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抑制剂 & 化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T4420	4-Hydroxytamoxifen ICI 79280,(Z)-4-hydroxy Tamoxifen,4-羟基他莫昔芬,trans-4-Hydroxytamoxifen	Estrogen Receptor/ERR; Estrogen/progestogen Receptor	Endocrinology/Hormones
	4-Hydroxytamoxifen (ICI 79280) 是 Tamoxifen 的活性代谢产物，是一种雌激素受体调节剂 (SERM)，具有选择性和口服有效性。4-Hydroxytamoxifen 具有抗肿瘤活性，可用于乳腺癌的研究。
T6743	(E/Z)-4-Hydroxytamoxifen 4-羟基他莫昔芬,(E/Z)-4-羟基他莫昔芬,Afimoxifene,4-Hydroxytamoxifen	Estrogen Receptor/ERR; Estrogen/progestogen Receptor	Endocrinology/Hormones
	(E/Z)-4-Hydroxytamoxifen (Afimoxifene) 是 tamoxifen 的活性代谢物和选择性雌激素受体（ER）调节剂，广泛用于乳腺癌的治疗和化学预防治疗。
T15186	(E)-4-Hydroxytamoxifen	Others	Others
	(E)-4-Hydroxytamoxifen is a less active isomer of (Z)-4-hydroxytamoxifen and also is an estrogen receptor modulator.
T71576	SIM010603
	SIM010603 is a structurally novel, oral, multi-targeted receptor tyrosine kinase inhibitor. SIM010603 inhibited stem cell factor receptor (Kit), vascular endothelial growth factor receptor-2 (VEGFR-2), platelet-derived growth factor receptor-β (PDGFR-β), glial cell line-derived neurotrophic factor receptor (Rearranged during Transfection; RET), and Fms-like tyrosine kinase-3 (FLT3) with IC(50) values between 5.0 and 68.1 nmol/l. SIM010603 inhibited the phosphorylation of PDGFR-β and VEGFR-2. Mor...
T71578	Endoxifen mesylate
	Endoxifen, also known as N-desmethyl-4-hydroxytamoxifen, is a chemical that is under development for estrogen receptor-positive breast cancer. It is also being evaluated as an antipsychotic for treatment of mania and other psychotic disorders. Endoxifen is a nonsteroidal selective estrogen receptor modulator (SERM) of the triphenylethylene group. It is an active metabolite of tamoxifen and has been found to be effective in patients that have failed previous hormonal therapies (tamoxifen, aromat...
T18697	SNIPER(ER)-87	Others	Others
	SNIPER(ER)-87 is a chemical compound composed of a derivative of the inhibitor of apoptosis protein (IAP) ligand LCL161 conjugated to the estrogen receptor α (ERα) ligand 4-hydroxytamoxifen using a PEG linker. It effectively degrades the ERα protein with an IC50 value of 0.097 μM. Within cells, SNIPER(ER)-87 selectively recruits XIAP to ERα, and XIAP functions as the primary E3 ubiquitin ligase responsible for the degradation of ERα induced by SNIPER(ER)-87[1][2].

化合物

4-Hydroxytamoxifen

Cat.No: T4420

Synonym: ICI 79280,(Z)-4-hydroxy Tamoxifen,4-羟基他莫昔芬,trans-4-Hydroxytamoxifen

Target: Estrogen Receptor/ERR, Estrogen/progestogen Receptor

(E/Z)-4-Hydroxytamoxifen

Cat.No: T6743

Synonym: 4-羟基他莫昔芬,(E/Z)-4-羟基他莫昔芬,Afimoxifene,4-Hydroxytamoxifen

Target: Estrogen Receptor/ERR, Estrogen/progestogen Receptor

(E)-4-Hydroxytamoxifen

Cat. No.	Product Name	Target	Signaling Pathways
TN5456	Isoerysenegalensein E
	Isoerysenegalensein E shows anti-estrogenic activity comparable to that of 4-hydroxytamoxifen, a typical estrogen receptor antagonist. It shows significant cytotoxicity against HL-60 cells, it induces apoptosis in HL-60 cells through activation of the cas