Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T6065 |
Triciribine
VD-0002,Tricyclic nucleoside,NSC 154020,曲西立滨,API-2,TCN |
Akt; HIV Protease; DNA/RNA Synthesis | Cell Cycle/Checkpoint; Cytoskeletal Signaling; DNA Damage/DNA Repair; Microbiology/Virology; PI3K/Akt/mTOR signaling; Proteases/Proteasome |
Triciribine (NSC-154020) 是一种 DNA 合成抑制剂,也抑制 Akt 和 HIV-1/2,IC50分别为 130 nM 和 0.02-0.46 μM。 | |||
T78146 |
NaPi2b-IN-2
|
Others | Others |
NaPi2b-IN-2(化合物5)为钠依赖性转运蛋白2b(SLC34A2,NaPi2b)的高效抑制剂,对人NaPi2b的IC50为38 nM。该化合物适用于高磷血症研究。 | |||
T70605 | NaPi2b Inhibitor 15 | ||
NaPi2b is primarily expressed in the small intestine, lungs, and testes and plays an important role in phosphate homeostasis. The inhibition of NaPi2b, responsible for intestinal phosphate absorption, is considered to reduce serum phosphate levels, making it a promising therapeutic approach for hyperphosphatemia |