36
2
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T10415 |
Autotaxin-IN-3
|
PDE | Metabolism |
Autotaxin-IN-3 是 Autotaxin 的抑制剂(IC50 = 2.4 nM),Autotaxin 负责增加腹水和血浆中的溶血磷脂酸。 | |||
T22086 |
HA 155
Autotaxin Inhibitor IV |
PDE | Metabolism |
HA 155 (Autotaxin Inhibitor IV) 是一种基于硼酸的化合物,通过选择性结合其催化苏氨酸来抑制 ATX,IC50 为 5.7 nM。 | |||
T10418 | Autotaxin modulator 1 | PDE | Metabolism |
Autotaxin modulator 1 is a new modulator of Autotaxin. | |||
T10416 |
Autotaxin-IN-4
|
PDE | Metabolism |
Autotaxin-IN-4 is an Autotaxin inhibitor. It has the potential to treat idiopathic pulmonary fibrosis. | |||
T10417 |
Autotaxin-IN-5
|
PDE | Metabolism |
Autotaxin-IN-5 is an Autotaxin inhibitor. It has the potential to treat idiopathic pulmonary fibrosis. | |||
T14352 |
Autotaxin-IN-1
|
PDE | Metabolism |
Autotaxin-IN-1 is a potent autotaxin inhibitor, which has favorable potency (IC50=2.2 nM), PK properties, and a robust PK/PD relationship and it is used in treatment of osteoarthritis pain[1]. | |||
T72837 | Autotaxin-IN-6 | ||
Autotaxin-IN-6 (compound 23),一种ATX (自分泌运动分子)抑制剂,具有30 nM的IC50值,能够减少细胞迁移,适用于抗癌研究。 | |||
T11533 |
Z-HA155
CS-963 |
PDE | Metabolism |
Z-HA155 (CS-963) 是一种高效的 ATX 选择性抑制剂,其 IC50=5.7 nM。 | |||
T2646 |
HA130
|
PDE | Metabolism |
HA130 是选择性 autotaxin 抑制剂,IC50=28 nM。 | |||
T63190 |
Cudetaxestat
BLD-0409 |
PDE | Metabolism |
Cudetaxestat (BLD-0409) 是口服具有活力的autotaxin 的有效抑制剂。 | |||
T4041 |
Ziritaxestat
GLPG1690 |
PDE | Metabolism |
Ziritaxestat (GLPG1690) 是一种创新的 autotaxin (ATX)抑制剂,其 IC50=131 nM,Ki=15 nM。 | |||
T10545 |
BIO-32546
|
PDE | Metabolism |
BIO-32546 (S-isomer) 是一种高效的 autotaxin (ATX) 的调节剂,IC50 值为 1 nM。 | |||
T3631 |
PF-8380
|
PDE | Metabolism |
PF8380 是有效的autotaxin 抑制剂,在体外酶实验和人类全血细胞实验中的IC50分别为 2.8 nM 和 101 nM。 | |||
T38759 |
ONO-8430506
|
PDE | Metabolism |
ONO-8430506 是一种可口服的、具有有效性的 autotaxin (ATX)/ENPP2 抑制剂( IC90 :100 nM),能够抑制小鼠血浆中 ATX 活性。 | |||
T31101 |
CRT0273750
CRT 0273750,CRT-0273750 |
PDE | Metabolism |
CRT0273750 是一种 ATX 抑制剂的先导化合物,可调节血浆中 LPA 水平,用于 ATX/LPA 依赖性癌症模型。 | |||
T10409 |
ATX inhibitor 5
|
PDE | Metabolism |
ATX inhibitor 5 是一种有效且具有口服活性的 autotaxin (ATX) 抑制剂(IC50 : 15.3 nM),可降低 CCl4 诱导的肝纤维化水平,具有抗肝纤维化作用,。 | |||
T23293 |
S32826 disodium
S 32826 |
Others | Others |
autotaxin inhibitor | |||
T38488 |
S32826
|
||
S32826 is a highly potent inhibitor of autotaxin, exhibiting an IC50 value of 8.8 nM. It displays comparable inhibitory properties towards various autotaxin isoforms, including α, β, and γ. Furthermore, S32826 effectively inhibits the release of LPA from adipocytes. | |||
T16434 |
PAT-048
|
PDE | Metabolism |
PAT-048 is an effective and selective autotaxin inhibitor. PAT-048 reduces dermal fibrosis in vivo. PAT-048 also inhibits IL-6 mRNA expression but displays no effect on autotaxin protein and pulmonary lysophosphatidic acid (LPA) production in the lung fibrosis model. PAT-048 has an IC50 and IC90 of 20 nM and 200 nM for autotaxin in mouse plasma. | |||
T36138 |
BMP-22
|
||
BMP-22 is an inhibitor of autotaxin (IC50 = 170 nM). It is selective for autotaxin over the phosphodiesterases NPP6 and NPP7 at 10 μM. BMP-22 (0.1-1,000 nM) inhibits autotaxin-mediated production of lysophosphatidic acid (LPA) from lysophosphatidylcholine in vitro in a concentration-dependent manner. It inhibits LPC-dependent MM1 cell invasion of a human umbilical vein endothelial cell (HUVEC) monolayer. BMP-22 (0.5 mg/kg per day) decreases the number of lung metastatic foci in a B16/F10 syngene... | |||
T28299 |
PAT-078
PAT078,PAT 078 |
||
PAT-078 is an inhibitor of type II autotaxin. | |||
T28301 |
PAT-494
PAT 494,PAT494 |
||
PAT-494 is an inhibitor of type II Autotaxin. | |||
T39136 |
ATX inhibitor 7
|
||
ATX inhibitor 7 is a autotaxin inhibitor and shows good oral exposure. | |||
T63564 | ATX inhibitor 22 | ||
