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抑制剂 & 化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T62792	14α-Demethylase/DNA Gyrase-IN-1
	14α-Demethylase/DNA Gyrase-IN-1 (Compound 7c) 是一种 14α-Demethylase/DNA Gyrase 的有效抑制剂，具有抗菌作用。
T62389	14α-Demethylase/DNA Gyrase-IN-2
	14α-Demethylase/DNA Gyrase-IN-2 (Compound 6a) 是一种 14α-Demethylase/DNA Gyrase 的有效抑制剂，具有抗菌作用。
T12376	PC945 Opelconazole	Others	Others
	PC945 (Opelconazole) 是一种有效的广谱抗真菌化合物，对烟曲霉甾醇 14α-去甲基酶 (CYP51A/CYP51B) 有抑制作用，可用于研究肺部真菌感染。
T68575	Pyrisoxazole
	Pyrisoxazole is a novel fungicide inhibitor of Sterol 14α-demethylase.
T64029	Antifungal agent 42
	Antifungal agent 42 是一种抗真菌剂，对生物膜形成具有抑制作用。Antifungal agent 42 能够抑制 C.alb.的 lanosterol 14α-demethylase (CYP51)。
T63285	Antifungal agent 40
	Antifungal agent 40 是抗真菌剂，能够延伸到 C.alb.CYP51 的狭窄疏水口袋 II 中，可抑制 lanosterol 14α-demethylase (CYP51) 的活性，对生物膜的形成具有抑制作用。
T70661	Azalanstat mesylate
	Azalanstat mesylate is an anti-obesity drug acting as a lanosterol 14α-demethylase inhibitor. Azalanstat mesylate has been shown to inhibit cholesterol synthesis in HepG2 cells, human fibroblasts, hamster hepatocytes and hamster liver, by inhibiting the cytochrome P450 enzyme lanosterol 14 alpha-demethylase. When administered orally to hamsters fed regular chow, RS-21607 (50 mg/kg/day) lowered serum cholesterol in a dose-dependent manner (ED50 = 62 mg/kg) in a period of 1 week. It preferentially...
T70660	Azalanstat HCl
	Azalanstat HCl is an anti-obesity drug acting as a lanosterol 14α-demethylase inhibitor. Azalanstat HCl has been shown to inhibit cholesterol synthesis in HepG2 cells, human fibroblasts, hamster hepatocytes and hamster liver, by inhibiting the cytochrome P450 enzyme lanosterol 14 alpha-demethylase. When administered orally to hamsters fed regular chow, RS-21607 (50 mg/kg/day) lowered serum cholesterol in a dose-dependent manner (ED50 = 62 mg/kg) in a period of 1 week. It preferentially lowered l...
T79550	Antifungal agent 68
	Antifungalagent 68（compound 10）是抗真菌剂，针对念珠菌和格特隐球菌。它通过抑制麦角甾醇的生物合成发挥作用，靶向羊毛甾醇 14α-去甲基酶（CYP51）。Antifungalagent 68的咪唑环能与CYP51的血红素基团发生相互作用。
T71142	Tebuconazole-d9
	Tebuconazole-d9 is intended for use as an internal standard for the quantification of tebuconazole by GC- or LC-MS. Tebuconazole is a triazole fungicide that is active against both seed and foliar fungi. It inhibits 14α-demethylase isolated from U. maydis and S. bicolor with IC50 values of 0.05 and 0.16 nM, respectively. It inhibits the androgenic effect of the androgen receptor agonist DHT (IC20 = 2.89 µM) and is cytotoxic (EC20 = 38.9 µM) in an MDA-kb2 assay. Tebuconazole (50 and 100 mg/kg per...

化合物

14α-Demethylase/DNA Gyrase-IN-1

Cat.No: T62792

Synonym:

Target:

14α-Demethylase/DNA Gyrase-IN-2

Synonym: Opelconazole

Cat. No.	Product Name	Target	Signaling Pathways
T1011	Itraconazole 伊曲康唑,R51211	P450; Hedgehog/Smoothened; Antibiotic; Autophagy; Antifungal	Autophagy; GPCR/G Protein; Metabolism; Microbiology/Virology; Stem Cells
	Itraconazole (R51211) 是三唑类抗真菌药，也是口服活性的Hedgehog 信号通路拮抗剂，IC50约为 800 nM。它也是 oxysterol-binding protein 抑制剂。它抑制羊毛甾醇 14α-脱甲基酶，从而抑制羊毛甾醇向麦角固醇的氧化转化。它有抗癌和抗血管作用。

天然产物

Itraconazole

Cat.No: T1011

Synonym: 伊曲康唑,R51211

Target: P450, Hedgehog/Smoothened, Antibiotic, Autophagy, Antifungal

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