02168

Species: Human

Expression System: HEK293 Cells

Arginase 1/ARG1 Protein, Human, Recombinant (His & MYC)

Cat.No: TMPY-04685

Species: Human

Expression System: HEK293 Cells

Arginase-1/ARG1 Protein, Mouse, Recombinant (His)

Cat.No: TMPH-02524

Species: Mouse

Expression System: P. pastoris (Yeast)

Arginase-1/ARG1 Protein, Mouse, Recombinant (His & SUMO)

Cat.No: TMPH-02525

Species: Mouse

Expression System: E. coli

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