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Search Results for " angii "

Targets Recommended: RAAS

抑制剂 & 化合物

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T4431	Olodanrigan PD-126055,EMA401	RAAS	Endocrinology/Hormones
	Olodanrigan (EMA401) 是具有口服活性、高选择性及外周受限的血管紧张素 Ⅱ 类型 2 受体(AT2R)拮抗剂。它的缓解疼痛的机制可能是：抑制增强的 AngII/AT2R 诱导的 p38 和 p42/p44 MAPK 激活，进而阻碍 DRG 神经元的过度兴奋性及 DRG 神经元的萌发。它可用于研究神经性疼痛。
T70932	L6H9
	L6H9 is a novel inhibitor of myeloid differentiation factor 2 (MD2), suppressing HG-induced expression of ACE and AT1 receptor and Angiotensin II (AngII) production in renal NRK‐52E cells, resulting in the decrease in fibrosis markers such as TGF-β and collagen IV.
T7616	A 779	RAAS	Endocrinology/Hormones
	A 779 是一种 G 蛋白偶联受体 Mas 的有效拮抗剂，Mas 受体是Ang1-7 receptor，与传统的AngII 不同。
T81154	SIRT1 activator 1	Sirtuin	Chromatin/Epigenetic; DNA Damage/DNA Repair
	SIRT1 activator1(compound 3)，作为海洋化合物xyloallenoide a的衍生物，最初从红树林真菌Xylaria sp中分离获得。该化合物在斑马鱼模型中展现了促进血管生成的活性，并且能够通过提升SIRT1的表达水平以及调节AMPK/Akt信号通路，来防护人类内皮祖细胞(hEPC)免受血管老化的影响。
T80509	PKC 20-28,myristoylated Myristoylated protein kinase C inhibitor 20-28	PKC	Chromatin/Epigenetic; Cytoskeletal Signaling
	PKC20-28,myristoylated（Myristoylated protein kinase C inhibitor 20-28）为具细胞渗透性之PKC抑制剂，可抑制AngII所诱导之IKca电流激活，用途涵盖癌症与心血管疾病研究。

化合物

Olodanrigan

Cat.No: T4431

Synonym: PD-126055,EMA401

PKC 20-28,myristoylated

Cat.No: T80509

Synonym: Myristoylated protein kinase C inhibitor 20-28

Target: PKC

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-02232	Angiotensinogen Protein, Mouse, Recombinant (His) AngI,Serpina8,angiotensinogen (serpin peptidase inhibitor, c...	Mouse	HEK293 Cells
	Angiotensinogen Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 50.8 kDa and the accession number is P11859.
TMPY-02574	Chymase 1 Protein, Human, Recombinant (His) MCT1,chymase 1, mast cell,chymase,CYH	Human	Baculovirus Insect Cells
	The STR polymorphism in the CMA1 gene is associated with asthma and that this association is even stronger with atopic asthma. CMA1 and IL-4 in atopic asthma and for IL-4 in atopy in general. The local angiotensin II system (LAS) has numerous functions, including the regulation of growth and differentiation in the gastrointestinal tract. Angiotensin II (AngII) may be generated by angiotensin-I-converting enzyme (ACE) or mast cell chymase (CMA1) and plays an important role in inflammatory process...