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4

抑制剂 & 化合物

5

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T38206	3-Cysteinylacetaminophen (trifluoroacetate salt) APAP-Cys,3-(cysteine-S-yl)acetaminophen,3-Cysteinylacetaminophen (trifluoroacetate salt)
	3-Cysteinylacetaminophen is an acetaminophen-protein adduct formed during the metabolism of acetaminophen.[1],[2] 3-Cysteinylacetaminophen has been found in isolated human serum following therapeutic and supratherapeutic doses of acetaminophen and in the presence and absence of hepatotoxicity.[3],[4] In mice, 3-cysteinylacetaminophen decreases renal glutathione (GSH) levels, an effect that can be blocked by the γ-glutamyl inhibitor acivicin.
T34785	TAPAP 3-Tapap
	TAPAP binds to thrombin and trypsin.
T83051	Anti-inflammatory agent 61
	Anti-inflammatory agent 61 (Compound 5b)为一种高效抗炎化合物，能够降低LPS诱导的RAW 264.7细胞中的TNF-α表达，并可缓解APAP引起的HepG2细胞炎症。
T69218	PUMAi HCl
	PUMAi is an inhibitor of p53 up-regulated modulator of apoptosis (PUMA), a BH3-only Bcl-2 family member, mitigating acetaminophen (APAP)-induced hepatocyte necrosis and liver injury.

化合物

3-Cysteinylacetaminophen (trifluoroacetate salt)

Cat.No: T38206

Synonym: APAP-Cys,3-(cysteine-S-yl)acetaminophen,3-Cysteinylacetaminophen (trifluoroacetate salt)

Cat.No: T34785

Synonym: 3-Tapap

Anti-inflammatory agent 61

Cat.No: T83051

Cat.No: T69218

Cat. No.	Product Name	Target	Signaling Pathways
T0065	Acetaminophen 对乙酰氨基酚,醋氨酚,4-Acetamidophenol,4'-Hydroxyacetanilide,APAP,Paracetamol	COX; Endogenous Metabolite; Histone Acetyltransferase	Chromatin/Epigenetic; Immunology/Inflammation; Metabolism; Neuroscience
	Acetaminophen (APAP) 是一种 COX 抑制剂，抑制 COX-1 和 COX-2 (IC50=113.7/25.8 μM)。Acetaminophen 具有解热镇痛活性，以及较弱的抗炎活性。
T7036	2,4'-Dihydroxybenzophenone	Antioxidant	oxidation-reduction
	2,4'-Dihydroxybenzophenone 可有效保护 C57BL/6J 小鼠免受 APAP 诱导的肝毒性。它对可卡因诱导的小鼠急性肝毒性和神经毒性具有保护作用。其机制可能与其抗氧化活性有关。
TWS1977	Kamebakaurin 尾叶香茶菜丙素,Kamebakaurine	NF-κB	NF-κB
	Kamebakaurin (Kamebakaurine) 是一种提取自Isodon japonicus 中的天然产物，是一种NF-κB 的抑制剂，能够抑制 p50 的 DNA 结合活性。
T82219	Heilaohuguosu F
	Heilaohuguosu F (compound 6)为一类四氢呋喃木脂素，表现出轻度肝脏保护效果。该化合物对于APAP诱导的HepG2细胞所呈现的肝毒性具有微弱的防护作用。
T82748	Celosin L
	Celosin L，一种三萜皂苷，具备保肝活性。该化合物能够保护HepG2 细胞免受 APAP 诱导的肝毒性伤害。

天然产物

Cat.No: T0065

Synonym: 对乙酰氨基酚,醋氨酚,4-Acetamidophenol,4'-Hydroxyacetanilide,APAP,Paracetamol

Target: COX, Endogenous Metabolite, Histone Acetyltransferase

2,4'-Dihydroxybenzophenone

Cat.No: T7036

Target: Antioxidant

Cat.No: TWS1977

Synonym: 尾叶香茶菜丙素,Kamebakaurine

Target: NF-κB

Heilaohuguosu F

Cat.No: T82219

Cat.No: T82748

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