Cat. No. | Product Name | Target | Signaling Pathways |
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T70096 |
AEG40730 HCl
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AEG40730 is a potent and selective IAP antagonist and a BIR-binding tetrapeptide. AEG40730 binds to cIAP1 and cIAP2, facilitates their autoubiquitination and proteosomal degradation, and causes a dramatic reduction in RIP1 ubiquitination. Treatment with nanomolar concentrations of AEG40730 resulted in the loss of both XIAP and c-IAP1 proteins, albeit with different kinetics. | |||
T70095 |
Mps1-IN-1 dihydrochloride
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Mps1-IN-1 dihydrochloride 是一种有效的,ATP 竞争性 Mps1激酶抑制剂,IC50为 367 nM。Mps1-IN-1 dihydrochloride 抑制 Mps1有丝分裂激酶活性并沉默纺锤体组装检查点 (SAC) 功能。Mps1-IN-1 dihydrochloride 降低癌细胞和“正常”细胞的活力。 |