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Search Results for " aep "

7

抑制剂 & 化合物

1

天然产物

3

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T40872	17-AEP-GA
	17-AEP-GA is a highly effective HSP90 antagonist compound that exhibits potent inhibition against the proliferation, survival, migration, and invasion of glioblastoma cells. Additionally, it demonstrates ADCs Toxin activity.
T61004	AEP-IN-1
	APE-IN-1 可用于阿尔茨海默病的早期诊断和药物研发。APE-IN-1 是一种有效的天冬酰胺内肽酶(APE) 抑制剂，IC50值为 89 nM。
T9713	δ-secretase inhibitor 11	Beta Amyloid; Caspase	Apoptosis; Neuroscience; Proteases/Proteasome
	δ-secretase inhibitor 11是一种分泌酶抑制剂，可用作阿尔茨海默病（AD）治疗转化开发的先导化合物。
T18304	Mal-VC-PAB-ABAEP-Azonafide	Others	Others
	Mal-VC-PAB-ABAEP-Azonafide, an ADC (antibody-drug conjugate) linker-drug conjugate, demonstrates potent antitumor activity. It incorporates Azonafide, a cytotoxin, connected through the ADC linker Mal-VC-PAB[1].
T33578	Naepaine hydrochloride
	Naepaine hydrochloride is a biochemical.
T25847	NAEPA
	NAEPA, an LPA mimetic, is a selective agonist of the lysophosphatidic acid-1 (LPA1) receptor.
T38116	Fmoc-Ala-Glu-Asn-Lys-NH2 Fmoc-Ala-Glu-Asn-Lys-NH2
	Fmoc-Ala-Glu-Asn-Lys-NH2 is a peptide inhibitor that selectively targets asparagine endopeptidase (AEP) and inhibits the cleavage of amyloid precursor protein (APP). AEP, a pH-controlled cysteine proteinase, plays a crucial role in the proteolytic processing of APP, and its activity is enhanced during the aging process [1].

化合物

Cat.No: T40872

Cat.No: T61004

δ-secretase inhibitor 11

Cat.No: T9713

Target: Beta Amyloid, Caspase

Mal-VC-PAB-ABAEP-Azonafide

Cat.No: T18304

Target: Others

Naepaine hydrochloride

Cat.No: T33578

Cat.No: T25847

Fmoc-Ala-Glu-Asn-Lys-NH2

Cat.No: T38116

Synonym: Fmoc-Ala-Glu-Asn-Lys-NH2

Cat. No.	Product Name	Target	Signaling Pathways
T4703	(2-Aminoethyl)phosphonic acid 2-Aminoethylphosphonic acid,2-氨基乙基膦酸,Ciliatine,2-AEP	Others; Endogenous Metabolite	Metabolism; Others
	(2-Aminoethyl)phosphonic acid (2-Aminoethylphosphonic acid) 主要在尿液中检测到。(2-Aminoethyl)phosphonic acid 参与许多酶促反应，也是其他转化产物的母体化合物，包括但不限于神经酰胺 2-(甲氨基)乙基膦酸酯、N-(2-膦乙基)胆酰胺和 CMP-2-氨基乙基膦酸酯。

天然产物

(2-Aminoethyl)phosphonic acid

Cat.No: T4703

Synonym: 2-Aminoethylphosphonic acid,2-氨基乙基膦酸,Ciliatine,2-AEP

Target: Others, Endogenous Metabolite

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-00876	Legumain Protein, Mouse, Recombinant (His) AI746452,AEP,AU022324,Prsc1,legumain	Mouse	HEK293 Cells
	Legumain Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 49.8 kDa and the accession number is A2RTI3.
TMPY-06640	Legumain Protein, Human, Recombinant (His) PRSC1,AEP,legumain,LGMN1	Human	HEK293 Cells
	Legumain Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 49.12 kDa and the accession number is Q99538.
TMPK-01146	LGMN Protein, Human, Recombinant (His) AI746452,Legumain,LGMN1,Prsc1,AEP,LGMN,AU022324	Human	HEK293 Cells
	Recently, functional studies have demonstrated that legumain (LGMN) cleaves both amyloid β-protein precursor and tau, promoting senile plaques and formation of neurofibrillary tangles, which may play a crucial role in the pathogenesis of Alzheimer's disease (AD). In single-variant association analysis, none of the common variants in LGMN were statistically significant. In gene-based analysis, the LGMN gene also showed no association with AD.

重组蛋白

Legumain Protein, Mouse, Recombinant (His)

Cat.No: TMPY-00876

Species: Mouse

Expression System: HEK293 Cells

Legumain Protein, Human, Recombinant (His)

Cat.No: TMPY-06640

Species: Human

Expression System: HEK293 Cells

LGMN Protein, Human, Recombinant (His)

Cat.No: TMPK-01146

Species: Human

Expression System: HEK293 Cells

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