Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T16440 |
Ibrutinib Racemate
PCI-32765 (Racemate) |
Others | Others |
Ibrutinib is a selective, irreversible Btk inhibitor (IC50: 0.5 nM). Ibrutinib Racemate is the racemate of Ibrutinib. | |||
T13814 |
Pemafibrate (racemate)
K13675 (racemate) |
Others | Others |
Pemafibrate racemate is the racemate of pemafibrate | |||
T13450L |
GNE-140 racemate
GNE-140 (racemate) |
Others | Others |
GNE-140 is a potent inhibitor of lactate dehydrogenase A (LDHA). GNE-140 is a racemate mixture of (R)-GNE-140 and (S)-GNE-140. | |||
T1835 |
Ibrutinib
伊布替尼,依鲁替尼,PCI-32765 |
Tyrosine Kinases; Src; BTK; Ligands for Target Protein for PROTAC | Angiogenesis; PROTAC; Tyrosine Kinase/Adaptors |
Ibrutinib (PCI-32765) 是一种不可逆的、选择性的 Btk 抑制剂,IC50=0.5 nM,它是一种 Btk 配体,用于合成一系列 PROTAC 分子,如 P13I。P13I 作用于人 Burkitt’s 淋巴瘤 RAMOS 细胞,浓度为 10 和 100 nM 时,分别降解 73% 和 89% Btk。 |