Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T24997 |
ABT-510 acetate
ABT 510 acetate |
Apoptosis | Apoptosis |
ABT-510 acetate 是一种内源性抗血管生成的 TSP 肽抑制剂,是一种凝血酶原类似物,具有抗炎抗癌和抗血管生成活性,能诱导肿瘤细胞凋亡并抑制上皮性卵巢癌正位、同种异体模型中的卵巢肿瘤生长。ABT-510 acetate 可减少小鼠炎症性肠病模型的血管生成和炎症反应,可用于癌症 (尤其是上皮性卵巢癌) 以及炎症性肠病 (IBD) 的研究。 | |||
T69599 |
ABT-510
|
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ABT-510 is synthetic peptide that mimics the anti-angiogenic activity of the endogenous protein thrombospondin-1 (TSP-1). ABT-510 inhibits the actions of several pro-angiogenic growth factors important to tumor neovascularization; these pro-angiogenic growth factors include vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF)), hepatocyte growth factor (HGF), and interleukin 8 (IL-8). |