9
1
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T26834 |
BL-1020 Mesylate
CYP-1020 Mesylate |
Dopamine Receptor; GABA Receptor | GPCR/G Protein; Membrane transporter/Ion channel; Neuroscience |
BL-1020 Mesylate (CYP-1020 Mesylate) 是一种可口服的 GABA A 受体激动剂和 D2 拮抗剂,可降低多巴胺活性并增强GABAA活性。BL-1020 Mesylate 可用于研究神经分裂、阿尔茨海默症和双向认知障碍。 | |||
T83082 |
Anticancer agent 168
|
||
Anticanceragent 168(compound d16)是一种DNA2抑制剂。该化合物能够促进细胞凋亡(apoptosis),引起细胞周期在S期显著停滞,并在含mutp53肿瘤中显示出抗癌效应,有助于克服化疗耐药性。 | |||
T63376 |
CB 168
|
||
CB 168是有效的靶向异亮基 tRNA 合成酶 (IleRS) 选择性氨基酰基氨基酰芳基四唑抑制剂。 | |||
T78041 |
Tat-peptide control 168-189 TFA
|
||
Tat-peptide 168-189 是一款标记有 Tat 的细胞渗透融合肽,对应回大鼠 G3BP1 的168-189残基。此配合物末端整合了HIV Tat 序列的一个高度非保守部分,以促进其穿透细胞膜。作为Tat-peptide 168-189 TFA的阴性对照,Tat-peptide 168-189 TFA 已被证实可促进轴突生长和增加神经元的突触数目。 | |||
T28862 |
ST-168
ST168,ST 168 |
||
ST-168 is a potent inhibitor of PI3K and MEK. ST-168 displays improved PI3K and MEK1 isoform inhibition. ST-168 demonstrated a 2.8-, 2.7-, 23-, and 2.5-fold improved inhibition toward the PI3Kα, PI3Kβ, PI3Kδ, and PI3Kγ isoforms and a 2.2-fold improvement | |||
T62273 |
Vulolisib
|
||
Vulolisib 是一种口服具有活力、有效的磷脂酰肌醇 3 激酶 (PI3K) 抑制剂,能够作用于 PI3Kα (IC50: 0.2 nM)、PI3Kβ (IC50: 168 nM)、PI3Kγ (IC50: 90 nM)、 PI3Kδ (IC50: 49 nM)。Vulolisib 具有抗肿瘤活性,对癌细胞表现出抗增殖活性。 | |||
T76872 | Neihulizumab | ||
Neihulizumab (ALTB-168) 是一种免疫检查点激动性抗体,可与人 CD162 (PSGL-1)结合,导致活化的 T 细胞下调。Neihulizumab 可用于类固醇难治性急性移植物抗宿主病 (SR-aGVHD)、银屑病、银屑病关节炎和溃疡性结肠炎的研究。 | |||
T38020 |
O-Benzylhydroxylamine (hydrochloride)
|
||
O-Benzylhydroxylamine is a building block.1,2It has been used in the synthesis of β-lactam inhibitor precursors and fluoroquinolone derivatives with antibiotic activity. 1.Bellettini, J.R., and Miller, M.J.A short synthesis of an important precursor to a new class of bicyclic β-lactamase inhibitorsTetrahedron Lett.38(2)167-168(1997) 2.Asadipour, A., Moshafi, M.H., Khosravani, L., et al.N-substituted piperazinyl sarafloxacin derivatives: synthesis and in vitro antibacterial evaluationDaru.26(2)19... | |||
T35836 |
PMX-205 (trifluoroacetate salt)
|
||
PMX-205 is a cyclic hexapeptide that acts as a potent antagonist of C5a receptor (C5aR; IC50= 31 nM).1It is orally active and blocks inflammatory signaling and symptoms in animal models of colitis and allergic asthma.2,3PMX-205 is also brain penetrant and reduces neuroinflammation and neurodegeneration in an animal model of Alzheimer's disease.4 1.March, D.R., Proctor, L.M., Stoermer, M.J., et al.Potent cyclic antagonists of the complement C5a receptor on human polymorphonuclear leukocytes. Rela... |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T35779 |
Oosporein
|
||
Oosporein is a mycotoxin that has been found inBeauveriaand has diverse biological activities.1,2It is cytotoxic to Sf9 and Sf21 insect cells with 50% cytotoxic concentration (CC50) values of 4.23 and 10.43 μM, respectively.3Oosporin induces lethality in day-old cockerels (LD50= 6.12 mg/kg).4It inhibits Na+/K+-, Ca2+-, and Mg2+-ATPase activities by 27, 52, and 100%, respectively, in equine erythrocyte ghosts when used at a concentration of 200 μg/ml.2Oosporein inhibits herpes simplex 1 (HSV-1), ... |