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Cat. No. Product Name Target Signaling Pathways
T26412 A 274

A-274,A274

A 274 is a highly aromatic, monosubstituted phenol antioxidant generated during differentiation of neuroblastoma cells.
T39916 GNE-274

GNE-274, a non-degrader compound structurally similar to GDC-0927 (an ER degrader), serves as a partial ER agonist in breast cancer cell lines without triggering ER turnover. Notably, GNE-274 enhances chromatin accessibility at ER-DNA binding sites, unlike GDC-0927. Acting as a potent inhibitor of the ER-ligand binding domain (LBD), GNE-274 exhibits potential for cancer research purposes.
T71974 ABI-274

ABI-274 is a novel potent colchicine binding site inhibitor (CBSI) and tubulin inhibitor.
T71250 NCX-274

NCX-274 is a ROCK inhibitor and NO-donating anti-glaucoma agent
T77629 FD274

FD 274,FD-274

PI3K; mTOR PI3K/Akt/mTOR signaling
FD274 是一种高效的 PI3K/mTOR 双重抑制剂,对 PI3Kα/β/γ/δ 和 mTOR 具有抑制作用, IC50 分别为 0.65 nM、1.57 nM、0.65 nM、0.42 nM 和 2.03 nM。 FD274AML 细胞系抗增殖实验中显示出显着的抗增殖活性。 FD274 在 HL-60 异种移植模型中表现出剂量依赖性的坑肿瘤生长活性。 FD274具有用于急性髓系白血病研究的潜力。
T79032 Enpp-1-IN-17

Enpp-1-IN-17 (example 274) 是一种ENPP1抑制剂,其对cGAMP水解的Ki值在100 nM-1 μM范围内,而对ATP水解的Ki值则大于1 μM。该化合物在抑制cGAMP水解方面相对于ATP水解的选择性比率超过6.4。
T36974 D-threo-PPMP hydrochloride

D-threo-PPMP is a glucosylceramide (GlyCer) synthetase inhibitor.1,2It is the active enanantiomer and enzymatic inhibitory component of the racemic DL-threo-PPMP . In MDCK kidney epithelial cells, D-threo-PPMP induces a 70% reduction in cell growthin vitroat 20 μM and significantly inhibits DNA synthesis at 3 μM.3[Matreya, LLC. Catalog No. 1865] 1.Shen, W., Henry, A.G., Paumier, K.L., et al.Inhibition of glucosylceramide synthase stimulates autophagy flux in neuronsJ. Neurochem.129(5)884-894(201...

化合物

A 274
Cat.No: T26412
Synonym: A-274,A274
Target:
GNE-274
Cat.No: T39916
Synonym:
Target:
ABI-274
Cat.No: T71974
Synonym:
Target:
NCX-274
Cat.No: T71250
Synonym:
Target:
FD274
Cat.No: T77629
Synonym: FD 274,FD-274
Target: PI3K, mTOR
Enpp-1-IN-17
Cat.No: T79032
Synonym:
Target:
D-threo-PPMP hydrochloride
Cat.No: T36974
Synonym:
Target:
TargetMol Loading
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