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Search Results for " 17-phenyl trinor pgf2α "

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Cat. No.	Product Name	Target	Signaling Pathways
T30452	Bimatoprost isopropyl ester 17-phenyl trinor PGF2α-iPr,17-phenyl trinor PGF2α isopropyl ester
	Bimatoprost isopropyl ester is an F-series prostaglandin analog, which has been approved as a hypotensive drug.
T37941	17-phenyl trinor Prostaglandin F2α cyclopropyl methyl amide 17-phenyl trinor Prostaglandin F2α cyclopropyl methyl amide
	Prostaglandin F2α (PGF2α) activates the FP receptor, promoting smooth muscle contraction and luteolysis. 17-phenyl trinor PGF2α binds the FP receptor on ovine luteal cells with a relative potency of 756% compared to that of PGF2α. It is produced in vivo by the hydrolysis of 17-phenyl trinor PGF2α ethyl amide. 17-phenyl trinor PGF2α ethyl amide is used to reduce intraocular pressure related to glaucoma. 17-phenyl trinor PGF2α cyclopropyl methyl amide is a lipophilic analog of 17-phenyl trinor PGF...
T37940	17-phenyl trinor Prostaglandin F2α cyclopropyl amide 17-phenyl trinor Prostaglandin F2α cyclopropyl amide
	17-phenyl trinor Prostaglandin F2α cyclopropyl amide (17-phenyl trinor PGF2α cyclopropyl amide) is a novel analog of 17-phenyl trinor PGF2α ethyl amide. There are no published reports on the biological activity of 17-phenyl trinor PGF2α cyclopropyl amide.
T35944	15-keto-17-phenyl trinor Prostaglandin F2α ethyl amide 15-keto-17-phenyl trinor Prostaglandin F2α ethyl amide
	Bimatoprost is the Allergan trade name for 17-phenyl trinor prostaglandin F2α ethyl amide (17-phenyl trinor PGF2α ethyl amide), an F-series PG analog which has been approved for use as an ocular hypotensive drug. Oxidation of the C-15 hydroxyl group produces 15-keto-17-phenyl trinor PGF2α ethyl amide. 15-keto-17-phenyl trinor PGF2α ethyl amide is a potential metabolite of 17-phenyl trinor PGF2α ethyl amide when 17-phenyl trinor PGF2α ethyl amide is administered to intact animals. No pharmacologi...
T37946	17-trifluoromethylphenyl trinor Prostaglandin F2α 17-trifluoromethylphenyl trinor Prostaglandin F2α
	A number of 17-phenyl trinor prostaglandin F2α (17-phenyl trinor PGF2α) derivatives have been approved for the treatment of glaucoma. Of these, the unsubstituted or meta-substituted aromatic derivatives are the most potent FP receptor agonists. 17-trifluoromethylphenyl trinor PGF2α bears an aromatic ring which is reminiscent of the trifluoromethyl-phenoxy ring of travoprost ((+)-fluprostenol isopropyl ester). As an ocular hypotensive agent, it would be expected that 17-trifluoromethylphenyl trin...
T37944	17-phenyl trinor Prostaglandin F2α methyl amide 17-phenyl trinor Prostaglandin F2α methyl amide
	17-phenyl trinor Prostaglandin F2α (17-phenyl trinor PGF2α) is a metabolically stable analog of PGF2α and is a potent agonist for the FP receptor, binding with a relative potency of 756% compared to that of PGF2α. The ethyl amide of 17-phenyl trinor PGF2α bimatoprost has been approved for use as an ocular hypotensive drug. 17-phenyl trinor PGF2α methyl amide is an analog of bimatoprost. Its biological and toxicological properties have not been evaluated.
T37945	Bimatoprost methyl ester 17-phenyl trinor Prostaglandin F2α methyl ester
	Prostaglandin F2α (PGF2α) drives luteolysis and smooth muscle contraction by activating the FP receptor. Bimatoprost methyl ester is a lipophilic analog of 17-phenyl trinor PGF2α, a potent agonist for the FP receptor. 17-phenyl trinor PGF2α binds the FP receptor on ovine luteal cells with a relative potency of 756% compared to that of PGF2α. Esters of PGs serve as prodrugs, as they are efficiently hydrolyzed in certain tissues to generate the bioactive free acid.
T37930	15(R)-17-phenyl trinor Prostaglandin F2α 15(R)-17-phenyl trinor Prostaglandin F2α
	17-phenyl trinor Prostaglandin F2α N-ethyl amide (17-phenyl trinor PGF2α) is an F-series prostaglandin analog which has been approved for use as an ocular hypotensive drug, sold under the Allergan trade name 17-phenyl trinor PGF2α ethyl amide. Investigations in our lab have shown that 17-phenyl trinor PGF2α ethyl amide is converted by an amidase enzymatic activity in the human cornea to yield the corresponding free acid, with a conversion rate of about 25 μg/cornea/24 hours. The free acid, 17-ph...
T37938	17-phenoxy trinor Prostaglandin F2α ethyl amide 17-phenoxy trinor Prostaglandin F2α ethyl amide
