Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T2923 |
Apremilast
阿普斯特,CC-10004,阿普司特 |
Apoptosis; TNF; PDE | Apoptosis; Metabolism |
Apremilast (CC-10004) 是一种口服有效的磷酸二酯酶 4 抑制剂,IC50为 74 nM。它抑制脂多糖释放TNF-α,IC50为 104 nM。 | |||
T12612 |
(R)-Apremilast
R-阿普斯特,(R)-CC-10004 |
Others | Others |
(R)-Apremilast ((R)-CC-10004) 是一种 Apremilast 的异构体。 | |||
T21043 |
Apremilast, (+/-)-
Apremilast (+/-)-, |
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Apremilast, (+/-)-, is a small molecule inhibitor of phosphodiesterase 4 (PDE4) with oral activity. It is used to treat psoriatic arthritis. | |||
T10350 |
Apremilast-d5
Apremilast D5,CC-10004 D5 |
TNF; PDE | Apoptosis; Metabolism |
Apremilast D5 (CC-10004 D5) is a deuterium-labeled Apremilast. Apremilast is an orally available inhibitor of PDE-4 (IC50: 74 nM). Apremilast inhibits TNF-α release by lipopolysaccharide (IC50: 104 nM). | |||
T35929 |
O-Demethyl Apremilast
|
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O-Demethyl apremilast is an active metabolite of the phosphodiesterase 4 (PDE4) inhibitor apremilast .1It inhibits the activity of PDE4 isolated from U937 cells and LPS-induced TNF-α production in isolated human peripheral blood mononuclear cells (PBMCs; IC50s = 8.3 and 5.6 μM, respectively). O-Demethyl apremilast is also an oxidative degradation product of apremilast.2,3 1.Hoffmann, M., Kumar, G., Schafer, P., et al.Disposition, metabolism and mass balance of [14C]apremilast following oral admi... | |||
T12656 |
(Rac)-Apremilast D5
(Rac)-CC-10004 D5 |
Others | Others |
(Rac)-Apremilast D5 is a deuterium-labeled version of the enantiomer (R)-Apremilast, also known as (R)-CC-10004, which itself is one specific form of Apremilast. |