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Cat. No.	Product Name	Target	Signaling Pathways
T10380	AS19	5-HT Receptor	GPCR/G Protein; Neuroscience
	AS19 is a potent, selective 5-HT7 receptor agonist (IC50: 0.83 nM; Ki: 0.6 nM). AS19 is selective for 5-HT7 over 5-HT1A, 5-HT1B, 5-HT1D, and 5-HT5A receptors (Kis: 89.7 nM, 490 nM, 6.6 nM and 98.5 nM, respectively).
T14327	AS1949490	Phosphatase	Metabolism
	AS1949490 是选择性SHIP-2抑制剂，其IC50=620 nM。它能够通过上调L6肌管GLUT1基因激活葡萄糖代谢。
T68321	AS1940477
	AS1940477 is p38 MAPK inhibitor. AS1940477 inhibited the enzymatic activity of recombinant p38α and β isoforms but showed no effect against other 100 protein kinases including p38γ and δ isoforms. In human peripheral blood mononuclear cells, AS1940477 inhibited lipopolysaccharide (LPS)- or phytohemagglutinin A (PHA)-induced production of proinflammatory cytokines, including TNFα, IL-1β, and IL-6 at low concentrations (LPS/TNFα, IC(50)=0.45n M; PHA/TNFα, IC(50)=0.40 nM). In addition, equivalent c...
T70402	LAS195319
	LAS195319 is a potent and selective inhaled PI3Kδ Inhibitor (IC50 = 0.5 nM) for the Treatment of Respiratory Diseases.
T68243	AS1975063
	AS1975063 is a GPR40 agonist.
T27799	LAS191859 LAS-191859,LAS 191859
	LAS191859 is a CRTH2/DP2 antagonist with IC50 values of 7.6, 9.58, 14 and 15.5nM for recombinant guinea pig, human, rat and mouse CRTH2/DP2 receptors, respectively. LAS191859 has a residence time half-life of 21h at CRTh2 that translates into a long-lasti
T26663	AS1928370
	AS1928370 is an antagonist of transient receptor potential vanilloid 1 (TRPV1).
T11818	LAS191954	PI3K	PI3K/Akt/mTOR signaling
	LAS191954 is a selective, potent and orally active PI3Kδ inhibitor for inflammatory diseases treatment(IC50 : 2.6 nM).
T25111	AS1938909 AS 1938909,AS-1938909
	AS1938909 is a SHIP2 inhibitor that works by increasing Akt phosphorylation, glucose consumption, and glucose uptake in L6 myotubes, specifically upregulating the GLUT1 gene.
T26662	AS1907417 AS-1907417,AS 1907417
	AS1907417 is a GPR119 agonist.
T74709	LAS190792
	LAS190792 (AZD8999) 是一种毒蕈碱 (muscarinic) 拮抗剂及β2-肾上腺素能受体 (β2-adrenoceptor) 激动剂，其pIC50值针对 M1, M2, M3, M4, M5, β1, β2, β3 分别为 8.9, 8.8, 8.8, 9.2, 8.2, 7.5, 9.1, 5.6。该化合物作为支气管扩张剂具有应用潜力。

化合物

Cat.No: T10380

Target: 5-HT Receptor

Cat.No: T14327

Target: Phosphatase

Cat.No: T68321

Cat.No: T70402

Cat.No: T68243

Cat.No: T27799

Synonym: LAS-191859,LAS 191859

Cat.No: T26663

Cat.No: T11818

Target: PI3K

Cat.No: T25111

Synonym: AS 1938909,AS-1938909

Cat.No: T26662

Synonym: AS-1907417,AS 1907417

Cat.No: T74709

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