	Prostaglandin F2α (PGF2α), acting through the FP receptor, causes smooth muscle contraction and exhibits potent luteolytic activity. Both 17-phenyl trinor PGF2α and 16-phenoxy tetranor PGF2α are metabolically stable analogs of PGF2α and potent agonists for the FP receptor. 17-phenoxy trinor PGF2α ethyl amide is a lipophilic analog of 17-phenoxy trinor PGF2α . Ethyl amides of PGs serve as prodrugs, as they are hydrolyzed in certain tissues to generate the bioactive free acid.
T37947	17-trifluoromethylphenyl trinor Prostaglandin F2α methyl ester 17-trifluoromethylphenyl trinor Prostaglandin F2α methyl ester
	Prostaglandin F2α (PGF2α), acting through the FP receptor, causes smooth muscle contraction and exhibits potent luteolytic activity. 17-trifluoromethylphenyl trinor PGF2α is an analog of PGF2α that shares the meta-trifluoromethyl group of travoprost with the 17-phenyl trinor modification of latanoprost. It is anticipated to be a potent and selective agonist of the FP receptor, with potential applications in glaucoma and luteolysis. 17-trifluoromethylphenyl trinor PGF2α methyl ester is a lipophil...
T36908	Bimatoprost grenod 15-(6-nitroxyhexanoyl)-17-phenyl trinor Prostaglandin F2α
	Bimatoprost grenod(15-(6-nitroxyhexanoyl)-17-phenyl trinor PGF2α) is a nitric oxide-donating derivative of 17-phenyl trinor PGF2α.1It increases cGMP levels in rabbit aqueous humor and iris ciliary body when topically administered at a concentration of 0.042%. Topical administration of 15-(6-nitroxylhexanoyl)-17-phenyl trinor PGF2α(0.14%) reduces intraocular hypertension (IOP) in a rabbit model of hypertonic saline-induced transient ocular pressure. It also reduces IOP in a cynomolgus monkey mode...
T37943	17-phenyl trinor Prostaglandin F2α isopropyl ester 17-phenyl trinor Prostaglandin F2α isopropyl ester
	17-phenyl trinor PGF2α N-ethyl amide is an F-series prostaglandin analog which has been approved for use as an ocular hypotensive drug, sold under the Allergan trade name Bimatoprost. The N-ethyl amide prostaglandin prodrugs are converted to the active free acid more slowly than the analogous prostaglandin ester prodrugs such as latanoprost. This product is the isopropyl ester of the free acid prostaglandin which corresponds to Bimatoprost. The free acid, 17-phenyl trinor PGF2α, is a potent FP r...
T37777	17-trifluoromethylphenyl trinor Prostaglandin F2α ethyl amide 17-trifluoromethylphenyl trinor Prostaglandin F2α ethyl amide
	Prostaglandin F2α (PGF2α), acting through the FP receptor, causes smooth muscle contraction and exhibits potent luteolytic activity. 17-trifluoromethylphenyl trinor Prostaglandin F2α (17-trifluoromethylphenyl trinor PGF2α) is an analog of PGF2α that shares the meta-trifluoromethyl group of travoprost with the 17-phenyl trinor modification of latanoprost. It is anticipated to be a potent and selective agonist of the FP receptor, with potential applications in glaucoma and luteolysis. 17-trifluoro...
T37948	17-trifluoromethylphenyl-13,14-dihydro trinor Prostaglandin F2α 17-trifluoromethylphenyl-13,14-dihydro trinor Prostaglandin F2α
	A number of 17-phenyl trinor prostaglandin F2α(17-phenyl trinor PGF2α) derivatives have been approved for the treatment of glaucoma.1,2,3Of these, the ones wherein the 13,14-double bond has been hydrogenated retain relatively good potency, but show a significantly reduced incidence of local irritant side effects.417-trifluoromethylphenyl-13,14-dihydro trinor PGF2αbears an aromatic ring which is reminiscent of the trifluoromethyl-phenoxy ring of travoprost ((+)-fluprostenol isopropyl ester). As a...
T37934	15-keto-17-phenyl trinor Prostaglandin F2α 15-keto-17-phenyl trinor Prostaglandin F2α
	Bimatoprost is an F-series prostaglandin (PG) analog which has been approved for use as an ocular hypotensive drug. Oxidation of the C-15 hydroxyl group and amide hydrolysis of Bimatoprost produces 15-keto-17-phenyl trinor PGF2α. 15-keto-17-phenyl trinor PGF2α is a potential metabolite of bimatoprost when administered to animals. 15-keto PG analogs are potential minor impurities in commercial preparations of their corresponding bulk drug compounds. Although much less potent that the parent compo...
T37939	N-Desethyl Bimatoprost 17-phenyl trinor Prostaglandin F2α amide
	N-Desethyl Bimatoprost (17-phenyl trinor PGF2α amide) is an F-series PG analog in which the C-1 carboxyl group has been modified to an unsubstituted amide. PG esters have been shown to have ocular hypotensive activity. PG N-ethyl amides were recently introduced as alternative PG hypotensive prodrugs. Although it has been claimed that PG amides are not converted to the free acids in vivo, studies have shown that bovine and human corneal tissue converts the amides of various PGs to the free acids ...