ATX inhibitor 22 是 ATX (autotaxin) 的新型抑制剂 (IC50: 218.9 μM),对 LPAR1 缺乏抑制活性。 | |||
T63612 | ATX inhibitor 8 | ||
ATX inhibitor 8 是自分泌运动因子 Autotaxin (ATX) 抑制剂。 | |||
T14560 | BI-2545 | Others | Others |
BI-2545 is an autotaxin (ATX) inhibitor that significantly reduces LPA. For human ATX and rat ATX, the IC50s values are 2.2 nM and 3.4 nM , respectively. | |||
T28300 |
PAT-347 sodium
PAT-347,PAT347,PAT 347 |
||
PAT-347 is a potent inhibitor of Autotaxin (ATX), a secreted enzyme responsible for the hydrolysis of lysophosphatidylcholine (LPC) to the bioactive lysophosphatidic acid (LPA) and choline. | |||
T70275 |
PAT-347
|
||
PAT-347 is a potent Autotaxin Inhibitor. Autotaxin (ATX) is a secreted enzyme responsible for the hydrolysis of lysophosphatidylcholine (LPC) to the bioactive lysophosphatidic acid (LPA) and choline. The ATX-LPA signaling pathway is implicated in cell survival, migration, and proliferation; thus, the inhibition of ATX is a recognized therapeutic target for a number of diseases including fibrotic diseases, cancer, and inflammation, among others. | |||
T63575 |
PF-8380 hydrochloride
|
||
PF-8380 hydrochloride 是一种有效的autotaxin 抑制剂,体外酶实验和人类全血细胞实验中,IC50分别为 2.8 nM 和 101 nM。 | |||
T81804 |
MEY-003
|
||
MEY-003是针对Autotaxin(ATX)的抑制剂,具有对hATX-β和hATX-ɣ的EC50值分别为460 nM和1.09 μM(LPC18:1分析条件下)。作为一种非竞争性抑制剂,其Ki值为432 nM。该化合物主要应用于ATX相关疾病的研究领域。 | |||
T64141 |
ATX inhibitor 11
|
||
ATX inhibitor 11 是 ATX (autotaxin) 的有效抑制剂 (IC50: 2.7 nM)。ATX inhibitor 11 能够缓解小鼠纤维化模型中纤维化组织的严重程度,有效减少纤维化生物标志物 α-SMA 的沉积。ATX inhibitor 11 能够用于研究肺纤维化。 | |||
T69647 |
UCM-05194
|
||
UCM-05194 is a potent Agonist of the Type 1 Lysophosphatidic Acid Receptor (LPA1). UCM-05194 Shows Efficacy in Neuropathic Pain Amelioration. UCM-05194 stands out as the most potent and selective LPA1 receptor agonist described so far (Emax = 118%, EC50 = 0.24 μM, KD = 19.6 nM; inactive at autotaxin and LPA2-6 receptors). | |||
T63325 |
ATX inhibitor 9
|
||
ATX inhibitor 9 是增稠的杂芳基衍生物化合物,也是 ATX 的有效抑制剂。其中 Autotaxin (ATX),也称为 ENPP2,是一种主要在肺癌细胞、支气管上皮细胞和肺泡巨噬细胞中高度表达的分泌酶。ATX inhibitor 9 对癌症或纤维退行性疾病具有研究潜力。 | |||
T61612 |
ATX inhibitor 15
|
||
ATX inhibitor 15 (compound 30) is an indole-based carbamate derivative with a strong inhibitory effect on autotaxin (ATX), demonstrated by an IC50 of 2.17 nM. Additionally, ATX inhibitor 15 effectively inhibits ATX activity in vivo and suppresses the expression of pro-fibrotic genes. Furthermore, ATX inhibitor 15 exhibits protective effects in lung fibrosis induced by Bleomycin in mice [1]. | |||
T38000 |
Lysosphingomyelin (d18:1)
|
||
Sphingomyelins are complex membrane lipids composed of phosphorylcholine, sphingosine, and an acylated group, such as a fatty acid. Lysosphingomyelin is a naturally-occurring lipid which is produced by the removal of the acylated group of sphingomyelin by a deacylase. Lysosphingomyelin may, in turn, serve as a substrate for autotaxin, which removes choline to produce sphingosine-1-phosphate. The receptors and signaling pathways that are activated by lyso-sphingosine are diverse and vary between ... | |||
T12372 |
PAT-505
|
EGFR | Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors |
PAT-505 是一种可口服且具有选择性和高效性的自体表皮生长因子抑制剂(在 Hep3B 细胞中的 IC50 为 2 nM,在人体血液中的 IC50 为 9.7 nM,在小鼠血浆中的 IC50 为 62 nM)。 |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-00463 |
ENPP2 Protein, Cynomolgus, Recombinant (His)
ENPP2,ectonucleotide pyrophosphatase/phosphodiesterase 2, |
Cynomolgus | HEK293 Cells |
ENPP2 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 96 kDa and the accession number is XP_005564040.1. | |||
TMPY-02778 |
ENPP2 Protein, Human, Recombinant (His)
ATX,ectonucleotide pyrophosphatase/phosphodiesterase 2,A... |
Human | HEK293 Cells |
ENPP2 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 96 kDa and the accession number is AAH34961.1. |