Cat. No. | Product Name | Target | Signaling Pathways |
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T69966 |
Roxadustat-d5
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Roxadustat-d5 is intended for use as an internal standard for the quantification of roxadustat by GC- or LC-MS. Roxadustat is an inhibitor of hypoxia-inducible factor prolyl hydroxylase (HIF-PH; IC50s = 1.4, 1.26, and 1.32 µM for HIF-PH1, HIF-PH2, and HIF-PH3, respectively). It is selective for HIF-PH over other 2-oxoglutarate-dependent dioxygenases, including lysine-specific demethylase 5A (KDM5A), KDM5B, -5C, -5D, and -6B (IC50s = >100 µM for all). Roxadustat (10-200 µM) stabilizes HIF-1α and ... | |||
T2515 |
Roxadustat
ASP1517,FG-4592,罗沙司他 |
Ferroptosis; HIF/HIF Prolyl-Hydroxylase; HIF | Angiogenesis; Apoptosis; Chromatin/Epigenetic; Metabolism |
Roxadustat (FG-4592) 是一种口服生物可利用的缺氧诱导因子脯氨酰羟化酶抑制剂,通过增加内源性促红细胞生成素、改善铁调节和降低铁调素来促进红细胞生成,具有潜在的抗贫血活性。 |