Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T1496 |
Amiodarone hydrochloride
盐酸胺碘酮,Amiodar,Amiodarone HCl,Nexterone |
Potassium Channel; Adrenergic Receptor; Autophagy | Autophagy; GPCR/G Protein; Membrane transporter/Ion channel; Neuroscience |
Amiodarone hydrochloride (Amiodarone HCl) 是一种抗心绞痛和 III 类抗心律失常药物,通过抑制钾通道和电压门控钠通道来增加心室和心房肌肉作用的持续时间,可导致心率和血管阻力降低。它通过成纤维细胞中的 ERK1/2和 p38 MAPK 信号传导诱导细胞增殖和肌成纤维细胞分化,可研究室上性和室性心律失常。 | |||
T20659 |
Desethylamiodarone
N-Deethylamiodarone,DAMI,LB-33020,LB 33020,N-Monodesethylamiodarone,LB33020 |
||
Diethylamiodarone is the main metabolite of amiodarone in vivo. | |||
T21370 |
Amiodarone
Nexterone,胺碘酮,Amiodarona,Cordarone,Aratac,Amiodaronum |
||
Amiodarone is categorized as a class III antiarrhythmic agent and prolongs phase 3 of the cardiac action potential. It also has numerous other effects, including actions that are similar to those of antiarrhythmic classes Ia, II, and IV. Amiodarone chemic | |||
T80650 | Di-N-desethyl amiodarone hydrochloride | Autophagy | Autophagy |
Di-N-desethyl Amiodarone hydrochloride为Amiodarone的代谢产物,作为一种强效的呼吸链抑制剂。该 Amiodarone作为抗心律失常剂,其机制涉及抑制ATP敏感性钾通道。 | |||
T25301 |
Deiodoamiodarone
Amiodarone hydrochloride impurity A,Dideiodo Amiodarone |
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Deiodoamiodarone is an intermediate of amiodarone. Amiodarone is an α/β-adrenergic receptor antagonist and coronary vasodilator. | |||
T11002 |
Desethylamiodarone hydrochloride
N-desethylamiodarone hydrochloride,LB 33020 hydrochloride |
Others | Others |
Desethylamiodarone hydrochloride (N-desethylamiodarone hydrochloride) is formed by the CYP3A isozyme. Amiodarone is an antiarrhythmic drug that inhibits ATP-sensitive potassium channels with an IC50 of 19.1 μM. It is the main active metabolite of amiodaro |