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Search Results for " aha "

16

抑制剂 & 化合物

6

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T41090	L-Azidohomoalanine hydrochloride H-L-Aha-OH hydrochloride	PROTAC Linker	PROTAC
	L-Azidohomoalanine hydrochloride (H-L-Aha-OH hydrochloride) 是一种基于烷基链的 PROTAC 接头。
T1592	Acetohydroxamic acid Methylhydroxamic acid,Acetic acid,Lithostat,AHA,oxime,N-Hydroxyacetamide,乙酰氧肟酸	MMP; Antibacterial	Microbiology/Virology; Proteases/Proteasome
	Acetohydroxamic acid (N-Hydroxyacetamide) 是一种不可逆的细菌和植物尿素酶抑制剂，可研究慢性尿路感染。
T62307	Aha1/Hsp90-IN-1
	Aha1/Hsp90-IN-1 (Compound 17) 是一种 Aha1/Hsp90 complex 抑制剂，对 tau 蛋白聚集具有抑制作用。Aha1/Hsp90-IN-1 能够破坏 Aha1/Hsp90 的相互作用 (IC50: 3.32 μM)。
T19556	SAHA chloroalkane T1	Others	Others
	SAHA chloroalkane T1 is a novel compound formed by combining Vorinostat (SAHA) with a chloroalkane capture tag, referred to as T1. This innovative approach involves tethering the SAHA molecule with the T1 tag, resulting in the formation of SAHA chloroalkane T1.
T25565	Kahalalide A
	Kahalalide A has antimycobacterial activity isolated from the mollusk Elysia rufescens.
T71011	Perfluorinated SAHA
	Perfluorinated SAHA is an HDAC inhibitor for use in cancer treatment regimens, with demonstrated greater antiproliferative properties than SAHA . PFSAHA has also been shown to have higher selectivity for PA3774, an HDAC-like enzyme from P. aeruginosa, as well as other HDACs, which may prove beneficial for developing novel chemotherapeutic treatments for cancer.
T27804	LCAHA
	LCAHA is a USP2a inhibitor. LCAHA inhibits growth of cyclin D1-dependent cells.
T36105	coumarin-SAHA coumarin-Suberoylanilide Hydroxamic Acid,coumarin-SAHA
	Suberoylanilide hydroxamic acid (SAHA) is a class I and class II histone deacetylase (HDAC) inhibitor that binds directly to the catalytic site of the enzyme thereby blocking substrate access. [1] coumarin-Suberoylanilide hydroxamic acid (c-SAHA) is a SAHA derivative where the anilino cap" group is replaced by 7-amino-4-methylcoumarin to produce a fluorescent probe that competitively binds HDAC. [2] The fluorescence excitation and emission maxima of free c-SAHA is 325 and 400 nm
T125152	Isomahanimbine
	Isomahanimbine 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T125152。
T21749	4-iodo-SAHA
	4-Iodo-SAHA (1k) 是一种具有口服活性的I 类和II 类histone deacetylase (HDAC)抑制剂，对 Skbr3、 HT29、 U937、 JA16 和 HL60细胞的EC50值分别为1.1、0.95、0.12、0.24、0.85和1.3 μM。4-Iodo-SAHA (1k) 可用于癌症的研究。
T25342	Discobahamin A
	Discobahamin A is a bioactive peptide isolated from a new species of the Bahamian deep water marine sponge Discodermia. It is a growth of Candida albicans inhibitor.
T125848	Isomahanine
	Isomahanine 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T125848。
T25343	Discobahamin B
	Discobahamin B is a bioactive peptide isolated from a new species of the Bahamian deep water marine sponge Discodermia. It is a growth of Candida albicans inhibitor.
T73454	SAHA-OH	HDAC	Chromatin/Epigenetic; DNA Damage/DNA Repair
	SAHA-OH为HDAC6选择性抑制剂（IC50=23 nM），对HDAC6具有10至47倍选择性，相较于HDAC1、2、3及8。该化合物展现抗炎活性，能够降低巨噬细胞凋亡。
T35765	SAHA-BPyne
	Suberoylanilide hydroxamic acid (SAHA) is a class I and class II histone deacetylase (HDAC) inhibitor that binds directly to the catalytic site of the enzyme thereby blocking substrate access. SAHA-BPyne is a SAHA derivative with a benzophenone crosslinker and an alkyne tag intended to be used for profiling HDAC activities in proteomes and live cells. Such terminal alkyne groups can be used in linking reactions, known as click chemistry, characterized by high dependability and specificity of azi...
T80422	Phoenixin-14 PNX-14	GNRH Receptor	GPCR/G Protein
	Phoenixin-14 (PNX-14) 是一种具有内源性活性的异构体，能通过激活AHA GnRH系统发挥抗焦虑效果，并抑制缺血/再灌注所诱导的小胶质细胞毒性。

化合物

L-Azidohomoalanine hydrochloride

Cat.No: T41090

Synonym: H-L-Aha-OH hydrochloride

Target: PROTAC Linker

Acetohydroxamic acid

Cat.No: T1592

Synonym: Methylhydroxamic acid,Acetic acid,Lithostat,AHA,oxime,N-Hydroxyacetamide,乙酰氧肟酸

Target: MMP, Antibacterial

Aha1/Hsp90-IN-1

Cat.No: T62307

SAHA chloroalkane T1

Cat.No: T19556

Target: Others

Cat.No: T25565

Perfluorinated SAHA

Cat.No: T71011

Cat.No: T27804

Cat.No: T36105

Synonym: coumarin-Suberoylanilide Hydroxamic Acid,coumarin-SAHA

Cat.No: T125152

Cat.No: T21749

Cat.No: T25342

Cat.No: T125848

Cat.No: T25343

Cat.No: T73454

Target: HDAC

Cat.No: T35765

Cat.No: T80422

Synonym: PNX-14

Target: GNRH Receptor

Cat. No.	Product Name	Target	Signaling Pathways
TN5082	Swietemahalactone	Antifection	Microbiology/Virology
	Swietemahalactone exhibits antibacterial activity.
TN6198	Mahanine
	Mahanine has effects on the activation of the apoptotic pathway in human leukemia U937 cells, causes the mitochondrial membranes to lose their permeability, resulting in caspase-3 activation and apoptosis. Mahanine can reverse an epigenetically silenced g
TN6099	Mahanimbilol Mahanimbinol
	Mahanimbilol 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 TN6099，CAS号为 77156-13-9。
T81877	Mahanimbidine
	Mahanimbidine为一种萜类生物碱，可从Murraya koenigii Spreng的叶与茎皮中提取分离。
T15949	Mahanimbine	AChE	Neuroscience
	Mahanimbine 存在于Murraya koenigii 的根、叶和茎中，是从Murraya koenigii 中的提取的一种具有口服活性的生物碱。Mahanimbine 具有乙酰胆碱酯酶抑制活性，可抑制了高脂肪饮食（HFD）引起的小鼠代谢并发症的发展，对科尼氏分枝杆菌叶对链脲佐菌素诱导的糖尿病大鼠胰腺β细胞组织病理学变化有作用。
TN4933	Sahandol	Antifection	Microbiology/Virology
	Sahandol shows antiprotozoal activity against P. falciparum and T. brucei rhodesiense.

天然产物

Swietemahalactone

Cat.No: TN5082

Target: Antifection

Cat.No: TN6198

Cat.No: TN6099

Synonym: Mahanimbinol

Cat.No: T81877

Cat.No: T15949

Target: AChE

Cat.No: TN4933

Target: Antifection

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