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Cat. No. | Product Name | Target | Signaling Pathways |
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T1501 |
Rifabutin
LM-427,Ansamycin,利福布汀,利福布丁 |
HSP; DNA/RNA Synthesis; Antibacterial; Antibiotic | Cell Cycle/Checkpoint; Cytoskeletal Signaling; DNA Damage/DNA Repair; Metabolism; Microbiology/Virology |
Rifabutin (LM-427) 是半合成的安莎霉素抗生素,抑制 DNA 依赖性 RNA 聚合酶,有抗分枝杆菌作用。 | |||
T6558 |
KW-2478
KW2478 |
HSP | Cytoskeletal Signaling; Metabolism |
KW-2478 是一种非安沙霉素Hsp90α抑制剂,IC50值为 3.8 nM。它对多种人类血液肿瘤细胞具有抗肿瘤活性。 | |||
T24895 |
Tolypomycin Y
NSC177383,NSC 177383,B-2847-Y,NSC-177383 |
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Tolypomycin Y is a naturally occurring ansamycin antibiotic. | |||
T36385 |
Ansatrienin A
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Ansatrienin A is an ansamycin antibiotic and antifungal agent first isolated from S. collinus and S. rishiriensis. In fetal rat long bones, it is an inhibitor of parathyroid hormone-induced calcium release (IC50 = 64 nM), which is a measure of bone resorption, and pp60c-srcM kinase (IC50 = 100 nM). It also inhibits TNF-α-induced expression of intercellular adhesion molecule-1 (ICAM-1; IC50 = 570 nM). Early in vitro studies showed that ansatrienin A potentiates the chemotherapeutic action of 5-fl... | |||
T36650 |
Ansatrienin B
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Ansatrienin B is an ansamycin antibiotic and antifungal agent first isolated from S. collinus and S. rishiriensis., In fetal rat long bones, it is an inhibitor of parathyroid hormone-induced calcium release (IC50 = 21 nM), which is a measure of bone resorption, and pp60c-src kinase (IC50 = 50 nM). It is an inhibitor of translation at the protein synthesis stage by specific inhibition of L-leucine incorporation (IC50 = 58 nM in A549 cells). It also inhibits TNF-α-induced expression of intercellul... |
Cat. No. | Product Name | Target | Signaling Pathways |
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T21351 |
Maytansine
NSC-153858,NSC153858,Maitansina,NSC 153858,Maitansine,美坦新 |
Microtubule Associated; Antibiotic | Cytoskeletal Signaling; Microbiology/Virology |
Maytansine (NSC-153858) 是从变叶美登木中分离的一种高效微管靶向天然产物,可诱导有丝分裂阻滞并在亚纳摩尔浓度杀死肿瘤细胞。 | |||
T40883 |
N-Demethylansamitocin P-3
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N-Demethylansamitocin P-3, a derivative of Ansamitocin, an antitumor ansamycin antibiotic, can be synthesized through the action of Streptomyces minutiscleroticus IFO 13361. |