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Cat. No. Product Name Target Signaling Pathways
T2665 4EGI-1

4EGI 1

Apoptosis; PERK; Autophagy Apoptosis; Autophagy
4EGI-1 是一种竞争性 eIF4E/eIF4 g 相互作用抑制剂,与 eIF4E 结合,Kd 值为 25 μM。
T37099 (Z)-4EGI-1

(Z)-4EGI-1 is the Z-isomer of 4EGI-1 and is an inhibitor of eIF4E/eIF4G interaction and of translation initiation. (Z)-4EGI-1 effectively binds to eIF4E with an IC50 of 43.5 μM and a Kd value of 8.74 μM. (Z)-4EGI-1 has anticancer activity[1][2]. [1]. Khuloud Takrouri, et al. Structure-activity Relationship Study of 4EGI-1, Small Molecule eIF4E/eIF4G Protein-Protein Interaction Inhibitors. Eur J Med Chem. 2014 Apr 22;77:361-77. [2]. Poornachandran Mahalingam, et al. Synthesis of Rigidified eIF4E/...

化合物

4EGI-1
Cat.No: T2665
Synonym: 4EGI 1
Target: Apoptosis, PERK, Autophagy
(Z)-4EGI-1
Cat.No: T37099
Synonym:
Target:
TargetMol Loading
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