Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TP1260 |
[Pyr1]-Apelin-13
[pGlu1]-Apelin-13,人牛吡啶APELIN-13 |
Apelin receptor | GPCR/G Protein |
[Pyr1]-Apelin-13 ([pGlu1]-Apelin-13) 是一种高效的、内源性 apelin 受体选择性激动剂。 | |||
T7656 |
Apelin-13
|
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Apelin-13 是存在于中枢和外周神经系统由13个氨基酸组成的多肽序列,是 G 蛋白偶联受体angiotensin II protein J (APJ) 的内源性配体,对 APJ 的 EC50 值为 0.37 nM。Apelin-13 具有扩张血管和降压活性,可用于研究 2 型糖尿病综合征。 | |||
T7847 |
Apelin-13 triTFA(217082-58-1(free base))
|
Others | Others |
Apelin-13 triTFA(217082-58-1(free base)) 是 APJ 受体的内源性配体,可激活该 G 蛋白偶联受体,EC50 值为 0.37 nM。 | |||
T35374 |
(Ala13)-Apelin-13
(Ala13)-Apelin-13 |
Others | Others |
(Ala13)-Apelin-13 是一种有效的 APJ 受体拮抗剂,可以防止 apelin 诱导的胃张力和运动性降低。 | |||
T35374L |
(Ala13)-Apelin-13 acetate
|
Apelin receptor | GPCR/G Protein |
(Ala13)-Apelin-13 acetate,一种 APJ 拮抗剂,可调节CRF 诱导的增强的结肠运动、内脏敏感性和肠屏障。 | |||
TP1424 |
Apelin-13 TFA (217082-58-1 free base)
Apelin-13 TFA |
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Apelin-13 is an endogenous ligand of APJ receptor, and the EC 50 value of activated G protein coupled receptor is 0.37 nM. | |||
T78109 |
(Ala13)-Apelin-13 TFA
|
||
'(Ala13)-Apelin-13 TFA' 为高效的APJ受体拮抗剂,能够通过迷走神经胆碱能通路抑制胃动力。 | |||
T4390 |
ML221
|
Apelin receptor; Arrestin | GPCR/G Protein |
ML221 是apelin (APJ)拮抗剂,能够抑制 apelin-13 介导的 APJ 的活化,在 cAMP 试验和 β-arrestin 实验中,IC50值分别为 0.70 μM 和 1.75 μM,EC80值均为 10 nM。 | |||
TP2001 |
MM 54
|
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Potent apelin receptor antagonist (Ki = 82 nM; IC50 = 93 nM). Antagonizes the inhibitory affect of [Pyr1]-Apelin-13 on forskolin-induced cAMP accumulation in CHO-K1-APJ cells. Recuces tumor expansion and lengthens survival time in a mouse xenograft model | |||
T39813 |
APJ receptor agonist 1
|
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APJ receptor agonist 1, a potent biphenyl acid derivative, acts as an agonist (EC50 of 0.093 nM and 0.12 nM for human and rat APJ receptors, respectively) for the APJ receptor (APJ-R). It exhibits significant in vitro potency towards apelin-13, the endogenous peptidic ligand for the APJ receptor. APJ receptor agonist 1 holds promise for heart failure research. |