化合物

Bimatoprost isopropyl ester

Cat.No: T30452

Synonym: 17-phenyl trinor PGF2α-iPr,17-phenyl trinor PGF2α isopropyl ester

17-phenyl trinor Prostaglandin F2α cyclopropyl methyl amide

Cat.No: T37941

Synonym: 17-phenyl trinor Prostaglandin F2α cyclopropyl methyl amide

17-phenyl trinor Prostaglandin F2α cyclopropyl amide

Cat.No: T37940

Synonym: 17-phenyl trinor Prostaglandin F2α cyclopropyl amide

15-keto-17-phenyl trinor Prostaglandin F2α ethyl amide

Cat.No: T35944

Synonym: 15-keto-17-phenyl trinor Prostaglandin F2α ethyl amide

17-trifluoromethylphenyl trinor Prostaglandin F2α

Cat.No: T37946

Synonym: 17-trifluoromethylphenyl trinor Prostaglandin F2α

17-phenyl trinor Prostaglandin F2α methyl amide

Cat.No: T37944

Synonym: 17-phenyl trinor Prostaglandin F2α methyl amide

Bimatoprost methyl ester

Cat.No: T37945

Synonym: 17-phenyl trinor Prostaglandin F2α methyl ester

15(R)-17-phenyl trinor Prostaglandin F2α

Cat.No: T37930

Synonym: 15(R)-17-phenyl trinor Prostaglandin F2α

17-phenoxy trinor Prostaglandin F2α ethyl amide

Cat.No: T37938

Synonym: 17-phenoxy trinor Prostaglandin F2α ethyl amide

17-trifluoromethylphenyl trinor Prostaglandin F2α methyl ester

Cat.No: T37947

Synonym: 17-trifluoromethylphenyl trinor Prostaglandin F2α methyl ester

Bimatoprost grenod

Cat.No: T36908

Synonym: 15-(6-nitroxyhexanoyl)-17-phenyl trinor Prostaglandin F2α

17-phenyl trinor Prostaglandin F2α isopropyl ester

Cat.No: T37943

Synonym: 17-phenyl trinor Prostaglandin F2α isopropyl ester

17-trifluoromethylphenyl trinor Prostaglandin F2α ethyl amide

Cat.No: T37777

Synonym: 17-trifluoromethylphenyl trinor Prostaglandin F2α ethyl amide

17-trifluoromethylphenyl-13,14-dihydro trinor Prostaglandin F2α

Cat.No: T37948

Synonym: 17-trifluoromethylphenyl-13,14-dihydro trinor Prostaglandin F2α

15-keto-17-phenyl trinor Prostaglandin F2α

Cat.No: T37934

Synonym: 15-keto-17-phenyl trinor Prostaglandin F2α

N-Desethyl Bimatoprost

Cat.No: T37939

Synonym: 17-phenyl trinor Prostaglandin F2α amide

Cat. No.	Product Name	Target	Signaling Pathways
T20939	Bimatoprost acid 17-phenyl trinor PGF2α,17-phenyl trinor Prostaglandin F2α	GPR	Endocrinology/Hormones; GPCR/G Protein
	Bimatoprost acid (17-phenyl trinor PGF2α) 是一种代谢稳定的 PGF2α 类似物，对 FP 受体具有潜在的拮抗活性。与 PGF2α 相比，它与绵羊黄体细胞上的 FP 受体结合的相对效力为 756%。

天然产物

Bimatoprost acid

Cat.No: T20939

Synonym: 17-phenyl trinor PGF2α,17-phenyl trinor Prostaglandin F2α

Target: GPR

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