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Interferon alpha 1/IFNA1 Protein, Mouse, Recombinant (His)

产品编号 TMPY-04634

别名: Ifa1, Interferon α1, interferon, α1, 干扰素, interferon, alpha 1

Interferon alpha 1/IFNA1 Protein, Mouse, Recombinant (His) is expressed in yeast with His tag. The predicted molecular weight is 20.5 kDa and the accession number is A0A7R8GV68.

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Interferon alpha 1/IFNA1 Protein, Mouse, Recombinant (His)

规格	价格/CNY		货期	数量
100 μg	￥ 3,930		5日内发货
1 mg	￥ 29,000		5日内发货

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参考文献

生物活性	Measured in antiviral assays using L929 cells infected with vesicular stomatitisvirus (VSV). The ED50 for this effect is 20-100 pg/mL.
产品描述	Interferon alpha 1/IFNA1 Protein, Mouse, Recombinant (His) is expressed in yeast with His tag. The predicted molecular weight is 20.5 kDa and the accession number is A0A7R8GV68.

种属	Mouse
表达系统	P. pastoris (Yeast)
标签	C-His
蛋白编号	A0A7R8GV68
别名	Ifa1, Interferon α1, interferon, α1, 干扰素, interferon, alpha 1
蛋白构建	The Mouse Ifna1 (NP_034632.2) (Cys24-Lys189) was expressed with a polyhistidine tag at the C-terminus.
蛋白纯度	> 90 % as determined by SDS-PAGE.
分子量	20.5 kDa (predicted)

内毒素	Please contact us for more information.
缓冲液	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
复溶方法	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted proteinsolutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式	In general, Lyophilized powders are shipping with blue ice.
研究背景	IFNA1, also known as IFN-alpha and IFNA, belongs to the alpha/beta interferon family. Interferons(IFNs) are proteins made and released by host cells in response to the presence of pathogens such as viruses, bacteria, parasites, or tumor cells. They belong to the large class of glycoproteins known as cytokines. IFNs stimulate the production of two enzymes: a protein kinase and an oligoadenylate synthetase. They allow for communication between cells to trigger the protective defenses of the immune system that eradicate pathogens or tumors. IFNs can activate immune cells, such as natural killer cells and macrophages; they increase recognition of infection or tumor cells by up-regulating antigen presentation to T lymphocytes, and they also increase the ability of uninfected host cells to resist new infection by the virus. Leukocyte interferon is produced predominantly by B lymphocytes. Immune interferon is produced by mitogen- or antigen-stimulated T lymphocytes. IFNA1 is produced by macrophages and has antiviral activities.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy

参考文献

1. Takayama I,et al. (2012) The nucleocapsid protein of measles virus blocks host interferon response. Virology. 424(1):45-55. 2. Vairo D,et al. (2011) Severe impairment of IFN-? and IFN-? responses in cells of a patient with a novel STAT1 splicing mutation. Blood. 118(7):1806-17. 3. Bhattacharya S,et al. (2011) Bcr-abl signals to desensitize chronic myeloid leukemia cells to IFN? via accelerating the degradation of its receptor. Blood. 118(15):4179-87.

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Keywords

Interferon alpha 1/IFNA1 Protein, Mouse, Recombinant (His) Ifa1 interferon, a 1 Interferon α1 interferon, α1 干扰素 interferon, α 1 interferon, alpha 1 recombinant recombinant-proteins proteins protein

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